Ok Girls, I'm desperate... why is it that sometimes when I take Zofran it helps alot, and other times I may as well not have taken it for all the good it does me?? Is there some sort of 'trick' to taking it, like before you eat instead of after, or under the tongue instead of on top, etc... ??? I swear I can't take another minute of constantly feeling on the edge of barfing. I just want a NORMAL life, and to eat NORMAL food. Also, do you know, does it help to take more than one tablet at a time? Does that make you MORE constipated? (is that even POSSIBLE??) I've read some people saying they take 8 mg Zofran, mine are only 4 mg... is taking two worth it?