When given to mice in very high doses (up to 2% of body weight), raspberry ketone has been shown to prevent high-fat-diet-induced elevations in body weight.[8] However, no effects on body weight were observed with doses up to 200 times greater than the estimated intake in humans.[9] The high dose effect is reported to stem from the alteration of lipid metabolism, increasing norepinephrine-induced lipolysis. Although products containing this compound are marketed for weight loss, there is no clinical evidence for this effect in humans.
got this off wikipedie - says no preven effect in humans