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Old May 19th, 2013, 21:44 PM   21
dkt78
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Surprise


We had our first ultrasound last Thursday at 6w1d and found out we're expecting twins. We've been in shock and a little bit of denial all weekend. The babies measured a little small and both heartbeats were detected but they were only 111 and 113. Still, we've "graduated" and will be moving on to a regular ob/gyn. Our RE suggested we consider going to someone that deals with higher risk patients because of our history and now twins. Hopefully it's not because of the size and heartbeats. Our first appointment is June 4th. We're really looking forward to it to make sure everything is going well. In the mean time, we're trying to figure out just how this is going to work.

Boots8182, how are you doing? Have you started telling people or are you waiting?

Thanks for the well wishes Hopeful76. How's your little girl? And did you used to live in the UK? I noticed your location is now Sydney.



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Old Sep 21st, 2013, 21:07 PM   22
jenn918
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12 eggs - 0 embryos


I am 27 years old, my husband and I have been trying to conceive for nearly 3 years. We have had 7 or 8 failed iui cycles and our first heart breaking failed ivf cycle. My husband has been tested and has a great sperm count and quality. I never in a million years thought that there could be something wrong with me ... simply because I am so young and healthy, my family has always been very fertile, there is no history of having trouble conceiving, my dr never indicated that he thought there was an issue. I did lupron, gonal f, menapure, and ovidryl for this ivf cycle. I went in very confident and left just as confident. They were able to retrieve 12 eggs that looked good. I waited by the phone the following day, to hear WHEN we would transfer the embryos. I received the most shocking news that I was completely floored by, my dr was just as dumb founded. Retrieval was 9/19, when they went to check the embryos on 9/20 they found that all 12 eggs has weak shells and instead of the 1 or 2 sperm that typically penetrate the egg, all 12 of my eggs were penetrated by 100+
My dr and the ivf specialist both said they have never seen this before. The ivf specialist said that occasionally he will see 1 or 2 where this happens but never an entire batch. He said that in addition there were some other abnormalities. Basically he suggested the options going fwd are icsi but he is not confident that the results would be any different than they were this time or a donor egg.

i just am floored. I have never felt so lost and broken. I really do not know how or if i will get past this. I cannot fathom that this is it for us. I am only 27 and I just feel like I cannot accept this as the final answer. I have no completely ruled out the idea of alternate options, donor egg, adoption, etc ... but I just am not ready to through in the towel on using my own eggs.

I feel like I am going crazy, I have surfed the internet and this is the closest information I have found to my situation. I am open to ANY ANY ANY advise, suggestions, ideas, anything ...
We are meeting with our dr sometime this week to talk and I really want to be bale to have something to bring to the table.

I have felt completely lost and hopeless ... and sick however this thread has been the first glimmer of hope I have found! I could not be more happy for all the success stories posted...



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Old Sep 22nd, 2013, 08:39 AM   23
Briss
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jenn, unfortunately I do not have much experience and do not have advice, just did not want to R&R. Please do not let them bully you into donor eggs. you are young and healthy, I am sure it can be fixed one way or another. I read about other ladies having similar issues and in most cases ICSI helps. from what i gathered possible reasons can include (i) the outer layer of your eggs is faulty - ICSI is a solution; (ii) wrong protocol chosen by the clinic that weakened your eggs - change protocol/clinic. I think in your case it's probably the protocol (although I am no expert I am just thinking out loud here) because ladies with egg issues often get multiple miscarriages with this problem before going for IVF



 
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Old Sep 22nd, 2013, 14:02 PM   24
jenn918
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Thanks


Briss thank you for replying!! I appreciate any input at this point!! I have been vigorously researching and hope is slowly coming back! The ivf specialist at the clinic said that my situation was so rare that it doesn't even have a name however after spending a few hours online I am confident the situation he explained is indeed Polyspermy. I won't accept this is the final answer ... And I believe your advise is correct and much appreciated! I will not stop ... I am going exhaust all resources, I will go wherever I need to. I will go outside of the states or across the country. Someone has to know some thing!!



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Old Sep 22nd, 2013, 14:08 PM   25
Briss
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jenn, best of luck! keep us posted on your progress. I am sure other ladies will share their experience as well.



 
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Old Sep 22nd, 2013, 14:12 PM   26
jenn918
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Thank you!! I will!! Best of luck to you as well!! I am so happy someone replied..



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Old Sep 23rd, 2013, 00:50 AM   27
Hopeful76
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Hi Jenn918, just wanted to send you hugs and say that once you feel ready I would definitely say ICSI is worth a try. I'm sure you've read this thread so can see that seems to have worked for us polyspermies . My daughter is now nearly 16 months old and I can tell you I never thought we would have her when we had our polyspermy news but here we are!
Dkt78 my daughter is doing really well and yes we did move from London to Sydney - going on 2 years now since the move!



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Old Sep 23rd, 2013, 05:27 AM   28
jenn918
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Hopeful76,
First off congrats on your baby girl!!! And secondly I am ecstatic that you replied! Thank you!

If you do not mind I have a couple more questions. My dr and the embryologist said that my case we so rare, they had never seen this before, and in quote "this is so rare there is not even a name for it." I was floored. They did not give me this diagnosis of having polyspermic fertilization, this is something that I found on my own. They described my situation as followed. My stimulation was text book, they could not have been more happy with my work up and the retrieval. It was not until they went to check my eggs on 9/20 the day after retrieval did they find that 100s of sperm had penetrated the eggs, when typically only a few penetrate. He said that typically the zona pellucida (the shell) is typically really thick, he has that the shell of my eggs were abnormally thin. Is this how your dr explained your situation? There were some other abnormalities he explained but I have not found a possible answer for those yet and too I am wondering if those also stem from the polyspermy??? I have no idea just trying to figure something out

I just am trying to find anything that may be able to support what I have. I cannot accept that my situation is the first time anything like this has happened.

Would you be willing to tell me your doctor and/or embryologist name? Or if you do not want to do that can you tell me the clinic that you given this diagnose at? Did you go back to that same clinic for the ICSI? I see that you are located in Sydney previously in London, I am in The States, however my husband and I have discussed that we will go outside of The States if necessary (and obviously if we are able to afford it) but for now I would like to reach out to any doctor or clinic, present my case and see if this is something they have dealt with and maybe they can confirm my diagnosis. I have
requested my medical chart from my current care provider, so I could possibly have anything it may take to sent to another clinic.

Also, were you advised to take any supplements to make any daily changes to help improve your egg quality?
Thank you again! And I accept and appreciate that hug!! I could not be more happy for you and your child! In addition, I am thankful for the hope that this thread has given me! I will heal from this and I will give ICSI a shot but i want to make sure I am as educated as possible!



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Old Sep 23rd, 2013, 06:13 AM   29
Briss
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jenn, one of the questions that I'd have in your situation is whether there is any difference between an egg being penetrated by 2 sperm or by over 100. is it the same issue or is this two completely different scenarios? To me personally it would not make a difference, I cant see how it matters how many sperm were able to get in as long as it's more than 1, it should be treated as the same issue but I am not a specialist so I'd just ask somebody who specialises in this.



 
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Old Sep 23rd, 2013, 07:34 AM   30
jenn918
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Briss, you bring up a good point! I will absolutly look into that and bring it up in my consult!! I agree, obviously I have no medical background on this matter, however "logically" this makes sense?? I would think!



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