Recurrent Miscarriage Thread

Hello all,

My pregnancy tests have just started getting lighter which means miscarriage number 3.

Feeling incredibly broken and despondent. I can't imagine ever having a healthy baby.

So far my test results have been fine.

I do have PCOS but not the problems that are associated with miscarriage ( testosterone is fine, SHBG high (as opposed to low), no insulin resistance).

Can't believe I've just been unlucky though!!!

Can anyone recommend what tests to go for next?

And anyone in the UK able to recommend a recurrent miscarriage clinic in London?

Sorry for all your losses.

Thanks xx

Hi Lou

If you are based in London area then I would ask for a referal to Mr Shehata at Epsom General

I was referred to him by my GP after my 6th miscarriage. He tests for NK cells on the nhs which no other doctor tests for unless you pay for it privately . After seeing him I carried my next pregnancy to 27w, I suffered a placental abruption and we sadly lost isaac after 3 days in nicu. I then carried my next pregnancy to 36+4 . My little miracle Oscar is now 6 months old . Your gp might try and get you to go to St Mary's in London but I would definately go to Mr Shehata instead xx

He carries out all the other standard tests too but does the nk cells as an extra test and he has had really good success xx
 
Trying, that's great news that your hysteroscopy came back clear. No further surgeries needed!
As for trying again, I would suggest that you wait for the karyotyping test to come back. This was from your last pregnancy, right? If the results show something abnormal it was bad luck and you can try again. If the results come back as normal, well, I'd say there's still something wrong but your doctor hasn't identified it yet. You need to change something.

Thank you. I am so pleased that no more surgery is needed. It is such a huge relief.
We said about waiting for the karyotyping, from the last pregnancy. But we got carried away after a few drinks on Friday night :wacko: I took an OPK yesterday and it was a blazing positive. We are not super fertile, so its very unlikely that we would conceive so soon so I'm not going to worry.
Hoping these results come back soon
 
I'm not based in London. I'm in Eastbourne in East Sussex. I don't think my local hospital has a recurrent miscarriage clinic.
 
I'm not based in London. I'm in Eastbourne in East Sussex. I don't think my local hospital has a recurrent miscarriage clinic.

It doesn't matter that your In East Sussex, I'm from the Midlands (Nottingham/derby) and my gp referred me to Mr Shehata

I thought you was based in London because you were asking for clinics in London

Xx
 
I had 3 mS IN PAST 1 AND HALF year and now im expecting again (littleover 6 weeks) i can tellyou that baby aspirin, folic acid and progesterone helps a lot...especially progesteron as its supporting your pregnancy. My friend deliver twin IV AND SHE COULDNT TAKEIT TO TERM without progesterone.

Goodluck
 
Hey ladies :hi:
I'm off to the open eve at Dr Shehatas clinic this Thursday. :happydance: Be interesting to find out a bit more.
For those that took baby asprin, can you get this yourself over the counter? Will they ask questions or will they just hand some over ? I wanted to give it a go the next time we fall pregnant.
 
Just off the shelf in tesco so no questions asked. It's a yellow box with a heart on it. Good luck at the open evening xx
 
Hello all, as I try to work my way through the 2300 pages of this thread, I thought I'd say hello and post some of my info, in the hope of getting some insights that could help with my situation.
But first, I am so sorry to read about all the loss here. My husband and I understand much of the pain.
I am late-30's, as is my husband. Back in our early 20's we experienced 6 mc's, over the course of a few years, all discovered at almost exactly 10 weeks, after which we gave up trying for a long time.
Back at that time, our mc's were chalked up to my immunological response to the placenta. Category II antibodies to phospholipids & Category V elevated CD 56+ natural killer cells and elevated CD 19+5+ cells. I was treated with heprin, aspirin and an immune suppressant drug, humira.
None of this worked and I had a tubal ligation.
Fast forward to last year. We had a friend kindly offer to GC for us. My husband and I both underwent all the health pre-testing required by California. We both had FDA STD testing. I had some immune assays done - TH1:TH2 cytokine ratio. Also Consyl Family Prep screen. We were told that we checked out - that we were good to go - that we'd have the normal chances of other couples, that my auto-immune issues would no longer be in play.
Our GC has had two successful, easy births. The last was around a decade ago. She is now 35. Unfortunately, she ran in to the same problem we did all those times - miscarried at 8 weeks or so. We think if she weren't getting such frequent US, that she might have found out around 10 weeks, like we did. So, this causes us to fear that our problem way back when might not have just been my immunity, but rather, maybe something about our genetics causes mc around 8 - 10 weeks.
We are willing to get whatever testing done that we need to. Just looking for guidance as to what to ask for.
We just lost 2 embryos (the clinic tried a double implant, because of our age they said). We have 5 more. 4 mid-grade, 1 lower grade blastocysts.
I should point out our GC experienced a uterine aneurysm (small subchorionic hemorrhage) at around 6 weeks. We were told that is was likely non-problematic. Our two little ones had healthy hearbeats right around 8 weeks, then by the time of our next test at 9 weeks their heartbeats were gone. This was just around 4 or 5 days ago. We are quite heart-broken.
Our GC also had a 4.5 cm cyst on one ovary, but we were told that was not a factor. Her blood tests checked out, but maybe we should have treated the cyst before implanting? Maybe we should have monitored hormone levels more closely?
If we need to, we may look in to donor egg or donor sperm. Our GC is willing to get whatever testing we'd like. She will probably D/C soon. She is also willing to help us try again.
Any advice is greatly appreciated. Sorry if any of this is unclear. I am more than happy to clarify anything.

Thank you,

QoC
 
Queen- I just wanted to say how sorry I am for all of your loss and heartache. I don't know what tests to ask for but wanted you to know you are in my thoughts.
 
Queen- I just wanted to say how sorry I am for all of your loss and heartache. I don't know what tests to ask for but wanted you to know you are in my thoughts.

Thank you. Our GC's appt today confirmed our fears, of course. She D/C tomorrow and the dr. agreed to run a chromosome test. He says the results likely won't be helpful, but I think we scared him a little or he at least had some sympathy for our obvious passion.

Our main plan is to get full genetic testing (husband and me), whatever that means. I can't believe, with all of our troubles, to this point, that that was never done... Oh well. We do the best we can in the moment. Just makes me worry - will we finally ask the right questions this time? Will we get meaningful answers?

Our GC is willing to keep trying, as soon as she can, with our remaining embryos. My husband and I are willing to do that as long as our genetic testing doesn't reveal some horrible "smoking gun" in either of us.

Again, any advice appreciated. Is there some connection between 8 - 10 wk MC and some particular gene? We've read a lot about tranlocated chromosomes and the C4M2 gene...
 
Just off the shelf in tesco so no questions asked. It's a yellow box with a heart on it. Good luck at the open evening xx

Thanks Tash :thumbup:
I just googled it so i know what I am looking for. Next time I am in there I will pick some up so at least I have it ready.
How long should I take the asprin for and do you just take it after BFP?
I hope you don't mind me asking all these questions xx
 
Queenofchaos I can't offer much advice but I wanted to say sorry for all you have been through. I really hope that you get the answers that you truely deserve :flower: X
 
Queen of chaos, I don't have much advice either. I think someone was talking about blood clotting testing done on the husband too, way back in this thread. Another angle to look at perhaps.

You're welcome trying. For myself I was on them every day whilst ttc but I've multiple clotting disorder and very sticky blood. Most people take from bfp as there is a train of thought that too thin blood can affect implantation.
 
Hi Tasha. Thank you again.
I will take from BFP as I have no known clotting issues. I just wanted to take it as I know that in some cases it can help. I need to change something each time. This time I will also continue with the Omega and D3 throughout. Last time I stopped as I was initially using it to help with conception. But since I have found out I can take in pregnancy too x
 
Hey, been told embryo is measuring a week behind so I expect to miscarry in the next week or so. In order to get this embryo tested as it's (number 3 miscarriage) do I have to have the ERPC?

Sorry for alll your losses x
 
Omega is really good for pregnancy. Is D3 vitamin d? If so vitamin d deficiency is a known cause for recurrent miscarriage. Another simple thing to try is high dose folate/folic acid if your doctor will agree.

Lou I won't give up hope for you since mm's mean a weeks difference in early pregnancy. You need to ask your care provider since some will only test from a d&c and some will do it if you catch the baby in a sterile pot.
 
Lou-I too will keep positive thoughts going for you and this little bean. With dd I knew exactly when I ov and implanted and she still measured a week behind. At 10 weeks she caught up. Fx'd all is ok.
 
Hi Tasha
I read about the Vit D thing so will carry on taking next time. Can I just take an extra folic acid or is that too much?
Went to the open evening at Dr Shehatas clinic. Was ok but didn't find out nothing I didn't know already but was good to see it all.
One thing though, when I was asking questions I was asked when my last MC was. He said oh that's ok then as after each MC it takes longer to fall pregnant. This took me back a bit and I didn't ask why. So now I am really upset this evening as I feel I should give up hope of having a BFP anytime soon. Last time it did take us much longer so maybe there is some truth in it :cry:
Sorry just feeling very deflated this evening and fed up X
 

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