Obstetric Cholestasis & RhD Factors Rhesus

Discussion in 'Pregnancy - First Trimester' started by Jo, Sep 10, 2006.

  1. Jo

    Jo I'm an old bag!

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    Hiya girls/ladies,

    I thought it important that i start this thread as I had this condition when i was PG with Jack and there was very little information about it.

    We all know the signs to look for with Pre Eclampsia but non of the baby books i was given explained about this.

    This condition can be a threatening one to both mum and baby if not treated correctly (please don't be scared).

    I started with mild itching on my arms at about 30 weeks, my MW sent me for blood tests and it was OC.

    Basically it is a blood/ liver disorder flow of bile is restricted as the liver is not fuctioning properly which leads to a build up of bile acids in the blood which is what causes the itching.
    I was given steroids and various other pill and potions (15 a day in all!!) and monitered very closly and the delivered Jack at 37 weeks

    The main signs to look for are ITCHINESS, TIREDNESS(i know we are more tired anyway!) and FEELING INCREASINGLY HOT

    I thought it important to post this now as it could be confused with the warm weather and it would be better to be safe than sorry.

    I am going to put some links up for you if you have any questions please feel free to ask either on here or PM me

    http://www.britishlivertrust.org.uk/content/diseases/obstetic_cholestasis.asp
    http://www.patient.co.uk/showdoc/23068933/

    http://www.bbc.co.uk/health/conditions/obstetriccholestasis1.shtml

    www.itchymoms.com
     
  2. Spunky Cupkake

    Spunky Cupkake Well-Known Member

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    You Your Baby And THe RhD Factor

    Ive typed this because i thought it would explain to mothers about the Rhesus Negative as ive had it but never really understood until i read this leaflet

    A Rhesus Negative Red Blood Cell is just the blood cell

    A Rhesus Postive Red Blood Cell has proteins covering it

    MOTHERS AND BABIES

    sometime during pregnancy a small amount of the baby's blood crosses over into the mothers blood stream. There are a number of ways by which this can happen including normal delivery and c-section or when an amniocentisis is undertaken.

    This is quite unusual and causes no harm because the mothers immune system recognises the baby's blood being different from her own and quickly cleans it out of her system.

    To do this, the mothers immune system produces special proteins called antibodies. These attach themselves to the baby's red blood cells which are in her blood stream and destroy them. This immune response occurs in a similar way when any microbe or foreign body enters the circulation.

    From then on .the immune system remebers that it has been in contact with the baby's red blood cells. So if the same situation occurs again the mothers immune system will be ready to act swiftly and eliminate them.

    However, when a mother is a Rhesus Negative and is carrying a baby that is Rhesus Positive there is a small chance that a problem may arise.

    Reasons why baby's blood can cross over into the mothers blood stream :
    Amniocentisis
    CVS
    Injury to the abdomen
    Vaginal bleeding during pregnancy
    Miscarriage
    Termination
    Child Birth
    C Section


    GIVING BIRTH

    A Rhesus Negative mother gives birth to a healthy Rhesus Positive baby, During birth the baby blood crosses over into the mothers bloodstream
    the mothers immune system gradually responds a destroys the positive blood.

    From now the mothers blood will always remember the positive blood cells

    Suppose the mother came pregnant with her second child who again is rhesus positive. There is a real risk that the RhD factor anitibodies from the mother can cross the placenta and enter the baby's blood stream.

    These antibodies which were produced in the first place to protect the mother, now have the ooposite effect on the baby. They can damage the babys red blood cells. If this were to happen , the bay can suffer a number of life threatening conditions, collectively knows as HDN = Haemolytic Disease of the Newborn.


    PROTECTION FOR THE BABY

    During pregnancy
    When a Rhesus Negative mother is pregnant the hospital can inject a small amount of ready made antibodies at 28 wks and 34 wks of pregnancy.Then if any of the blood has entered the mother circulation during pregnancy the injected antibodies are there to remove the positive blood cells immediately. The injection is known by medical staff as Anti-D Anti-D Immunoglobulin is made from a part of the blood called plasma that is collected from donors. The production of anti-d is very strictly controlled to ensure that the chance of a known virus being passed from a donor to the person receiving the anti-d is very low it has been estimated to be 1in 10,000 billion doses

    After Childbrith
    Hospital will test the baby's blood after birth. If the baby is found to be positive and the mother is negative the mother will be given a dose of anti-djust incase any of the baby's blood had crossed over into her bloodstream just before birth. The injection will removed any of the positive red blood cells. If the mother who has had any of these injections of anti-d gets pregnant again there will be no danger to her baby since her own immune system has not produced anti-d antibodies which might cross over and harm her unborn baby.

    Incidents During Pregnancy
    Sometimes a rhesus negative pregnant woman may need to be given anti-d if there has been an incident during the pregnancy that may have caused a small bleed from the unborn baby into the mothers circulation e.g seat belt injury or vaginal bleeding. It is important that the mother reports any such incident to her midwife as soon as it happens

    i hope this explains about RhD Factors and make some sense about being rhesus negative .

    spunky xxxxxxxxx
     
  3. Carley

    Carley Mama to one and pregnant

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    I am a RH- Mama A-. I had many Anti-D's in pregnancy from bleeds.
     
  4. jaya460

    jaya460 Member

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    i am also RHnegative carrying quads.

    jay
     
  5. holly

    holly Mummy to a prince

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    i have just found out i am also negative but am very worried as when I had a miscarriage in decmeber they didnt know my blood type therefor i didnt get the injection....does anyone have info on this? could it harm this baby? xx thanks!
     
  6. jocatolo

    jocatolo Mum of 5

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    Hiya I'm RH neg and had previous miscarriages now and wasn't given anti d after mine and asked about it at the time as i knew and the hospital told me that before 12 weeks they don't give anti d injections, if you have any worries tho just give your midwife a call. Good luck x
     
  7. joannek

    joannek Member

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    I am also rhesus negative, i just had a misscarriage, i was given antid when i went in to the er with bleeding. I am very concerned that there is some kind of problem with this blood type and would like to find out if there is greater risk of misscarriage when you are rhesus neg, as my mum is the same and had three misscarriages after having me? Anyone help?
     
  8. nervousnrg

    nervousnrg New Member

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    I don't think RH neg can cause higher incidence of miscarriage but would be interested to find out if it is the case?
     
  9. Vivanco

    Vivanco Well-Known Member

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    Hi, i am RH neg, but have never been given anti-D after a m/c!! I told them everytime and they said 'not to worry' i has a blood test after the birth of my daughter and they said it was very strange but it looked as though my body had stored the anti- D i had been given in pregnancy!! They were baffled.

    I am a little worried this time as my daughter is a different blood group to be (which is the problem) she was a little poorly after the birth and was borderline jaundice, although then the consultant did say it was because she is mixed race and her skin could jut be tinted because of this!! (professional) lol. but she was strong and just scraped by without needing the light therapy, we were allowed to go home after 2 nights. She is fine though and my m/w kept a very good eye on her for the few weeks following her birth.

    x
     
  10. itsmarshall

    itsmarshall Pregnant - 1st Trimester

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    I believe that when you are rhesus negative the blood from the baby may flow into your blood stream and creat anti bodies, as you had the anti-d you shouldn't have any problems, if you don't have it I think the blood may pass through a second time causing the anti bodies to multiply and therefor attack the babies blood cells, this can be harmful but as long as your mw knows your full history she would have made you aware of any problems, definately speak to her if yur worried though as this gives negative vibes to the baby... good luck! x
     
  11. Vivanco

    Vivanco Well-Known Member

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    I asked if the reason for my 3 m/c's was due to being RH neg, but the consultant said that as the m/c's were all before 12 weeks it was extreamly unlikely x
     
  12. massacubano

    massacubano Guest

    add me to the rh- club too! I am glad my DD is rh+ she won't have to deal with getting shots (jabs).
     
  13. Mrs_Nesbit

    Mrs_Nesbit Mum of 3 hoping for 4

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    Rh - here too with two Rh + children. After my first child I've been sure to let the MW know my blood type straight away just to be on the safe side.
    OH's mum's Rh neg too and sadly an only child due to his mother suffering an awful amount of early and late MC's and one stillbirth before he came along. As he's 44 then it's very likely her Rhesus factor and lack of Anti D at the time had alot to do with her losses.

    We are fortunate to have modern medicine on hand to help us.
     
  14. Kayleigh Lou

    Kayleigh Lou Well-Known Member

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    So nice to have people on here that i can talk to about this. I am also A- and have had two children. My doctors didnt really explain much to me, just that i had to have these injections to stop my body from rejecting my babies. That was about it!!!!
     
  15. babybump4

    babybump4 pregnant with #4

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    hi i am aso rhesus negative i am 5 weeks preg with my 4th baby all the females in my family are negative and none of us have had any problems with my 3rd child i had a bleed at 12 weeks and was given anti-D they dont give it you before then hope this helps.
     
  16. Samantha87

    Samantha87 Well-Known Member

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    Sorry for barging in but this thread caught my eye. I lost a baby at 7 weeks. I am also required to get the shot. Nothing was given to me. no shots....should i be worried? I'm worried about future pregnancies :blush:
     
  17. donedu

    donedu Guest

    i am b rh +.
     
  18. donna b

    donna b married with one daughter

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    i had OC with my first baby and am now expecting again, so am very aware now of what to look for whereas when i had my daughter, it was something that wasnt covered much in any pregnancy books at all!
    keeping my fingers crossed that i will be ok, but at least i know that if i get it this time round, i will be monitored and watched closely xx
     
  19. leigh123

    leigh123 Member

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    Hi I just wanted to let any Rhesus negative moms who have anti bodies there is the most wonderful supportive group on facebook RHESUS DISEASE which is helping moms goping through pregnancies with anti bodies etc. i felt very alone til I found the group.. x
     
  20. bubba2

    bubba2 New Member

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    Hi, i am 29 weeks with mt second and had this the first time. I am currently on medication and bile acids have started to come down. Just wondering what level your bile acids were at when you had Jack and did the medication work for you? Just wondering if i will still be induced if they start to come down.
     

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