Hi girls,

I have hypermesis gravidarum and am on zofran for it. I am 8 weeks along and it seems to be getting worse when my meds wear off. Also some people have said zofran stopped working for them which scares me, because without the zofran working I'd be in the hospital. Has anyone dealt with hypermesis? What did you go through? When did it ease up?

Hey sweetie.

Sorry to hear you have HG I hate hearing people have it because when you've been there you know how hard it is and wish for better for others

I started out on Cyclizine and then moved on to Metoclopramide before switching to Ondansetron (Zofran) at 16 weeks.

I am now on a mix of Metoclopramide and Ondansetron (Zofran) which works for me - granted I've had admissions since being on this but when you're not being sick every single day you can easier deal with the bad days.

Feel free to follow my journal chick, I do all my moaning about HG in there. Hope yours goes at 14 weeks (the apparent 'average'), mine didn't

It eventually stopped working for be but I switched to the dissolvable zofran and its great! I have been hospitalized 2x for dehydration while in 1st tri. At about 15 weeks the HG eased up. Now I only take meds 1x-2x a day instead of around the clock and I CAN ACTUALLY EAT! Be prepared to gain weight slowly...Im only up 4 lbs from my pre-pregnancy weight. I gained 6 lbs over the last 4 weeks, I had just lost so much.

So sorry you are feeling yucky. Ask your dr is you can change how you take your meds and change the dosage to more often so you don't have that wear off time.

Zofran never worked for me and I was sick my entire pregnancy (sick 3 times a day was a good day all the way to birth). I had a PICC line put in at 8 weeks. Fortunatly my parents are in the medical field so it kept me out of the hospital. I was doing iv fluids daily with vitamins, plus reglan iv every 3 or 4 hrs (can't remember which) and phenergan im every 3 or 4 hrs (again can't remember which...one was at every 3 and the other every 4).

Also did b6 plus unisom....(really didn't help with as bad as I was but was worth it to me to hope to have some of the edge taken off)- google unisom in pregnancy

I hope things get better for you. Someone I know recently did a round of steroids after being in bed for 8 weeks for being so sick and is now doing great. Might be something to look up. She said she found a whole list of meds and dosages on 1 page that she took to her dr when she looked up hyperemisis gravidarum.

Good luck! Prayers for a happier pregnancy. I do say even though it is horrible, i'm ready to do it all again because that reward is so great.

Thanks for the info. I hope it goes away and doesn't last the whole time. It's so hard to get my hubby to understand how miserable I feel. He seems to think I can make myself feel better cause I have housework to do. Blah!

Hi i had HG i was hospitalised at 7weeks with it i wasnt given any meds though they knocked me back for some reason :s (and quite glad now) hope it gets better for you it is hard i have 2 kids and it was so difficult. it got a lot better at 20weeks but ive still had the odd occasion ive threw up since.

just remember its all worth it x

I have/had HG too - absolutely awful. I'm 12 weeks and was hospitalised twice at between 8 and 9 weeks for IV fluids and antiemetics. I'm home now with oral cyclizine and ondansetron. I'm hoping to start weaning myself off the ondansetron slowly - have managed to drop down from 3 in 24 hours to 1 or 2 in 24 hours as well as 2 cyclizine. This seems to be suiting me at the minute, I can actually eat and drink now and have started to regain the weight I lost early on.
I hope you start to feel a lot better very soon xx