Found this on the net.......
First of all, what is PAI-1? The best way to explain PAI-1 is to describe what it does. The blood clotting system is made up of many different factors, some which cause a clot to form and others which cause the clot to breakdown, and these coexist in a very delicate balance. When the blood clotting pathways are activated, fibrinogen, a soluble plasma glycoprotein, is polymerized to form fibrin which is then cross-linked by the action of factor XIII to form the clot. Under normal circumstances, as soon as a clot forms, it begins to be broken down by other plasma factors. Specifically, a substance called tissue plasminogen activator (tPA) converts an inactive plasma protein, plasminogen, to the active substance, plasmin, which then plays a critical role in the breakdown of fibrin (fibrinolysis), thereby dissolving the clot. (Interestingly, and perhaps germane to our discussion at some later point, plasmin also plays important roles in ovulation, cell migration, and epithelial cell differentiation).
Read more: https://www.healthline.com/blogs/pr...ctivator-inhibitor-1-pai-1.html#ixzz1I6vxD78O
Healthline.com - Connect to Better Health
hth
, but I'm happy they checked. You may wanna ask if you can be checked for PAI-1 if this doesn't put you at ease. I do remember the high risk doctor saying that it's inherited and if i had any sisters they may have the same gene as well. So if you have any sisters that had normal pregnancies then you're good to go, never hurts to check though. I've been researching PAI-1 and found out that women who carry that gene often have a difficult time getting pregnant... which would explain why my ex and I tried for four years with no success. Happy he's not around though because I'm sure he'd thrashed very well for putting his *baby* in danger LOL... any who good luck! how many weeks are you?
