I was TTC for almost three years.
It wasn't DH's sperm for us, it was my mucous. We would do what are called postcoitals (it's what it sounds like it is, they would check my cervix the morning after having sex) and they found that my mucous wasn't super friendly.
To be COMPLETELY upfront, there are a lot of people who don't believe that postcoitals mean anything. There are studies that show both ways. But there is no doubt in my mind that they were real for us, because I was making good eggs, and releasing them on my own.
When I started used PreSeed, my postcoital tests were better. I mean, they still weren't good. But they were better. Coincidence? Maybe. I doubt it.
The way they treat what they call "a hostile environment" (worst name ever) is with IUI because it allows the sperm to skip right past the cervix.
Okay.... so the month we got pregnant we DID do IUI, but the timing was off. We were supposed to go in on Wednesday morning, but I had a strong feeling that was going to be too late. So i went in for an ultrasound on Tuesday late afternoon and I was right, I had already ovulated (probably as early as Monday night). They said, well, we already have everything, we could just do IUI anyway (since my insurance covered it and the actual IUI part is literally a NOTHING procedure)
So my IUI timing was likely off. BUT, we had used PreSeed the night before.
I remember sitting with my husband at dinner that night, trying to have a good attitude about the whole thing. I laughed and said... "well, if we get pregnant this time, I think it'll be because of the PreSeed, not the IUI"
And to my complete SHOCK, I was pregnant that month.
For slightly more background, I was also taking progesterone supplements, because mine was low and I had a short luteal phase. But I had been taking progesterone supplements (prescribed ones, not over the counter ones) for years. Dosages had been changed a few times, so I'm sure that had something to do with it as well.
But suffice it to say I am a HUGE advocate of PreSeed. It was easy to use, not expensive (especially because I used about a third of the amount that the box says too) and it felt good!! I liked that you could put it in about 15 minutes BEFoRE having sex. It made things feel more natural.
Everyone is different. But I personally saw direct evidence of it making a difference for me with my postcoitals. To reiterate, it did not FIX them. They still wanted me to do IUI. But it was better.
I certainly wouldn't use it in replacement of getting fully checked out. I wish I had gone to a fertility specialist sooner. I thought it would make the whole thing seem more ominous and scary. It did the opposite. It made me feel more in control and like I had a plan.
Good luck to you in whatever you decide. There is certainly never any one right answer.