Recurrent Miscarriage Thread

[Mrs Reineke]

Well I'm on CD 3 of my second AF since my last mc, so we can start trying again here this month. I'm terrified to say the least. I'm praying all of my research and what we've found out regarding my tests will all be the answer and we'll be able to hang on to the next BFP we get. Since I have Factor V Heterozygous I've been taking one 81mg baby aspirin once a day, Omega 3's which as help thin the blood, vitamin c and a prescription prenatal with more folic acid in it. I had a bunch of other tests done that all came back normal.

Thyroid, progesterone, AMH, FSH, Estradiol.

But a hematologist gave me blood tests for all the other clotting disorders since I have Factor V and they were all normal but my anticardiolipin antibodies one came back showing slightly abnormal, so she said when I get my next BFP to come in to check those levels right away because they can increase in pregnancy, and if that's the case she will have me start Lovenox. I have been freaking myself out because I cannot set up an appointment for this "just in case" I have to wait until I get my BFP and then they said they'll get me in as soon as possible...but the test results can take around a week to get back and both of my mcs have been pretty early, so I'm terrified it will be too late if that is what I need to save my next baby. I'm praying to God that the baby aspirin and Omega 3's will keep everything ok until I can get in to find out if I will in fact need the Lovenox. I wasn't taking anything with my first 2 mcs, just a prenatal vitamin. It's out of my hands though. I can only do what I can do on my side and if I can't set up that appointment until I get a BFP then I'll have to just live with that I guess. I'm just so scared. I don't want to lose a 3rd pregnancy in a row. I'm questioning everything...should I take progesterone even though my levels are normal on CD 21, will waiting to go get the blood test again after I get a BFP be too late by the time my results come back, will the aspirin and omega 3's do the trick or am I missing something, is it the blood clotting disorders that are causing these or something else? I'm a worry wart naturally, so this TTC thing has me all freaked out.

 

[SweetV]

Everything crossed. Are you on any meds? Will you be seen soon.

I've had sixteen first tri loses and a stillbirth in the last six years. The only one that had a good scan at this gestation (where it was the right size and had a normal hb) was the stillbirth (and now this one). So it feels like a positive step for me.

Congrats!!
I'm in a very similar situation, did you do anything different before this pregnancy? I can't seem to make it past the 6-8 week mark and the only time I did was my stillbirth. I've tired vitamins (prenatal & D) aspirin and progesterone and didn't seem to help.

 

[SweetV]

I had my hysteroscopy consultation yesterday. It looks like I may have to go for another D&C on Friday. I had a scan 2 weeks ago that still showed an 8 week sac (after mmc in Oct). I took the misoprostol last week but other than crazy cramps nothing. I took HPT yesterday night and it came back negative however so I'm kinda wondering if the misoprotol worked? Do you think it's possible to have retained products and still have a negative test? It will be my 6th D&C and I'm really trying to avoid it although I've resigned myself at this point. They wouldn't even book my test until my periods are back to normal. I'm so frustrated!!!

 

[DSemcho]

I'm so sorry you are dealing with that Sweet I hope things get better for you.


Anyone have kidney pain after your bfp? I'm having kidney pain that alternates from my left kidney to my right.

 

[confuzion]

Hope - it won't be long now. I can almost guarantee I will still be trying come January, so you'll have at least 1 buddy here!

Mrs R - hope it all works out for the best . I definitely understand your stress though.

SweetV - wish I had an answer for you. Mighty odd that you have a negative test though. I would think no retained products based on that! But I'm no expert.

So ladies, for the first time on this journey, we've gotten a potential answer. My MTHFR test shows that I'm homozygous for the C677T mutation (which I think is pretty much the worst case scenario with MTHFR?).

Doc prescribed FABB/Folgard. But I don't think I will be taking it. Taking the active form of folate instead since from my reading that is more effective if you have MTHFR.

Anyone else have the same mutation here? Or know what the treatment plan usually is?

 

[Tasha]

Sweet V, I'm so sorry for what you're going through I'm on vit d, multi vit, high dose folate, aspirin, steriods anti malaria and fragmin. The only new thing there this time is the fragmin increased from 40mg a day to 180mg.

Confusion I have the same mutation but only the one gene so it's not the same as you. The 5mg folate is for that x

 

[petitpas]

Sweet V, when I had my retained products I still had minimal hcg - it dropped to around 20, I think but I had a lot of active placenta tissue. If you have a sac in there that won't be producing hcg as far as I know. You'd probably have noticed an 8 week sac coming out, too

Sorry you are going through this! I fell pregnant super super quickly after my retained tissue was finally resolved, though (it took three months to sort out) so that was a bonus.

 

[petitpas]

Confuzion, that's some result!
I don't know too much about MTFHR except that heterozygous it is pretty harmless but homozygous isn't. It can cause problems with folate levels as you are aware of (spina bifida is a risk). As with other thrombophilia the recommendation in pregnancy us baby aspirin and 'to consider' Heparin. Heparin is given if there are other risk factors such as being a smoker, over 35, high bmi or with a family history of clots. I would think that from a recurrent miscarriage point of view you could also ask for Heparin.

 

[Hope39]

Well I'm on CD 3 of my second AF since my last mc, so we can start trying again here this month. I'm terrified to say the least. I'm praying all of my research and what we've found out regarding my tests will all be the answer and we'll be able to hang on to the next BFP we get. Since I have Factor V Heterozygous I've been taking one 81mg baby aspirin once a day, Omega 3's which as help thin the blood, vitamin c and a prescription prenatal with more folic acid in it. I had a bunch of other tests done that all came back normal.

Thyroid, progesterone, AMH, FSH, Estradiol.

But a hematologist gave me blood tests for all the other clotting disorders since I have Factor V and they were all normal but my anticardiolipin antibodies one came back showing slightly abnormal, so she said when I get my next BFP to come in to check those levels right away because they can increase in pregnancy, and if that's the case she will have me start Lovenox. I have been freaking myself out because I cannot set up an appointment for this "just in case" I have to wait until I get my BFP and then they said they'll get me in as soon as possible...but the test results can take around a week to get back and both of my mcs have been pretty early, so I'm terrified it will be too late if that is what I need to save my next baby. I'm praying to God that the baby aspirin and Omega 3's will keep everything ok until I can get in to find out if I will in fact need the Lovenox. I wasn't taking anything with my first 2 mcs, just a prenatal vitamin. It's out of my hands though. I can only do what I can do on my side and if I can't set up that appointment until I get a BFP then I'll have to just live with that I guess. I'm just so scared. I don't want to lose a 3rd pregnancy in a row. I'm questioning everything...should I take progesterone even though my levels are normal on CD 21, will waiting to go get the blood test again after I get a BFP be too late by the time my results come back, will the aspirin and omega 3's do the trick or am I missing something, is it the blood clotting disorders that are causing these or something else? I'm a worry wart naturally, so this TTC thing has me all freaked out.

In my experience not everything was found first time round, I was still discovering problems after my 6th loss

You don't always find the problem straight away

Xx

 

[Squig34]

SweetV, sorry to hear of this limbo.

Confuzion, I hope they've now identified the issue & you get your rainbow soon.

Mrs R, one of my consultants told me that aspirin alone is sufficient until BFP but as it's not enough long term, that's why you would then start the blood thinning injections. So try not to worry. You're doing all you can. Unfortunately no one can promise you won't have another loss, but the odds are still very good that you won't, especially if you're getting treatment now. Good luck.

 

[Mrs Reineke]

Sweet- I think it could definently be possible to have a negative HCG test but still have left over tissue. I'm not a doctor by any means, but if the tissue you have left is not actively producing HCG it would totallly make since as to why it's negative. Hang in there.

confuzion-I have Factor V Leiden Heterozygous, so I know a bit about the blood clotting disorders. I also had a slightly abnormal anticardiolipin antibody test which is also a blood clotting disorder. I know that there are many women with your same issues that have had babies. From what I've read, taking baby aspirin and hepirin or lovenox can help thin the blood to allow successful implantation and pregnancy results. I would speak to a hematologist regarding this, they can help for sure!

Tasha-Is your high dose folate in your prenatal vitamin or do you take it separately from that? If so, what is the reason?

Hope-I'm so sorry you have continued to discover problems throughout your losses. That has got to be incredibly difficult. What have been the conclusions to what they have found?

Squig34-Thank you so much for your positive feed back. Made me smile.

AFM: CD 4 and my AF is dying down. We can try again this cycle. Praying all of done and have changed will give us our rainbow baby when we get pregnant again.

 

[blueblue]

confuzion/hope - I'm also going to be trying soon, think AF is coming back in a couple of weeks.

Tasha - so pleased to hear your good news

I feel like acupuncture is really helping me get over my most recent loss, I feel more centred and relaxed. I still feel upset but feel like it's helping me accept how things are. Fingers crossed it will help.

Aust N Z J Obstet Gynaecol. 1991 Nov;31(4):320-2.
Recurrent miscarriage--outcome after supportive care in early pregnancy.
Liddell HS1, Pattison NS, Zanderigo A.
https://www.ncbi.nlm.nih.gov/pubmed/1799343

I found the above abstract from a study in 1991 about giving women with unexplained recurrent miscarriage emotional support and supervision during future pregnancies. It's a small study (51 women) and a few years old, also the control group is quite small (9 women) but the results are interesting - the success rate was 86% for the study group (38 out of 44 pregnancies, 2 women had 2 successful pregnancies) and 33% for the control group (3 out of 9). It makes me wonder if whether stress can have a big impact on pregnancy outcomes - recurrent loss is so stressful anyway and it's very easy to get very stressed out when you get pregnant again. Three of my losses have been a day or two after positive scans, each time I've been really stressed, then really relieved, then found out later there's been a mmc.

https://www.pregnancyandbaby.com/pregnancy/articles/943223/how-stress-is-linked-to-miscarriage

 

[Hope39]

After my 3rd loss i was diagnosed with hypothyroidism, elevated tpo, and a bicornuate uterus, after 4th loss low vit d, After my 6th loss i was diagnosed with a septum (turns out not bicornuate), high nk cells, ureaplasma and another infection.

Im sure there is something else i got wrong, lol

 

[Mrs Reineke]

That's frustrating Hope39.

 

[2kidsplusttc3]

I am so upset with my doctor right now. I have an history of miscarriages. and have been trying to have a baby for 5 years now. And of course my two live children were only here I believe bc I took progesterone injections during my pregnancy. I have low progesterone that is why I miscarry. but my new doctor won't even allow me to be on progesterone when Iam ttc. :/ think it is time for a new doctor.

 

[Mrs Reineke]

That is SO frustrating 2kidsplusttc3!! I'm so sorry!! What were your levels at out of curiousity?

 

[2kidsplusttc3]

That is SO frustrating 2kidsplusttc3!! I'm so sorry!! What were your levels at out of curiousity?

they were only a 2. :/

normal non pregnant is between 8-10.

16 and over is ideal for pregnancy though it might be slightly lower at first.

My kids are literally miracles thanks to the injections

 

[SweetV]

I finally bit the bullet and had the D&C this afternoon. Great news is they did a hysteroscopy to get it out and broke through my adhesions when they did the tissue removal. They have inserted a balloon and a catheter to be removed in 2 weeks and I'm on antibiotics and estrogen until the appointment. Very sore but glad it's all over and by next AF I may be TTC again.

 

[confuzion]

Thanks ladies for weighing in on it for me! Seems I'm just upping my dose of folate for now, not sure what the doc will say about blood thinners. But my coagulation tests have always been normal so don't think he will think it necessary (also don't think any of my losses were due to clotting issues).

Sweetv - . Definitely upside to the D&C is being able to just move on right away. Wishing you a swift recovery.

 

[confuzion]

Oh I did also want to ask if anyone know anything about a slightly elevated prolactin level? Mine was 30.9 ng/mL, well out of the reference range listed of 4-23, and now I'm a bit worried. But I ovulate like clockwork so I know its not affecting that. But does anyone know if it will have a bad effect on pregnancy?