my 3rd ICSI was under a dnew doctor and he did several things differently. One of them was, to put me on Metformin. I am not overweight (110lbs @ 5'5") but I do have mild PCOS. It didn't make me lose weight, but was for the sole purpose to regulate my insulin. It didn't cause as many / bad side affects that many of you have faced...just made me more tired. However, this time, Egg collection (30 eggs) was almost painless while in the last 2 ICSI's, I was bedridden for a week. I got preggo. So I believe it truly helped.