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Old Mar 8th, 2010, 16:48 PM   1
Dannie138
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HCG Levels...


I called today...and all I could get out of the woman is that:

1) My levels were 9500 at my confirmation appt (baby measuring 6 weeks, 4 days on 2/3)
2) Medical miscarriage started 2/24 after baby confirmed w/o heartbeat on 2/23 (measuring 7 week range). As of 3/1, my HCG was 5350.

That sounds rather high to me still...but the major bleeding occured on 3/2, so maybe a drop will show on today's bloodwork (I get the results tomorrow).

I'm feeling anxious. Is this normal? I feel like the drop should have been more?



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Old Mar 8th, 2010, 17:15 PM   2
Carmello_01
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I'm so,so,so sorry you are going through this. With my losses I didn't have any hCG 'numbers' to refer to - I began bleeding before I knew anything was wrong.

From what I know about hCG though, that from the moment the hCG 'enters' your system it has a half-life of 36 hours. Although your levels were 9500 on confirmation of your pregnancy (6+4), your levels may have been higher when you found out your little one grew wings ( measurement 7+ weeks, but expected gestational age at the scan 21 days later of 9+4) so unfortumatley you are comparing numbers from an unknown quantity.
And even though bubs measured 7 weeks it doesn't nessessarily mean that bubs passed on at around 7 weeks. At that young age the bub's remains can shrink very rapidly over a course of even just a few days -possibly giving an inaccurate age measurement. (I'm so sorry, I don't know how to convey this accurately without sounding cold and clinical...but rest assured I know this from my own experience )

What is most important is that your levels are dropping, and they will continue to drop given the major bleed has begun. Again, I am so,so sorry.



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Old Mar 8th, 2010, 18:27 PM   3
Dannie138
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Quote:
Originally Posted by Carmello_01 View Post
I'm so,so,so sorry you are going through this. With my losses I didn't have any hCG 'numbers' to refer to - I began bleeding before I knew anything was wrong.

From what I know about hCG though, that from the moment the hCG 'enters' your system it has a half-life of 36 hours. Although your levels were 9500 on confirmation of your pregnancy (6+4), your levels may have been higher when you found out your little one grew wings ( measurement 7+ weeks, but expected gestational age at the scan 21 days later of 9+4) so unfortumatley you are comparing numbers from an unknown quantity.
And even though bubs measured 7 weeks it doesn't nessessarily mean that bubs passed on at around 7 weeks. At that young age the bub's remains can shrink very rapidly over a course of even just a few days -possibly giving an inaccurate age measurement. (I'm so sorry, I don't know how to convey this accurately without sounding cold and clinical...but rest assured I know this from my own experience )

What is most important is that your levels are dropping, and they will continue to drop given the major bleed has begun. Again, I am so,so sorry.

I appreciate the answer. I'm happy it's going down, but I didn't expect it to be so high still. I can't wait until tomorrow to see what today's number is...and if the crazy bleeding last Tuesday made a "positive" impact.

Is there some sort of estimate to how fast it leaves the system during a miscarriage or is it completely random?



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Old Mar 8th, 2010, 23:34 PM   4
Carmello_01
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hCG breaks down and then leaves our system through any way that water leaves our body - weeing being the most obvious (hence pee-on-a-stick tests) but of course sweating,the moisture in our breath etc.

So with the half-life of hCG being 36 hours is an average, as everyone's body is different it's hard to say exactly when you could expect to have a 'non-pregnant' hCG level :<5.0 mIU/ml (or interestingly but off topic- postmenopausal: <9.5 mIU/ml.)

Its also impossible to predict really when your hCG numbers will definitley reach non-pregnant levels, but I guess you could estimate that if the amount of hCG in your system halves every 36 hours -
on 1st of March your level was 5350,
36 hours or a day and a half later you could expect you level to be 2675,
36 hours after that (4th March) 1337.5,
36 hours after that 688.75,
+36hrs (7th March) 334.38,
+36hrs 168.19,
+36hrs (10th march) 83.59,
+36hrs 41.8,
+36hrs (13th March) 20.9,
+36hrs 10.45,
+36hrs (16th March) 5.25.

So by the 19th of March you could safely expect that all the hCG would be out of your system, at least to a non-pregnant level.
Half life is an interesting thing, where it would be normal to expect 'a half life of 36 hours' to mean
eg. 1st March 2000 mIU/mL,
+36hrs 1000,
+ 36hrs or 4th March 0.0
-therefore all hCG calculated out of the system in 3 days, but this is not the case as it really is a more of a rapid-then-slow decline:
eg.
1st march 2000 mIU/mL,
+36hrs 1000,
+36hours or 4th March 500,
+36 hours 250,
+36 hours or 7th March 125
+36 hours 62.5
+36 hours or 10th March 31.25
+36 hours 15.62
+36 hours or 13th March 7.81
+36 hours 3.9

Hopefully this helps, sorry it's long winded but it's a little complicated. It all looks so neat and calculated there, but it is really an estimate. I guess you could say it would be accurate within a few days either way for most women.

Having a big bleed is a really good,healthy (although devastating) indication that your body is 're-setting' itself, ready to start ovulating again and building up a healthy uterus lining home for bubs to implant if and when you are ready to try again. As for calculating when you'll start ov'ing again, well that one's for mother nature!

In the mean time it's so important to grieve for as long as you need, and to never,ever feel weird or silly for doing so. Rest,eat well and take care of you!



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Old Mar 9th, 2010, 05:20 AM   5
Dannie138
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Thank you for such a great answer. I had it figured out similar to yours, but thought it had a half-life of 48 hours approximately (Not sure where I read that). Your answer makes it quicker. lol...

I get my test results for yesterday (8th) this morning. I'll come back and post it so we can see how it fits in...

On a curious note, if I'm not drinking enough, would the HCG take longer to leave or is it just more concentrated? (I always have gotten in trouble with my OB- not a water fan and drink nowhere near what I should...lol)



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Old Mar 9th, 2010, 14:46 PM   6
QueenieMurphy
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Hi Dannie

Just wanted to say dont worry - day before my ERPC my HCG was 45500!!! And my mmc had occurred two weeks before - my body kept producing for some reason.

25 days later it was 14 and then I got my first AF at 32 days. So don't worry, some people go straight back to under 5 really quick some take little bit longer but its all normal.

xx



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Old Mar 9th, 2010, 14:48 PM   7
Dannie138
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Fantastic news....

As of yesterday, it is now 138.4! (What a drop...) They said next week might be my last blood work...



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Old Mar 9th, 2010, 15:44 PM   8
Carmello_01
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Great news about your hCG level



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Old Mar 9th, 2010, 15:53 PM   9
Dannie138
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Quote:
Originally Posted by Carmello_01 View Post
Great news about your hCG level
Thanks-- I'm relieved that it seems to be getting to the end. I just want to be healthy and try again as soon as it's possible (and safe ) Now when I see that negative preg test, I really will be thrilled!

So should I expect AF approximately a month from when it hits 0 or could it be sooner? I really crampy today, so I'm curious if the "rebuilding" process is already starting.



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Old Mar 10th, 2010, 05:40 AM   10
QueenieMurphy
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I got my AF a week after I hit 14. I don't think I ovulated before my first AF.



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