Clomid, endo lining, progesterone questions.

[LouOscar01]

Hello All,


Long message...I've coloured my questions blue in case you don't want to read my essay!!

I am currently 7dpo on round 3 of 100mg Clomid. 13th month of ttc...but really only 3rd as it's only the 3rd time I've ovulated.

I have lost all hope though. I feel so down and depressed and hopeless. I know I shouldn't because there's no reason to suggest it won't work. I've always had this feeling that I will never have a baby since finding out I had PCOS at the age of 14. So far everything that has happened as just proven me right. In my mind I have as much chance of becoming a famous singer as I do getting pregnant. Pregnant women have 'celebrity' status in my eyes. It just seems so unobtainable.


I've had follicle tracking this cycle which has confirmed ovulation. My lining was only 5mm on CD10, 6.5mm on CD 15 and 7.8mm on CD22 (5dpo). The sonographer said that my lining was exactly where they would expect for this point in my cycle but I've read that it needs to be 8mm to be viable for implantation.

Can anyone shed any light on this? What is a good endometrial lining?

I also have a very slow rising temperature after ovulation which I've heard can be a sign of low progesterone. It always reaches a high level but usually not until 8dpo ish (my chart is attached). First cycle my 7dpo progesterone test showed 35. I'm having another test for this cycle today.

Has anyone in the UK been provided with progesterone supplements?

My gynae has said that she is happy for me to take Clomid for 12 cycles. Has anyone else had this option? I've heard that 6 is more sensible. I want to take it for 12 as I'm ovulating each cycle so far and want the most opportunities I can get before IVF.

Anyone know what happens on NHS after clomid? Straight to IVF? Or is Femara, Gonal F or IUI offered before?

I'm 25, PCOS (only small cysts at present), 3rd cycle on 100mg (50 didn't work), healthy BMI of 23.3, lining supposedly 'ok', progesterone 'ok', OH sperm analysis was normal, we have sex 3-4 times in fertile period, using OPKs, follicle tracking scans and BBT to confirm ovulation and time sex, use softcups and preseed and lie down for an hour after sex with legs elevated for part of that....

So why am I not pregnant? What am I missing? What else can I do? What other reasons could there be for not getting pregnant?

I'm having a laparoscopy in a few months but I've never had any STI's so shouldn't have any tubal defects.

I wonder if I had a chemical pregnancy last cycle as my period was 5 days late and I had sore boobs like never before as well as a triphasic chart. I was too scared to test though and then spotting began.

Finally, I'm finding this really hard to deal with as always everyone around me falls pregnant really easily and I'm a teacher in an infant school so there's a steady stream of babies and pregnancies among parents too. I was on anti-depressants before TTC but came off it because I didn't want to harm any potential baby but this is affecting my life to a ridiculous extent. I don't want to leave the house for fear of seeing babies/pregnancies and I'm so despondent about life. I need to go back on the anti-depressants. Will they affect Clomid or chances of pregnancy?

So sorry for the essay...I've been avoiding baby and bump for a while and am consequently full of questions.

 

[TTCsince626]

Some great questions wish I knew the answers .....

I can completely relate to you...
After I met with a reproductive endocrinologist it made me much more hopeful. There's so many possibilities out there. We have to stay positive.

 

[LouOscar01]

TTCsince626

The thing scares me about IVF and IUI is that you get so few chances to get it right. A healthy couple can take up to a year to get pregnant but we have 2 chances at getting pregnant with IVF. I know they take out a lot of the hardwork but still...

 

[LouOscar01]

No one knows the answer to any of my questions ?

 

[alicea]

Hey didn't want to read and run. I am just starting my fist cycle of clomid so don't have much advice.


1)Can anyone shed any light on this? What is a good endometrial lining?- Im afraid I have no idea about this

2)Has anyone in the UK been provided with progesterone supplements?-u can get progesterone supplements but alot of GPs don't want to prescribe them, u can buy progesterone creams online from amazon.

3) My gynae has said that she is happy for me to take Clomid for 12 cycles. Has anyone else had this option?-it's unusual to take them for that long due to the health risks.

4)Anyone know what happens on NHS after clomid? Straight to IVF? Or is Femara, Gonal F or IUI offered before?-they might put u on metformin with clomid. Iui is normally for those whos partners have low sperm results.

5) So why am I not pregnant? What am I missing? What else can I do? What other reasons could there be for not getting pregnant?- I am on 50mg a day at the moment. I also taking 'seven seas trying for a baby' vitamins they have very good reviews. Maybe try them out

Hope this helps even if it's just a little xx

 

[bunyhuny]

I'm sorry you're going through this, hun. IF sucks and I wouldn't wish it on anyone. Clomid can be a real pain and for some it works and for some it doesn't. If it hasn't worked within 6 rounds, I wouldn't think you have much of a chance of it working in the future.

For lining: My RE likes to see a lining of at least 8 before triggering ovulation, once ovulation happens, the lining plumps up even more, so it should definitely be thicker than 8mm at 5 dpo. Yours is definitely a bit on the thin side, which is a normal reaction to Clomid but can most definitely prevent implantation. I would not do another round of Clomid at this point. You could ask to switch to Femara; it doesn't have the same lining issues, but it generally only produces one follicle, not multiples.

As far as IVF goes, yes, it's true that a healthy couple takes around 6 months, possibly up to a year to fall pregnant, but that is because not all eggs are good eggs and not all embryos form correctly. In an IVF cycle they take out many eggs at once (I usually get about 20 eggs, so that's like 20 months worth of chances). Even just getting a dozen eggs is like getting a whole year all at once. Then they fertilize them and only about 20% make it to the 5 day stage. Those are your healthy embryos that would generally make a pregnancy in a healthy couple. Then they transfer only those super healthy looking ones. My clinic has an 80% success rate on first time transfers in moms under 30 when transferring two embryos. There overall success rate (including older women and couples with incredibly bad infertility is almost 50% overall. I guess what I'm trying to say is that if you're going to get pregnant by IVF, it doesn't take a year of treatments- the average couple takes 1-3 cycles.

I don't know about NHS, so I can't be very helpful there. I'm sure they'll direct you to whatever they feel the next best step is, and that's going to vary from couple to couple.

 

[lisap2008]

What is a good endometrial lining?
Generally, 8-13 mm is good, less than 6 is potentially a problem, and greater than 15 or so might possibly reduce chances for successful pregnancy. So your lining is not too thin for implantation.

Has anyone in the UK been provided with progesterone supplements? I am not in the UK but I am sure if you cant find a doctor to prescribe it you can order the pro-gest cream from amazon.

My gynae has said that she is happy for me to take Clomid for 12 cycles. Has anyone else had this option?
Clomid is generally not recommended for more then 6 cycles at a time because clomid is known to thin the uterine lining and make CM dry up making conception more difficult over time. In addition, a study done many years ago indicated that women who used Clomid for more than 12 cycles developed an increased incidence of ovarian tumors.

Anyone know what happens on NHS after clomid? Straight to IVF? Or is Femara, Gonal F or IUI offered before?
Not sure about NHS but I would move on to injectables with IUI before IVF.


So why am I not pregnant? What am I missing? What else can I do? What other reasons could there be for not getting pregnant? have a HSG done .try a month without preseed? I have read on amazon of people using it for months and not falling pregnant till they stopped using it.