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Infertility and Overactive Immune System...

Prayerful - thanks for asking about me.


I'm still waiting for AF to arrive. Then I have my trial cycle where we will be doing a test to see if my endometrium is satisfactory. I'm going to ask my FS about additional medications that will help to provide a better chance at my embryo implanting as well.

My numbers were still pretty high even with the IVIg, so I'm worried that it on its own will not be enough.

I'll let you know when I have more answers!
 
Just wanted to give an update... I had some limited immunology testing done and got my results back today. My NK levels are high so my suspicions were correct about my overactive immune system. The lab also ran a test to determine which treatment would work best for me. Apparently my samples responded best to the intralipid therapy. So, this cycle I will be switching back to Femara (from Clomid) but continue taking Follistim and Ovidrel. I will now also be adding in Prednisone and a 3-hour intralipid infusion. I finally have hope again that we really will get our miracle baby someday (soon)!
 
Just wanted to give an update... I had some limited immunology testing done and got my results back today. My NK levels are high so my suspicions were correct about my overactive immune system. The lab also ran a test to determine which treatment would work best for me. Apparently my samples responded best to the intralipid therapy. So, this cycle I will be switching back to Femara (from Clomid) but continue taking Follistim and Ovidrel. I will now also be adding in Prednisone and a 3-hour intralipid infusion. I finally have hope again that we really will get our miracle baby someday (soon)!

Prayer - sounds like you have the right combination now. I'm glad you got your NK cells tested! I had a similar test done and mine came back with better suppression with IVIg :wacko: I was hoping for the intralipids as they are cheaper and I don't think they effect you as badly as the IVIg does during the 3-4 hour infusion. When are you going to try again? I'm hoping to do my transfer in about 5 weeks!
 
I know, I was excited I responded better to the intralipids. I am a big cheapskate and apparently my body is too! :haha: I'm trying to do a cycle this month. I am supposed to do the infusion next Thursday but I still have to get the meds and find an infusion center. I've hit road blocks in both areas already though. I used to work in a clinic that does occasional infusions and I'm trying to contact my old supervisor to see if she can get me in but she is out of the office until Monday. Then a few hours ago the pharmacy called and told me they are out of the intralipids and won't get any more until March 30, which is way too late for this cycle. I'm praying that I'll be able to find another pharmacy to get the meds from and that they can be shipped in time!

Have you done an IVIg infusion yet? Or will the one in 5 weeks be the first? It sounds like you are doing IVf, right? Will that be your first IVF cycle? We decided to stick with IUIs for a few cycles hoping that the intralipids will make all the difference.

How did your endometrium test go?
 
I know, I was excited I responded better to the intralipids. I am a big cheapskate and apparently my body is too! :haha: I'm trying to do a cycle this month. I am supposed to do the infusion next Thursday but I still have to get the meds and find an infusion center. I've hit road blocks in both areas already though. I used to work in a clinic that does occasional infusions and I'm trying to contact my old supervisor to see if she can get me in but she is out of the office until Monday. Then a few hours ago the pharmacy called and told me they are out of the intralipids and won't get any more until March 30, which is way too late for this cycle. I'm praying that I'll be able to find another pharmacy to get the meds from and that they can be shipped in time!

Have you done an IVIg infusion yet? Or will the one in 5 weeks be the first? It sounds like you are doing IVf, right? Will that be your first IVF cycle? We decided to stick with IUIs for a few cycles hoping that the intralipids will make all the difference.

How did your endometrium test go?

Love your comment about your body being cheap! LOL! I wish mine were, UGH. Nope.. mine responded better to the IVIg. Oh well, I'm just glad I know now before I transfer any more of my precious embryos!

I'm not exactly sure what the next steps are? I think the biopsies will be late next week, maybe Thursday and Saturday?

Then we wait 2 weeks for the results and then I'll do my infusion and probably a week after that we'll do the transfer? I would assume the transfer will be 4 weeks from my biopsy?

I'll know more after my appt on Monday.

No more IVFs for me! I have 4 frozen embryos and that is all, if we can't make a baby with them, then it's game over.
 
It looks like Thursday will be a big day for both of us then! I hope everything goes smoothly with the biopsies. I will definitely be thinking of you.

I just feel so good about this cycle. It was devastating to learn that I am the likely cause of our infertility but at the same time it is a huge relief to know that we should be able to overcome this problem. With the IVIg and your 4 embryos, I'm sure your chances are even greater too! Praying for both of us!
 
It looks like Thursday will be a big day for both of us then! I hope everything goes smoothly with the biopsies. I will definitely be thinking of you.

I just feel so good about this cycle. It was devastating to learn that I am the likely cause of our infertility but at the same time it is a huge relief to know that we should be able to overcome this problem. With the IVIg and your 4 embryos, I'm sure your chances are even greater too! Praying for both of us!

Thanks! Unfortunately my lining decided to crap out :( so I am on provera to bring on AF and we'll try again next cycle. We'll be using the Vivelle Dot patch this time to administer the estrogen. Hopefully that will work better!

GL on Thursday!
 
Thanks Ali! I managed, with DHs help, to get everything arranged for tomorrow. US tomorrow at 8:15am then, if that goes well, the infusion will be tomorrow at 10am! I'm so excited!

Sorry to hear about your lining. How thick did it measure at? Mine was only 5.3 last cycle. I hope next cycle goes better for you!
 
Well, I was hoping to have better news but wanted to give an update. Everything went well with the infusion. In all it took about 5 hours at the infusion center. About 30 min of paperwork and formalities and 3.5 hours for the infusion itself. Then they made me stay for an hour after the infusion ended to observe for any adverse reactions. There were none! Within a few days though I knew the Intralipids were working because I developed my first cold in a very long time! Also, (TMI) the odor I always developed after sex, which I thought was normal, disappeared! I was so sure this would be our month but unfortunately today is CD1 again for me. I think there were timing issues with the trigger and IUI this time, so I'm still hopeful that this is the right treatment for me. I go for baseline U/S tomorrow. Hoping there are no cysts so I can keep trying!
 

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