Recurrent miscarriages tests and treatments thread

Some of us have talked about having a thread about tests / treatment for recurrent miscarriage. Here is some info that I have found while in dilemmas about this!

The Royal College of Obstetricians and Gynaecologists has guidelines on this [[http://www.rcog.org.uk/womens-health...green-top-25]]

A helpful book is "Miscarriage: what every woman needs to know" by Lesley Regan, which is quite scientific and all about the various tests. Also "Miscarriage, Medicine and Miracles" by Bruce Young (American dr).

Some NHS clinics seem to test hormones, mine doesn't routinely do this.

There are also some, controversial blood tests for "natural killer cells":
[[http://www.hfea.gov.uk/59.html]], which you can only get privately.

In Liverpool there is a trial about natural killer cells where they are doing biopsies of the womb: there is information on the Miscarriage Association website.

Sorry, just realised that attached totally the wrong Royal College guideline, it's all about service provision in early pregnancy units! I meant to attach this one http://www.rcog.org.uk/womens-health...line-means-you

Hi Smiler13,

Great thread, we should keep this going with our tests and results so here's mine for starter.

2nd MC - all blood viles done including hubby's - results were all clear whilst waiting on my results I mc again with a BO. Gyne put it down to bad luck

Changed gyne and have had further testing, however in the meantime he's put me on 75mg aspirin and Clexane daily injections (both thin the blood):

Infection screen - BV, chlamydia etc - All clear
Progesterone - which is low
NKC - awaiting appointment

The NKC study says getting the biopsy from the womb is accurate rather than having bloods done to test this, my new gyne agrees.

Thanks for thread Smiler.

As per your 1st thread you state that natural killer cells is a private test but I got tested for this under NHS at St Georges. Please see below all the tests I've had so far.... I got so much blood taken!

BLOOD TESTS

* Chromosome studies - this is based on a blood test, and both partners are tested.

* Specific immunological testing (conducted as part of our on-going research programme): Natural killer cells - numbers and activation Cytokines - especially MIC-1and Th1 and Th2 cytokines

* Auto-immune screen - includes anti-nuclear antibodies, and anti-dsDNA antibodies

* Primary antiphospholipid syndrome (so-called "sticky blood syndrome") screen - including anticardiolipin antibody and lupus anticoagulant.

* Full thrombophilia screen (including Factor V Leiden mutation)

* Day 3-4 blood test for a hormonal profile to include luteinising hormone (LH), follicle stimulating hormone (FSH), prolactin, testosterone and sex hormone binding globulin (SHBG), and thyroid function.

* A biochemical profile to include a blood sugar, kidney and liver function.

SCANS

* Pelvic ultrasound scan - usually transvaginal

SWABS

* Infection screen - a vaginal swab for bacterial vaginosis, and cervical swab for Chlamydia


I think I had thorough testing but maybe I am wrong so would love to know what everyone else has had tested.

Brilliant thread, thank you ladies Apologies for cutting and pasting from the previous post .

Tests for me so far (not referred to date, will not be referred until OH has his sperm sample taken on 25 November):

Bloods

Primary antiphospholipid syndrome (so-called "sticky blood syndrome") screen - including anticardiolipin antibody and lupus anticoagulant.

Full thrombophilia screen (including Factor V Leiden mutation)

Day 5/21 blood tests including luteinising hormone (LH), follicle stimulating hormone (FSH), prolactin and thyroid function.

Diabetes, chlaymdia, rubella

All have come back normal/no action

Rumps x

Hi Ladies. I have recurrent miscarriages after my daughter who is 7.
I've had chromosome test, auto-immune, aps, and thrombophilia, but everything came back normal. They don't no why, I had a uneventful normal pregnancy with my daughter but then go on to have recurrent miscarriages all between weeks 6-8. I have tried baby aspirin and prometrium (progesterone)/combination of both with no results. Doc think my body reacts to pregnancy and then starts forming clots in the placenta.

I'm currently 6 wks 2 and I'm taking 81 mg aspirin (anticoagulant),
200mg prometrium (to make it stick) and 40 mg Lovenox (blood thinner). So hopefully this combination works. First u/s on the monday 17th Aug...will update then.

MS started kicking in early this week with m/c didn't have MS so hopefully this is a good sign. Good Luck to you girls!

I had tests done.. i had the straight forwards ones that they do in all hospitals. Got the answers within 3 months. was the worst possible outcome

Currently waiting on results but have been tested for following:

Karotyping - me & oh
Hormone profile - FSH, LH estrogen, progesterone, endocrines
Thyroid
Immunology
Antiphospholipid (inc lupus)
Blood sugar, kidney, liver function

Plus after 3 D&C's fetus and tissue have been tested and all have been clear.


Just another question I have had hormone day 21 etc.... done by my GP after my 2nd mc and they were fine - however, am thinking as the above testing was done the same day I had my last D&C at the hosp surely my hormones would have been up the left on that day and hence those particular results may not be accurate?? Do you think I should go and get these done with my GP again before October (if my AF eventually comes back!!)?

3 m/c also unexplained infertility
tests:

HSG - clear
Lap - removed scarring from previous surgery
Hysterscopy - clear
D&C (sent to path) - clear
Progesterone - low, prescibed Prometrium and Clomid
Hydrotubation - clear
blood work - good
husband's seamen analysis - results not received yet
several ultrasound scans - clear, one cyst
tests for STI's - negative

great thread....I've had alot of blood work done, checked for STD's - all negative. Waiting OH blood results. No idea what they tested my blood for, my gyne appointments are straight in - straight out, have no time for questions
Never had a scan or anything further but hopefully after my refferal I will get more tests and hopefully some anwers xx