My husband has a balanced translocation on chromosomes 1 and 4.
My son had an unbalanced translocation on chromosomes 1 and 4. He only lived seventeen days due to the severity of his heart and brain problems.
We're sort of TTC without IVF/PGD because of the expense involved. Its scary to think of it happening again, but we feel like we'd always wonder if we didn't try again. That being said, if it does happen again, we're done.
There is a specialist in New York and gave us the percentage of it happening again and miscarriage rates and stuff. We know we don't have much of a chance, but feel we have to try. Risk of miscarriage is 30%. Risk of some kind of genetic issue (balanced translocation, unbalanced translocation like my son had, or the opposite issue) is 13%-26%. I'm not sure why there is such a range.