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In need of advice! thank you

waitingindc

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Hi!
I've been lurking here for almost 9 months. I am 37.5 years old, I am overweight, have always been but muscular. I do not have a PCO's diagnosis but do have insulin resistance and some hair on my face but no acne and no cysts but many small follicles but not in the oval PCO's pattern. I'm not sure why I haven't joined, I guess I've just come to that point where I need support and guidance. I hope I can offer the same. I'm really thorough in my fertility research and read all kinds of studies. I've also had an RE for six months and just got an opinion from one of the leading RE's in the US but I'm still at a loss. Today, I'm finally joining because my best friend sent me her positive pregnancy test photo as a text. She's not insensitive, I just have not let on how incredibly painful this process has been for me. I also was the one who told her about ovulation tests and pre seed and of course 3 months later she is pregnant -my age as well.

We got married when I was 32 in 2008. In November 2011 was the first time I was ready to try but that got delayed until spring of 2012 because one of my parents' fell ill and I could not handle the stress. I was also away from my husband for awhile. In spring when we finally decided to try when the ovulation test would get a smily face my husband could not perform, this happened for two months. I soon realized that if I did not tell him about the smiley face, he had no problem - it was stressful for him. We seriously tried for six months before I went to an RE-maybe we rushed it but I was about to turn 37. I passed the clomid challenge test my FSH was 4 at day 10 or 11. My tubes were clear and my husband's sperm count was normal, not great not abnormal but the swimmers he did have moved almost 99%. However the first month my doctor said I did not ovulate - I always felt that my monitoring appointment was too late. Either way he put me on clomid, I did well on clomid at 100gm for 7 days I got 2-3 follicles for two months and one month I got one follicle so the fourth month my doctored up it to 150 for 7 days but I only took 125 for 6 days because I could not bare the side effects. We did four IUI's all BFN, I feel only three of them were timed right. I skipped injectibles and went straight to IVF, on a relative low dose of menopur and follstim - I got 17 eggs. I overstimmed my estrogen was 8000 before trigger, so instead of Hcg my doctor gave me lupron. 15 were mature, 13 fertilized, 12 normally - 3 made it to blastocyst with very good quality - we transfered two - BFN. I have one in the freezer.

After my failed IVF, I needed an emotional break but kept searching my records. I noticed that when I first went to the RE my AIC was 6.4 and my fasting insulin was 28. I also told my doctor that no matter what I did, I just could not take the weight off. He gave me metmorfin 1500mg a day, I've been on it for 3 months. I know insulin causes implantation issues. I know I've only been at this for a year and many try for years so I know that maybe I'm just over emotional but I'm at a loss.

The super specialist I went to told me my RE should have cancelled the IVF cycle when my estrogen was 8000 because it comprimises the quality of the eggs. He said to try naturally for a month or two and take crinone at day 21. If that didn't work he suggested femera and IUI, then injectibles and IUI. He said to also just transfer the frozen embryo that I have. I'm really not sure what to do to transfer the frozen or try naturally.

I was wondering if anyone had insight on whether insulin resistance has been my problem? What I should do next? If I do transfer the embryo should I do medicated or unmedicated? What were your protocals? The three months since my failed IVF, I know I ovulated on my own the first month, however we have avoided pregnancy the last three months because I needed emotional and physical rest and we also travelled to a developing country and were taking malaria and typhoid meds so best to avoid pregnancy.

So what would you do
Femera and intercourse; Femera and IUI, injectibles and IUI or transfer embryo - and how long would you try each scenario before moving to IVF.

I'm really sad, I feel very alone and I just don't know what the right thing to do is. My husband is supportive but I just don't think he gets it no matter how hard he tries and he tries. I could accept that I can't have children because I am okay with adopting or donor eggs, but I think i would prefer to adopt but this hoping and wishing and trying to figure out the cause of my unexplained infertility is driving me crazy. I read many women's posts after failed IVF's and TTC and I feel that I'm lucky I'm not as sad as they are but I've found the only way I can live my life is to 100% try and put my heart into it or just avoid it and not try like I have for the last 3 months and live my life and travel and have fun etc, concentrate one work and while I do it - I'm happy but with the news of my best friend's pregnancy I know what is lacking in my life. If anyone has advise on the emotional aspects. I'd really appreciate it.

I know this is hard and it takes effort and I'm very grateful to whoever took the time to read this long winded email and for those that have insight who are willing to respond.
 
I forgot to mention my periods have always been regular arriving between 28-31 days.
 
Waiting, given that your questions are very specific about insulin resistance I have no help for you, but I didn't want to read and run. I'm sorry your journey has brought you here but glad you've found us, and I hope someone here can share wisdom with your particular situation. I just started another thread about my ambivalence concerning IVF, so I share your hesitation about what method to try next.

Best of luck to you. :hugs: :hugs: :hugs:
 

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