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Need Advice on Progesterone Supplements.

Mrs Reineke

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I wanted to get your ladies advice or knowledge about taking progesterone or not during the first trimester of pregnancy. I am 31 and my husband is 33. We are trying for our 1st and neither one of us have kids. I have had 2 early miscarriages, one at 5 1/2 weeks and one at 6 weeks. We have been able to get pregnant super easy, just haven't been able to stay pregnant, so I am curious as to what you all think I should do. I know you're not doctors, but we all go through a lot and learn from our experiences, so I'd love any help or advice you may have. I have had a bunch of tests done after bothering my doctor about it. Here is what I have had done and the results.

Thyroid-normal
FSH (CD3)-normal at 7.9mIU/mL
Estradiol (CD3)-normal at 54pg/mL
Progesterone (CD21)-normal at 13.36ng/ml
AMH (CD3)-normal at 1.79ng/ml
I have Factor V Leiden heterozygous-blood clotting disorder that I normally don't have to take anything for.
Anticardiolipin Antibody test came back slightly abnormal-blood clotting disorder that I was told can increase in pregnancy. I will have this test re-done as soon as I get a BFP and if it's increased I will be put on Lovenox.

So with all of these tests done the only issue here that I see is the 2 blood clotting disorders, otherwise all of my tests have been normal. So what I am wanting to know is I've read so much about ladies being put on progesterone supplements for the first 10-12 weeks of pregnancy, but most of them are put on it because they have low levels of progesterone or a short luteal phase. Well with mine being normal on CD 21, should I even worry about bothering my doctor to put me on it anyways even if I don't need it? I always have normal 28-30 day cycles and ovulate around mid-month, so I do not have a short luteal phase. With my 2 miscarriages I started to spot and went into the doctor and with my first my HCG level was 15 (considered negative) and my progesterone level was at 1.28ng/mL, so in the range it would be when I first start my AF. With my second miscarriage my HCG levels were a tad higher at 44 and then 74 before I started to spot and when I went in my progesterone level was at 3.73ng/mL which is less than what my paper shows is normal for the first trimester, but also higher than my previous mc. I know progesterone levels will drop if the pregnancy is not viable and a mc is coming, but I didn't know if they would just drop on their own even if the pregnancy is good and then cause a mc?? I don't think this is the case, but I'm not sure. With both of my mc's my HCG levels were pretty low I think and therefore I believe neither of them were viable from the beginning. So after all this babbling, what I want to know is can progesterone drop even if the pregnancy is good and then cause a mc, should I be put on progesterone even if my levels are normal, or is it most likely my 2 blood clotting disorders that are causing my early mcs due to tiny blood clots causing issues with proper implantation and/or circulation to the baby? I wasn't doing anything special with my 2 miscarriages, just taking a prenatal vitamin, but now I am taking a prescription prenatal vitamin with more folic acid in it, omega 3's, vitamin C, 1 baby aspirin a day and then if my Anticardiolipin Antibodies increase when I get pregnant again, I will take the Lovenox shots. So, what do you ladies think??? Thanks in advance!!
 
Hi,

Sorry for your losses. Personaly i d would ask for the progesterone. I ve recently gone privately to a top miscarriage clinic in london after just one miscarriage but delayed fertilty (18mns to concieve 1st, 6mns for 2nd which i miscarried at 9wks and no luck so far now 7mns later).
Their standard baseline protocol for all patients is prental, vit d 2000-5000iu, omega 3s, 75mg aspirin once daily and progesterone from positive test. If bloods show clotting problems they ll prescribe injectables and if immune issues then prednisolone poss plus intralipids or immunoglobulins.
My last day 21 progesterone was 72 nmol/l (which is 22 ng/ml) and was considered a good level and i have a 13-14 day luteal phase but they said i would still be given progesterone from bfp. Hope this helps and good luck.
 

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