hormones and recurrent m/c

[cherry22]

Hi ladies,

Just a quick question, i have my results from the recurrent m/c clinic next thursday, Im convinced its my hormones that are the problem as i have pcos.
so does enyone know what can be done so i can carry to full term? eny medications?
has enyone been through this because its all new to me?

half relived, half sared to death.

thank you.

 

[shalagirl]

Hi Cherry22 - its good that they are investigating the cause of your misscarrages. I can't answer your questions I am afraid but would also be interested to read which medical support others got to help them carry full term. I hope your get some answers and help that led to a successful pregnancy.

 

[Dilek]

Hi

Im sorry about your mc. Ive unfortunately have had 1 myself but ive read many ladies you have mc go on to have there immunes tested. Its private and they test for Natural Killer cells and so forth. I dont know too much but they go on some steriods and hormone injections i think. Maybe you can google it. I know a Dr Gorgy in London does the test. Im sure if you do a search on his name you will find some answers.

Dilek

 

[sparkle83]

I was told that the highest cause of recurrent m/c in pcos women is over exposure of the egg to LH, particularly with ovulation much later than cd 14. The recommendation for me was metformin and clomid with a view to better egg quality and earlier ovulation (less exposure)

 

[MrsJD]

Not sure about PCOS but I've had 5 MCs and just found the cause to be uterine natural killer cells, they are running the trial in liverpool. I've been on the steriod for months now and so far so good as I'm now over 12 weeks.

If your tests come back all clear the you should asked to be referred. My tests were all clear and this was the only thing they hadn't tested me for.

Good luck with your results.



XXXX

 

[Dilek]

Not sure about PCOS but I've had 5 MCs and just found the cause to be uterine natural killer cells, they are running the trial in liverpool. I've been on the steriod for months now and so far so good as I'm now over 12 weeks.

If your tests come back all clear the you should asked to be referred. My tests were all clear and this was the only thing they hadn't tested me for.

Good luck with your results.



XXXX

This is what i read tooo

 

[Vici]

It has been proved that ladies with PCOS are more likely to miscarry. The figures show about 1 in 4 pregnancies end in MC but is almost 1 in 2 with PCOS.

Taken from a PCOS website...

" LH (luteinizing hormone) hypersecretion. Some women with PCOS have elevated LH during the follicular phase (first half of the cycle), which prematurely sends a signal to the egg that it is about to be released from its follicle. The egg then prematurely disconnects from its supporting cumulus cells, which causes the egg to pause in its maturation process.

It is thought that this interruption in the normal maturation process may result in abnormal chromosomes in the egg, which would then substantially increase the probability of a miscarriage.

Other Hormones. Of course, other hormonal imbalances besides FSH and LH may be involved.

Women who miscarry appear to have higher levels of testosterone and DHEA than women with continuing pregnancies.

Women who miscarry may tend to have higher prolactin and androgen levels during the follicular phase of their menstrual cycle.

Insulin and insulin resistance. Some women with polycystic ovarian syndrome have insulin resistance, where an excessive amount of insulin is required to control blood sugar levels. High insulin levels stimulates further production of LH and testosterone. Excessive levels of insulin, LH and testosterone are associated with poorer egg quality, thus increasing the risk of miscarriage. Insulin resistance has been linked to recurrent pregnancy loss. "

Metformin has been used in lots of ladies I know who have had MCs

 

[cherry22]

Thanks for all your help and advise ladies! i'll find out 2morrow! if it all comes back clear ill ask to be referred. fingers crossed ill be getting somesort of help now! x