Any underweight/very slim moms to be

I was underweight at the start of my last pregnancy (112lbs 5'7") and had very bad morning sickness. It didn't ease off until nearly 5 months when I still continued to be sick but not every day. I can't remember what my BMI was but it was low enough to trigger an appointment at the hospital, ironically at the obesity clinic! I just found it so hard to eat and keep anything down plus I'm a dance teacher so am very active. This time as soon as I found out I was pregnant I tried to eat as much as possible and I'm already up 6lbs compared to last time. I haven't been quite so sick either and my eating is marginally better than before. I had my midwife app on Monday and she remembered me from over 3 years ago as I was measuring small. She said she was worried about me last time and this time although it's important to keep active I mustn't over do it.
 
Hi mummy3,

Congratulations on a little girl!!! :baby:

When I went for my Nuchal the lady told us she thought it was a boy and she wasn't a sonographer she was a specialist who used to be an OB and then when I went to see my OB I mentioned it to her and said I didn't think you could tell that early she said sometimes if it's obvious gave me an ultrasound and said she thinks the same! So I guess we will see.

Balanced Translocation is hard to explain but it means when my husband was an embryo 2 of his chromosomes snapped off and they translocated to the other side and rejoined so basically two of them traded spots. It doesn't cause him any problems but when you go to have a baby it can because each chromosome means something different the two that broke for him basically mean 75% chance of miscarriage each time but they should usually all end around the 6-8 week mark if theres a problem.

It is rare probably sounds weird haha and I'm probably not that good at explaining it. We had a geneticist explain it to us and he was good at explaining it all.
 
mummy3: yes I'm just slim...and short (5'2'' and 95lbs...now down to 91). I'm trying to gain a little but honnestly I'm so tired and it's so hot that I don't really feel like eating anything. But I was very lucky I never got morning sickness with my girls:)
 
translocation in general is when a part of one chromosome breaks off and attaches to another another, ie. your chromosome 18 breaks one of its extremities and it attaches to your chromosome 13.

when it's balanced, it means that also another translocation occurs: a piece of your chromosome 13 breaks off as well and glues to the chromosome 18 that was already broken.

so in the end you get to keep all your genetic material. this happens usually as she said at an embryo stage, and since all the genes are there, the embryo develops normally and then the person carries it without knowing (unless the break occurred in the middle of an essential gene and fucks up its function).

the problems occur only when it comes to having children, as in her OH's case, when the sperm is made you have 4 options: a sperm has both translocated chromosomes, or translocated 18 and normal 13, or translocated 13 and normal 18 or both normal 18 and 13.

so this is why 75% chance of miscarriage: when sperm fertilizes a normal egg, male and female chromosomes pair between them and are supposed to mix (recombinate) to generate a new mixture of genes - your baby. the thing is, when all chromosomes are normal, pairing goes well and you get all the genes present in two copies, one from the mom and one from the dad.

but when you get these translocated ones... well the mixing part doesn't go well as ie. when two chromosomes 13 are joined to mix, one normal from the mom and the other from the dad with an extra piece of chromosome 18 attached ...
many errors occur, parts of genes on chromosome 13 are lost and the genes from chromosome 18 are overdosed (as they end up being present not only on both chromosomes 18 that already come from mom and dad alone, but plus they also end up being included in this weird chromosome 13 mixture now).

so the embryonic development can't proceed anymore beyond certain stages... usually 6 to 8 weeks when main organs and systems of organs start to define.

:) hope this was clear :)

i hope you can see the pic, i tried to post/upload but it didn't work :)

https://upload.wikimedia.org/wikipedia/commons/c/cb/Translocation-4-20.png
 
Yes skyesmom has explained it much better then me haha! Thanks that is much clearer :thumbup:
 

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