I tell ya, us LTTTCers sure have to endure a lot, that is how I KNOW we are going to be great mothers
. I actually told my boss what was going on. I felt that it was important that they understood how crucial it was for me to make appoitments. Not only that, but my RE is 150 miles away from where we live so that is 300 miles round trip! Now, it depends on what kind of relationship you have with your boss. I have a good one, and he know me and my DH very well. Him and his wife are childless due to infertility as well, so of all people, he completely understands what we are going through.
I know that telling the boss is not practical for everybody because for one it is very priavate and embarassing, and some supervisors may treat you different. The boss I am talking about is the assistant director of my place of employment. The director is a complete jack ass, in fact, in August when DH and I were successful with our second round of clomid (after 6 years of ttc) he made it really difficult for me. He would give me a hard time about being pregnant and when I sadly miscarried that same month, he gave me crap about having to leave work (my miscarriage started while I was at work).
Anyway, that is my opinion. It is entirley up to you how you want to handle it. I don't like discussing my infertility with many peoplen because I can do without the comments and opinons of others. Us LTTTCers have the right to have children just like everybody else on this planet, and the only way we get our chance is going through all this doctor stuff.