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Old Dec 11th, 2010, 04:48 AM   1
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Early Symptoms of Pregnancy <5 dpo

Hello to all you wonderful ladies in the 2ww! I wanted to share a little information I found researching. If this has already been posted, I apologize! I am currently 4 dpo, and have felt like crap the last day and a half. I woke up seeing spots, sick to my stomach, and a massive headache. I thought I was coming down with a cold, but I don't have a sore throat or swollen lymph nodes, so I went googling after I started feeling a little better. I found this in a post on another site:

"After hatching from the zona pellucida, the embryo sends a signal to the ovaries to secrete early pregnancy factor (EPF), which occurs from 1-2 days after fertilization. This EPF begins a dialogue between the embryo and the mother. It is possible, therefore, that a woman who is very sensitive, or is accutely aware of things, may have some symptoms associated with the EPF secretion, although I am not sure if this has been studied."

Then, I decided to look up Early Pregnancy Factor, and this is what I found:

Early Pregnancy Factor (EPF) was first described as a pregnancy-associated substance and its discovery created considerable interest as it enabled the detection of a potential pregnancy within 6 to 24 hours of fertilization in all species tested (e.g., mice, humans, pigs, sheep). Up to this time, it was considered that the embryo was a silent passenger during the preimplantation period and maternal recognition of pregnancy did not occur until implantation. With the discovery of EPF,it became apparent that the maternal system was preparing for implantation and successful pregnancy from the moment of fertilization. EPF is an immunosuppressant by virtue of its ability to release factors, which suppress a possible maternal immune response against the alien fetus.1

Early pregnancy factor in serum has been shown to be a marker of the presence of a viable embryo. In women the appearance of EPF has been reported within I - 2 days of coitus that resulted in pregnancy. In contrast, the earlest detectable concentration of beta-hCG human chorionic gonadotrophin) appears in maternal serum on day 8 following LH peak with most women producing detectable quantities on days 9 and 10 post LH peak. EPF remains in maternal circulation until about the last week of gestation but always disappears from serum before parturition.2

Before implantation, maternal serum EPF does not appear to be a product of the zygote (incorrectly referred to as a "fertilized egg") itself but of the maternal ovary in respose to a signal from the zygote, called ovum factor. Little is known about ovum factor as of now except that it has a relatively small molecular mass and is secreted by the ovum upon sperm penetration. Its production continues until the blastocyst stage of development.3

EPF can be bioassayed using the rosette inhibition test. EPF is expressed as rosette inhibition titer with values greater than 16 indicating a positive pregnancy. It must be understood that the rosette inhibition test embodies a complex cscade of events, which make it expensive to conduct, and the results somewhat difficult to interpret at times.4

Anti-EPF vaccines have been used experimentally. After fertile mating, mice were immunized with anti-EPF and when examined at autopsy at day 10, significant embryonic loss was noted.5 In a study done on a small group of IUD wearers, EPF became positive in half of the group and then disappeared, indicating the abortifacient activity of the IUD during the course of the implantation event.6

EPF is required very early in gestation for embryonic development. It is the earliest serum benchmark to date of positive fertilization and thus conception. Although the rosette inhibition test is costly and still in need of refinement, a study done on women using hormonal contraception would lay to rest once and for all the question of how often ovulation and conception occur and subsequently how often the demise of these pregnancies occur. As one would imagine, the pharmaceutical manufacturers who could afford such a study, are not interested in the information. Now that there is a clear marker available to be assayed, PFLI, Intl. (Pharmacists for Life International) is taking the initiative and insisting that such a study be undertaken in order that a clear and concise resolution to one of the most important questions of all time be resolved - how many abortions are caused by birth control pills.

***Makes me feel a little less crazy

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Old Dec 11th, 2010, 05:14 AM   2
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Thats a good find, it has i suppose helped me understand myself a little more.. just a little information to add to, after you have had your ov day please anyone do not take painkillers stronger than paracetamol, my ivf doc told me that it could kill the sperm/egg or even cause a m/c

thanks for this xx

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Old Jun 4th, 2013, 20:36 PM   3
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Hello lovely ladies! I am new to this... But I am in my 2ww I am about 5dpo. This will be my second blessing! First attempt at conceiving our second child. I currently am suffering from super horrible breast tenderness!!

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Old Jun 5th, 2013, 07:29 AM   4
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Hi WishIwas. Are you able to quote your sources?

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Old Jun 5th, 2013, 09:31 AM   5
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I'm 3/4 dpo and I feel like crap as well. I've had a minor sore throat since sun morning, which could be from smoke inhalation at a bbq sat, but I woke up this morning all stuffed up with a slight tickle in my throat causing some light coughing...any one using femara or ovidrel and know if this is a side effect of either?

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Old Feb 5th, 2015, 22:32 PM   6
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This is awesome news! I have felt crampy in my cervix and uterus since Ov and am now 4dpo. I had a huge headache yesterday and felt slightly nauseous. I was attributing the nausea as a factor of my headache. So, not sure about the nausea. I have a dull fullness feeling in my pelvic area. Did you end up pregnant wishiwas?

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Old Feb 5th, 2015, 23:53 PM   7
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This is a really old post ... 2010.

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