I reacted really badly to progesterone (Provera) - enormous, painful spots, bloating, hot flushes, nausea, constipation, tiredness and what I now realise was mild depression - along with some of the most vivid nightmares I've ever experienced.
The only thing which seemed to help was taking the pills at night just before bed and making sure I was really well hydrated. I was drinking about 2 litres of water during the day which seemed to ease all my symptoms except the nightmares.
Synthetic hormones are a nightmare, unfortunately a necessary evil for any of us having difficulty TTC!