My daughters are 4 and a 2 1/2, and I work full time, but I am never without my youngest, and my 4 year old is away only for preschool.
I have done a number of things since having them- watching kids in their home or mine, baked soft pretzels and sold them at a farmer's market (and made a surprising amount of money) and now I work at a fitness center that has a drop off multiage nursery (I bring my girls with me), and then I work at a preschool in the afternoon (in my younger daughter's class).
I'm going to tell the director there soon that I'd like a part time job in in the infant room as soon as one becomes available so that when the baby is born, I can be in that room.
I know that my situation might be really specific, but except for 1 1/2 years out of the 4 1/2 that I've had kids, I have been working and my girls have never been in daycare, had a babysitter, etc. I have just been determined to make it work! Applied to a lot of jobs over the years, turned down many, and in the end it has always worked out okay!