I currently take a baby aspirin a day,I started after my mc and got my bfp. I will continue through my pregnancy until I reach the 3rd trimester. Be sure and let her know its baby aspirin not regular aspirin, 75 - 81mg. I'm not a Dr so all I can offer you is what my obgyn suggested and what I'm going through at the moment. Hope this helps in some way. Some things to help with your progesterone are vitamin b complex, maca, a diet high in fruits and vegetables has been known to help raise progesterone, and I read somewhere flax seed oil can do this as well. I am currently taking prometrium for this pregnancy which is progesterone prescribed by my dr. I'm sorry about your sister, tell her to hang in there and do extensive research before she trys anything, I went through a process of elimination. Personally vitex didn't work for me, it screwed up my cycles but I know others it has worked for. What I found that balanced out things for me was taking EPO (evening primrose oil ) from the day AF started until "O" you don't take it after ovulation as it can cause little contractions and interfere with implantation. I also took Damiana from day 1 until ovulation, it strengthens the egg and improves your overall fertility. By all means research, research, research as some things work for some and not for others. Send your sis hugs.....