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Old Jun 3rd, 2013, 07:02 AM   1
Ibelieveitwil
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Femara success?


ladies,

I have been on clomid but I never ovulated and I was diagnosed Clomid resistant! My gynae put me on my first femara cycle and I am hoping this is it... I was just wondering if there are any success stories on femara success when clomid failed?



 
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Old Jun 4th, 2013, 09:26 AM   2
Kyla
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I saw your post and wanted to share my Femara story I have PCOS and was prescribed Clomid but only ovulated a few times without getting pregnant. I had a lap and dye to check my tubes and Ovarian Drilling done in December 2011 and then I was given Femara to try as Clomid hadn't worked for me.
I got pregnant the first month of trying with Femara (plus Metformin). Whether it was the Femara alone, Metformin and Femara or the fact I'd had ovarian drilling done which helped me respond or the whole combination, I don't know but I wanted to wish you good luck. There are lots of tales of Femara success after Clomid failure on here and I hope you get more replies.
On my Femara cycle, I had a CD21 blood test and I was so upset that my progesterone levels were really low and I thought I hadn't ovulated. I had ovulated, and I ovulated on CD19 - hence the negative CD21, and I've read Femara sometimes causes late ovulation. I took mine on CD2-6.
Also, I highly recommend using a sperm friendly lube. I used PreSeed, and I think that contributed too because although I was ovulating, I didn't get much ewcm.
My Femara baby is now 4 months old. Sending you lots of special dust



 
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Old Jun 5th, 2013, 01:44 AM   3
Ibelieveitwil
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Wow !! Thank you so much for your femara story, congrats on your baby I am also on metformin and femara but only on 2.5mg and 1500mg met, my gynae didnt want to start me off on 5mg. I have a severe hormone imbalance and only get af every 4-5 months. I really hope this is it, we have had such a rollercoaster ride with the clomid, so much disappoinment because I have never ovulated.

Can you tell me, what dose did you start on (femara and metformin)?
Was it a monitored cycle?
When did you get your bfp?
Did you get any side effects? I have extreme fatigue and night sweats (hope that means its working)

Thanks for the reply, I really hope I get more success stories, I am on day 8, finished my last dose yesterday.



 
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Old Jun 5th, 2013, 12:37 PM   4
Kyla
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Hi,

Thanks A bit more of my story

I have PCOS since my teens. I have a son who is 7, I conceived him pretty easily after losing weight which restored my periods - I was like you and only maybe getting 2/3 periods a year. DH and I started ttc after I came off the pill, and because of my PCOS I referred for a fertility specialist after 6 months of trying.
my FS prescribed Clomid and I too had the disappointment of it not working. I wasn't monitored on Clomid, just had CD21 blood tests. I did 8 Clomid cycles, going up to 100mg and I was ovulating sometimes, not others. I didn't always get a period either and I never got a true positive ic OPK. They wouldn't up the dose of Clomid from 100mg because they said it had worked but they would offer me lap and dye to check my tubes and an ovarian drilling operation. The op has an amazing success rate and I was really hopeful. I have a high BMI (37 at my worst) due to PCOS and after my operation I finally saw a FS who understood PCOS and that my weight was hormonal imbalance, not lack of control in food. I started on Metformin after the operation and built up to 1500mg. I was advised though to keep trying to lose weight as a weight loss of just 5% can trigger ovulation in women who are having annovulatory cycles. I found it so hard, I was doing Zumba, AquaFit and going to the gym 5 times a week and I barely lost a few pounds
I had CD21 blood tests on my cycles after the op and because I wasn't ovulating, my FS offered me a choice to retry Clomid or to go onto Femara. I did my research...as you may know Clomid blocks estrogen receptors in the hypothamalus whereas Femara acts on the body as an aromatase inhibitor and works in a different way and has better results in women where Clomid has failed. Femara reduces the production of estrogen temporarily causing the brain to secrete FSH and LH which stimulate follicle development. I felt I had to give Femara a go as I didn't know if Clomid was causing my lining to thin which was preventing pregnancy on the months I did ovulate.
I was given 5mg to start with which very, very loosely translates as 100mg of Clomid - the level that worked to get me ovulate. I wasn't monitored other than the blood tests. I had hardly any ewcm hence the use of PreSeed. Side effects weren't too bad, but I did have sweats and headaches. I also didn't get a true positive OPK even on the day I ovulated, it was a pale line, but a bit less pale than I had previously got in past cycles. I really thought I was out that month because of my negative CD21 so be prepared for later ovulation.
How is your BMI? Are you being monitored on your cycle and would Ovarian Drilling be an option for you?



 
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Old Jun 5th, 2013, 12:54 PM   5
Sib4Owen
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Hi ladies! This is my first Femara cycle as well! I have tried Clomid in the past (years ago before my son was born and responded overly well. I had anywhere from 10-14 eggs, but my lining was way way too thin) My doc now said he likes Femara better and I shouldn't create so many follicles and it shouldn't thin out my lining. I was diagnosed with diminished ovarian reserve and I have the MTHFR factor. I am 35 and have a son who is 4. I am dying to give him a sibling and am really hopeful this will work. My cycle is monitored...I go this Sunday for a CD10 ultrasound to count the follicles and they will tell me when I need to do the HCG shot and schedule the IUI. I also use preseed.

Ibelieveitwil where are you in your cycle?

Kyla - congrats on your baby!



 
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Old Jun 6th, 2013, 01:20 AM   6
Ibelieveitwil
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Quote:
Originally Posted by Kyla View Post
Hi,

Thanks A bit more of my story

I have PCOS since my teens. I have a son who is 7, I conceived him pretty easily after losing weight which restored my periods - I was like you and only maybe getting 2/3 periods a year. DH and I started ttc after I came off the pill, and because of my PCOS I referred for a fertility specialist after 6 months of trying.
my FS prescribed Clomid and I too had the disappointment of it not working. I wasn't monitored on Clomid, just had CD21 blood tests. I did 8 Clomid cycles, going up to 100mg and I was ovulating sometimes, not others. I didn't always get a period either and I never got a true positive ic OPK. They wouldn't up the dose of Clomid from 100mg because they said it had worked but they would offer me lap and dye to check my tubes and an ovarian drilling operation. The op has an amazing success rate and I was really hopeful. I have a high BMI (37 at my worst) due to PCOS and after my operation I finally saw a FS who understood PCOS and that my weight was hormonal imbalance, not lack of control in food. I started on Metformin after the operation and built up to 1500mg. I was advised though to keep trying to lose weight as a weight loss of just 5% can trigger ovulation in women who are having annovulatory cycles. I found it so hard, I was doing Zumba, AquaFit and going to the gym 5 times a week and I barely lost a few pounds
I had CD21 blood tests on my cycles after the op and because I wasn't ovulating, my FS offered me a choice to retry Clomid or to go onto Femara. I did my research...as you may know Clomid blocks estrogen receptors in the hypothamalus whereas Femara acts on the body as an aromatase inhibitor and works in a different way and has better results in women where Clomid has failed. Femara reduces the production of estrogen temporarily causing the brain to secrete FSH and LH which stimulate follicle development. I felt I had to give Femara a go as I didn't know if Clomid was causing my lining to thin which was preventing pregnancy on the months I did ovulate.
I was given 5mg to start with which very, very loosely translates as 100mg of Clomid - the level that worked to get me ovulate. I wasn't monitored other than the blood tests. I had hardly any ewcm hence the use of PreSeed. Side effects weren't too bad, but I did have sweats and headaches. I also didn't get a true positive OPK even on the day I ovulated, it was a pale line, but a bit less pale than I had previously got in past cycles. I really thought I was out that month because of my negative CD21 so be prepared for later ovulation.
How is your BMI? Are you being monitored on your cycle and would Ovarian Drilling be an option for you?
I have a BMI of 32 at the moment down from 35 but still high, I also have joined gym, have been going for the last 3 months and only lost about 6 pounds! Well I am having a monitored cycle so I will go in for a CD12 scan then CD16 then CD21 bloods which I am not too confident as I told my gynae I dont think I am going to respond to 2.5mg but he insisted to prevent me from being overstimulated!!! Hello!!! I havent ovulated in the last 10 months since starting treatment... anyway its my last cycle with him, we going to a FS in July as that was the earliest appointment. It seems my problem in just hormonal, everything else is fine, my uterus is good, no endo, no polyps nothing, I am just not ovulating. Never seen even a faint line on a HPT
Its such a difficult process for my DH and I, my sister got married after us, my SIL got married after us and they both expecting, my sister is giving birth in 3 weeks and it was so difficult going through this process watching her have what we cant. I just got a feeling that this month it isnt it, I mean I hope it is but its just really hard. I just wish he had started me on 5mg! Im trying to lose another 7 pounds before the FS appointment!! Your story really gives me hope, what was your BMI when you fell pregnant on femara?



 
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Old Jun 6th, 2013, 01:26 AM   7
Ibelieveitwil
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Quote:
Originally Posted by Sib4Owen View Post
Hi ladies! This is my first Femara cycle as well! I have tried Clomid in the past (years ago before my son was born and responded overly well. I had anywhere from 10-14 eggs, but my lining was way way too thin) My doc now said he likes Femara better and I shouldn't create so many follicles and it shouldn't thin out my lining. I was diagnosed with diminished ovarian reserve and I have the MTHFR factor. I am 35 and have a son who is 4. I am dying to give him a sibling and am really hopeful this will work. My cycle is monitored...I go this Sunday for a CD10 ultrasound to count the follicles and they will tell me when I need to do the HCG shot and schedule the IUI. I also use preseed.

Ibelieveitwil where are you in your cycle?

Kyla - congrats on your baby!
Hi Sib, I am currently on CD9, go for CD12 scan on monday. We are considering IUI but will discuss that with our FS. My gynae annoys me because he is just so relaxed about the whole process its over a year now since we have started trying!



 
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Old Jun 6th, 2013, 08:23 AM   8
Kyla
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Hi Sib, thank you and good luck to you too. Keep us posted on your Sunday ultrasound.

Ibelieveitwil - Isn't it frustrating when you do all you can to lose weight and just a tiny amount drops off. My FS said ladies with PCOS like me have to work 5 times as hard in the gym to get the same result as someone without hormonal imbalance.
My BMI when I conceived was 36, so higher than you're current BMI and I had a healthy pregnancy. I totally can sympathise with your situation, it's so frustrating. We were ttc for 2 years, during that time one friend got pregnant with twins and my best friend also had a baby and it took all my strength to be happy for them when I was fighting envy, self pity and despair.
2.5mg of Femara may do the trick yet I know your gynae's attitude is annoying (believe me I have been in the same position here) but I have learned that very often they are relaxed about things because they're looking at your situation from a scientific point of view and it looks positive. There seems to be no medical reason why you can't get pregnant - provided you ovulate - and Femara is a fab step in the right direction to get ovulation going.
Re weight loss, have you ever tried the South Beach diet? I find it works wonders for me to kick start weight loss, I got pregnant with my first son when I lost weight and I did it using the South Beach Diet. I think it helped a lot with my insulin levels as they'd been knocked about with the hormone imbalance.
Anyway, keep us posted and good luck




 
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Old Jun 6th, 2013, 09:37 AM   9
Sib4Owen
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Ibelieveitwil - I understand your frustration. Kyla is right, the docs are not emotionally involved so they are able to be more relaxed. Sometimes it's good because they can see things clearly, but if it goes on too long and your not comfortable with your progress, then I would get a 2nd opinion or find an RE. Good luck and let us know what your ultrasound on Monday shows. It's cool that we are at the same spot in our cycles and taking Femara. I'm looking forward to hearing about your progress

Kyla, thanks and I will keep you all posted! I love your success story, it really gives us all something to hold onto while we are going through the motions.



 
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Old Jun 7th, 2013, 01:20 AM   10
Ibelieveitwil
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ladies, thanks for the support, I am not too interested in this cycle to be honest because I have my appointment with the FS so hopefully we will get more results then, but I will still go through the motions because thats what happens when TTC. Sib, day 12 for me is on sunday but my gynae is only open monday to friday, you are so lucky to have the opportunity to have a scan then. I will be CD13 when I do my first scan.

I looked up the south beach diet, it doesnt seem to bad, going to stock my cupboards and fridge with stuff so I can start the diet asap, hopefully losing 10 pounds or so will help when I see the FS? Can you still exercise when on phase 1, my husband and I go to gym together every night and I would want to stop doing that for two weeks because it really helps with the stress?
Kyla thank you so much for your support, it really gives me hope, I have heard that a lot of ladies have boys when using preseed, do you agree?



 
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