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Old Aug 12th, 2011, 15:03 PM   1
ThirdxLucky
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NK Cells?


Now I am officially a 'recurrent miscarriage' patient I have been researching reasons (all tests so far have come back normal).

Has anybody looked into Natural Killer cells and suppressing the immune system to allow babe to establish and get strong enough to fight back?

It is a new thing and not all docs recognise it so I was wondering if anyone had the name of a good fertility specialist I could talk to about it?

I just need to find some answers and can't imagine trying again until I have a reason to believe something has changed and it will have a chance.



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Old Aug 12th, 2011, 17:46 PM   2
lauraemily17
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I've just been referred to a recurrent miscarriage clinic, was very surprised as didn't know my local hospital had 1 and even more surprised they'd see me after 2 miscarriages, generally in England you have to have 3!!

I too did lots of research after my second mc & am sure I have an auto-immune problem, perhaps caused by elivated natural killer cells. I already have 2 other health probs caused by auto-immune probs so it makes sense for it also to affect my fertility.

I thought I'd struggle to get immunology tests but they've actually done it straight away, unfortunately I have to wait 8 weeks for the results so now on a break TTC.

Do you live in England? I can't advise on a hood fertility specialist buy I would strongly advise you demanding a referral by you GP & demanding immunology tests. In my eyes, more than 1 mc is not bad luck, there must be more to it. I highly recommend reading the book - is your body baby friendly by Dr Alsn Beer. It will tell you all you need to know.

I hope you find yourself a good Dr & find a solution so your next BFP will bring you your rainbow baby. xx



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Old Aug 13th, 2011, 09:45 AM   3
Mon_n_john
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I just recently got diagnosed with high natural killer cells too. It sounds like you need an immunilogical blood test to confirm. I'm not in the UK so I can't suggest anyone over there to do the testing but if you are in the US let me know and I'll give you some clinic names.

FYI, there is a good chance you'll have to pay for the test out of pocket. It cost me $766US but it was worthe very penny. I would have never known otherwise.



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Old Aug 15th, 2011, 12:43 PM   4
Mon_n_john
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Just a quick update ladies: I had my appt. today with my RE regarding the high natural killer cells. She said that in her office they only do two types of treatment for it: IVIG (intravenous immunoglobulin) or intralipids. IVIG is $3,000 or so per infussion while intralipids are about $750 per infussion. She said that her office has seen very similar results with both treatments.

Given the high cost of the IVIG we are opting for the intralipids to start with. The plan is for me to have 1 treatment before getting pregnant. My first treatment will be this Friday when I will be CD 7. Then I will come in at around 10 DPO for an early beta test. If I am pregnant I will get another infussion right away. She expects me to need around 4-5 infussions up to my 12th week of pregnancy. She will then test the NK cells again and if they are still high I will get more infussions as needed. She said I would not need them past 26 weeks along.

None of this is covered by insurance and everytime I need one I will need to shell out $750 but that's OK. She said I don't have to wait to TTC and that we can try again this cycle! I'm so excited. She said we should give this 3-4 cycles and see how it goes. If for some reason I do get pregnant and have another mc on the intralipids I would need to do the IVIG but she doubts that will be the case.

So, my first treatment is this Friday at 10:30 a.m. I will be there about 2.5 hours with an IV in my arm. I hate needles, how can I be this excited about getting the treatment? I should be able to get my first beta test done about 3 weeks from today. Can't wait, I'm excited that this may be the answer to my prayers!



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Old Aug 15th, 2011, 12:48 PM   5
Twinkie210
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I am so glad you are finally getting some answers, good luck with your treatments. I'll keep my fingers crossed for a BFP!



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Old Aug 15th, 2011, 12:51 PM   6
BFPSeeker
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Hi

I have had 3 early miscarriages and my NHS tests have also all come back normal. My GP and the NHS recurrent miscarriage clinic are saying there is nothing more they can test so I have made a private appointment with Dr Shehata in London at The Miscarriage Clinic. I have appointment in 3 weeks. He specialises in immunological testing so hopefully he will find something. First appointment is 300 and I expect treatment will be quite expensive but for me it will be worth every penny if it gets me a baby!



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Old Aug 15th, 2011, 12:54 PM   7
Mon_n_john
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I feel the same way BFP seeker, good luck to you! And thanks a bunch for the warm wishes Twinkie!



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Old Aug 15th, 2011, 13:37 PM   8
Chilli
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I was lucky enough to have a consultant that would give anything a bash as I fell pg for 4th time, and so was on prednislone steroids for first 12 weeks without having any testing. I am now 32 weeks!!! I have no evidence that this is what made the difference and I have chnged sveral other things too, but having researched that it seemed the only likely side effect would be an increased risk of cleft pallete I thought it worth that risk! You could always ask forcefully liike I did and save yourself all the stress and expense of further testing. Good luck



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Old Aug 15th, 2011, 17:25 PM   9
ThirdxLucky
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Quote:
Originally Posted by Mon_n_john View Post
Just a quick update ladies: I had my appt. today with my RE regarding the high natural killer cells. She said that in her office they only do two types of treatment for it: IVIG (intravenous immunoglobulin) or intralipids. IVIG is $3,000 or so per infussion while intralipids are about $750 per infussion. She said that her office has seen very similar results with both treatments.

Given the high cost of the IVIG we are opting for the intralipids to start with. The plan is for me to have 1 treatment before getting pregnant. My first treatment will be this Friday when I will be CD 7. Then I will come in at around 10 DPO for an early beta test. If I am pregnant I will get another infussion right away. She expects me to need around 4-5 infussions up to my 12th week of pregnancy. She will then test the NK cells again and if they are still high I will get more infussions as needed. She said I would not need them past 26 weeks along.

None of this is covered by insurance and everytime I need one I will need to shell out $750 but that's OK. She said I don't have to wait to TTC and that we can try again this cycle! I'm so excited. She said we should give this 3-4 cycles and see how it goes. If for some reason I do get pregnant and have another mc on the intralipids I would need to do the IVIG but she doubts that will be the case.

So, my first treatment is this Friday at 10:30 a.m. I will be there about 2.5 hours with an IV in my arm. I hate needles, how can I be this excited about getting the treatment? I should be able to get my first beta test done about 3 weeks from today. Can't wait, I'm excited that this may be the answer to my prayers!
Thanks for this info - I so hope this is the answer for you! I will be following your story - will you keep us updated here or do you have a journal elsewhere on the site?

I really want my NK cells levels tested but I'm in the UK and I don't think they do that as standard - I might try the London clinic mentioned.

Good luck everyone xx



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Old Aug 15th, 2011, 17:29 PM   10
ThirdxLucky
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Quote:
Originally Posted by BFPSeeker View Post
Hi

I have had 3 early miscarriages and my NHS tests have also all come back normal. My GP and the NHS recurrent miscarriage clinic are saying there is nothing more they can test so I have made a private appointment with Dr Shehata in London at The Miscarriage Clinic. I have appointment in 3 weeks. He specialises in immunological testing so hopefully he will find something. First appointment is 300 and I expect treatment will be quite expensive but for me it will be worth every penny if it gets me a baby!
Hey BFP seeker - how dis you find the London clinic? Were you referred from your docs or did you research them and contact them directly? Also, did you gave to wait long to get in? Sorry - so many questions!!

You're right - the money becomes unimportant after three losses. Let's hope we get our rainbow babies next time xx



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