I'll tell you, I had little to no symptoms my first two pregnancies. This time around I'm not sure if it's because I'm dealing with twins, or the fact that I was on estrogen and progesterone but I've been beyond miserable - terrible cramping and back pain, crippling fatigue, tender breasts, insane bloating and I go back and forth from being nauseated and vomiting up the wazoo to being famished 1000x a day.
I don't talk much about it because I am so grateful to be pregnant at all after what we've been through that I thank God for every awful symptom I have daily.
I hope it's just the twins wreaking their havoc and not the meds so you don't have to worry about those kinds of things when you have to start!
(No joke though, I'd ask her if you can take the suppositories over the PIO. If you have to take them from 16 weeks on you're going to end up unbelievably sore and knotted up. I'm not kidding when I say the needles are giant, you have to stab, and there's such a small space to administer them into your upper bum....many women taking them for assisted repro cycles end up switching because they have a hard time making it from transfer to just finishing up the first tri - a max of 8ish weeks)