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Old Apr 28th, 2011, 14:22 PM   1
Hopeful76
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100% Polyspermy during IVF - anyone else had this?


Hi All, I am new to this and wish everyone well on their journeys.
Had an IVF cycle this month after 2 years TTC, 16 eggs collected, 6 fertilised but all suffered polyspermy. Has anyone else had 100% of their eggs fertilise this way? Has anyone successfully conceived (IVF or otherwise) after this happening?

We have been told what has happened is very rare and ICSI would be the option next cycle but other than that not much information.

Trying to remain hopeful but can't believe how sad I am with this news!



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Old Apr 30th, 2011, 02:07 AM   2
honey08
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no experince but just wana say goodluck



 
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Old Oct 13th, 2011, 08:39 AM   3
jkg2004
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Hello,
I am so sorry to hear the results of your ivf.... I actually just had the same thing happen, and just found out the news yesterday. I had only five eggs retrieved but all were "good". Four of them were fertilized by multiple sperm and one was fertilized but also was abnormal. I am desperately trying to learn more about this but all that I can get out of the embryologist and the dr. is that it is very rare. I want to know WHY and HOW this can happen.

Did you ever find any good explanation? If you have any resources that you want to pass on, I would be so grateful! Also, if you don't mind .... what is your situation now? Have you tried IVF again?

One thing about me ... I am suffering secondary infertility now. I have one son (whom took a long time to conceive, but is completely healthy) so I know that not all of my eggs are dysfunctional.

Any information that you have would be soo appreciated. Thanks...



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Old Oct 14th, 2011, 06:01 AM   4
Hopeful76
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There is hope


Hello,

I really feel for you and how you must be feeling. I was utterly devastated and desparate for answers. ICSI was also advised for us. We took a break for 4 months and tried again. We got 7 eggs, 6 fertilised, 4 made it to Day 3 and 3 survived to Day 5 Blastocyst. We had 1 transferred and I am now 6 wks pgnt. We still can't believe after such a devastating first cycle how far we got with the second!
Some info (we changed clinic for second cycle due to move):
first clinic: said they saw maybe 1 case of like ours a year. They said they had seen similar cases to go on with ivf (no icsi) and not have the same problem and conceive ok. They also recommended icsi.
Second clinic: they changed my stim drugs to be a constant flat dose (prev clinic had started higher and reduced during due to high oestrogen levels). Also my first clinic 'coasted' me ie they stopped my stim drugs 48hrs before trigger rather than 24. Basically we think (and the second clinic hinted) that the stim protocol didn't support my eggs well enough so they were gradually being starved so nowhere near strong enough for what was needed.
The second clinic focussed solely on keeping a constant level of stim for my eggs and said if my oestrogen went high they would deal with that by freezing embryos rather than transfer anything that cycle and risk hyperstimulation. As it turned out my oestrogen was fine second time round.
Anyway i hope this is of some use to you. Please don't lose hope. I'm sure a positive result is also possible for you. If you have any other questions don't hesitate to ask. Big hugs to you!



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Old Oct 19th, 2011, 15:29 PM   5
jkg2004
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thanks for the great news:)


this is such good news for you, congratulations!!! and thank you so much for sharing the rest of your story, and the possible explanation for the abnormal fertilization. i have spent the past week trying to find out as much as possible, but it really does seem rare. i am so happy to hear of your pregnancy - especially so relatively soon after the failed cycle. best of luck to you, and thanks again!!!

(i may pop back in with more questions if i come up with any .... i am meeting with my RE next week to give him a chance to talk to other dr.'s and do more research, since it was so rare for him as well.)



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Old Jan 10th, 2013, 21:00 PM   6
dkt78
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Hello.
I realize this post is old but I was hoping JKG2004 might share her experience since Fall 2011.
We just received news that our first IVF attempt resulted in six of eight eggs fertilizing with multiple sperm. The other two were immature and did not fertilize. Was your dr able to give you any more information? Did s/he provide any other options besides ICSI? Did you proceed with this route?
We've been trying for so long with no clear reason why we haven't been able to conceive and then to have this happen was really upsetting.
Hoping you had a positive outcome and are willing to share.
Thanks!



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Old Mar 7th, 2013, 22:35 PM   7
Boots8182
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Hi dkt78. This is my very first post - I saw your message and had to respond because my husband and I are going through the same thing. We had a failed IVF cycle in January, and I am set to begin stims on 3/15 for IVF attempt #2. With our failed cycle, we had 18 eggs retrieved. Everything went well up until that point so the news that 16 of those eggs were fertilized by more than one sperm was not only shocking but also devestating. It was my worst day since TTC in what has been a disappointing journey thus far. To put it simply - it sucked. I am so sorry you have had to experience the same pain. My team of doctors said they have known cases where ICSI has been a solution to this problem. I am anxious/scared to find out the outcome once we complete our second IVF with ICSI. Hang in there and please keep me posted.



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Old Mar 8th, 2013, 04:17 AM   8
Hopeful76
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Don't give up


I posted this question originally and I know how soul destroying this result is but please don't give up. Our second round of IVF was ICSI and we now have a beautiful, healthy 9 month old daughter keeping us on our toes! We also have 2 embryos frozen. You can see more detail of our journey in the 'there is hope' post below.
Wishing you a positive outcome



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Old Mar 18th, 2013, 23:46 PM   9
dkt78
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Thanks so much for the responses! We're now cautiously optimistic. Our dr hadn't observed this happening to all eggs before. She pretty much told us that she didn't think isci would work but if we wanted closure she was interested in what would happen if we tried. Your posts have made us feel so much better deciding to move forward with a second cycle. I'm scheduled to start stims April 5th.

Congratulations Hopeful on your little girl and best wishes to you Boots as you start your second cycle! Please let us know how it goes.

Thanks again!



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Old Mar 27th, 2013, 15:14 PM   10
Boots8182
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ICSI after Polyspermic embryos


Hello everyone,

I wanted to provide an update on the progress of our second attempt at IVF (using ICSI this time as we experienced polyspermic embryos during our first IVF attempt). My retrieval was performed yesterday (3/26) morning. After the procedure I was told they retrieved 20 eggs and that I would receive a call the next morning with an update on fertilization. After receiving many phone calls with bad news, our Doctor finally had some good news to report -- out of the 20 eggs retrieved, 17 were mature, and 15 were fertilized using ICSI. Now we play the waiting game and hope at least one of those eggs makes it to a 5 day embryo. All we need is one! If all goes well, we will transfer on Easter Sunday. This has been such an emotional journey, and we've made it one step further than where we were on our first attempt. I just pray our journey continues and the end result is our little miracle baby. More good news to come, I hope. Wishing everyone all the best as you continue on your own journey!



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