5th miscarriage

[Trying4first1]

Hey ladies
Anyone else experiencing a big number of losses?
I am having my 5th with no living children.
This time I was on clexane, prednisolone and cyclogest. I have been diagnosed with high NK cells and a borderline clotting disorder.
My bloods have been at a good level so the Clexane did its job. Can only assume it's my immune system attacking the embryo.
The medication didn't get us any further. Again baby has stopped developing around 6 weeks. Every time this happens. We get a heartbeat then they stop growing.
We just don't know what to think. This treatment failing has been a shock as we had so much hope. But then again it was only our first time trying it. Maybe it can take a few attempts? Feeling very fearful the motherhood may never happen. After 3 years of trying and 5 losses it's hard to feel optimistic.
However me and DH have said that we are not giving up.
I am only 31 and feel I have time to fight for what we want, to become parents.
If we ever have a baby this heartbreak will be so worth it 🌈

 

[Sweetkat]

Trying, I am sure you will have a baby very soon.

Have you been tested for everything else? For me they did ovarian reserve, 3D ultrasound of uterus and put fluid in (can't remember what that was called), thyroid antibodies, karyotype for me and OH, sperm and DNA fragmentation (at 3 month intervals), vitamin D and prolactin and then also clotting and NK cells.

If everything comes back normal it could just be bad luck and the treatment will work. I never had definite answers myself which I found hard to deal with.

Fingers crossed

 

[Trying4first1]

Hi Sweetkat
Hope you are doing ok!?
I had a hysteroscopy about 18 months ago which showed a normal cavity but I'm having another under GA in 7 weeks time. This one will be a proper look for scarring and removal of any adhesions as I have had 2x D and Cs.
I have had loads of blood tests. All normal apart from my clotting.
I haven't had any tests for ovarian reserve. What test would this be. Is this the day 3 bloods?
I am looking into the spermcomet test for DNA fragmanetation for hubby as he has never had a sperm test. I feel we need to rule things out incase there is anything.
I suspect my high NK cells are to blame again though.

 

[Sweetkat]

Yes so they take day 3 bloods for AMH, FSH and estradiol and that's an indication of your ovarian reserve. They also count how many follicles you have on day 3 by doing a scan. I wanted to know in case there was an issue as they can prescribe vitamins to improve egg quality.

Are you in the U.K.? There is a guy at Lister who specialises in NK cells - in case he could give you more insight?

I think the comet test is a good idea because if the fragmentition is elevated your OH could take anti-oxidants to improve it and if it's not an issue at least it will be ruled out as an issue.

There are many success stories on here about women with high NK cells having babies after losses, I guess it just takes the right treatment. Hugs xxx

 

[Trying4first1]

Thank you. I think I will have that done. Will be a while though as will be on HRT after my surgery and the coil for 4-6 weeks. So hopefully November or December cycle.
I used to take COQ10 but does t seem to have made difference. But if it was an issue I'm sure there will be something else that can be recommended.
Yeah I'm based in the UK. Where is the Lister based? I've been seen by prof Quenbys team in Coventry for NK cells but they don't do intralipids only the steroids.
Will defiantly do the spermcomet test. Hopefully will do that in September/October after our holiday as I'm assuming it will be costly with a private clinic.
I have read lots of sucess stories which have helped. Most seem to have sucess first time on treatment. But I guess the negative stuff gets posted less often that's all xx

 

[LoriCroit]

I am so sorry you are going through all this, and so many times. Please know you are not alone. We started our marriage with several attempts to conceive, ending in multiple miscarriages, and a premie baby girl, (Erin) who had complications and only lived a week. We were scared and down, we went through testing.

Hang in there, listen to the medical advice you get, try to relax, go through your grieving and look forward.

At the time my husband and I were not "church-goers" but during that time we learned to pray together, we became closer, emotionally and intimately and things started to happen more positively for us. We now have a beautiful son and thank God every day for this blessing.

I wish you well on starting your family. I will be praying for you!

 

[Trying4first1]

Thank you so much Lori

I am so sorry to hear that you have also had huge struggles. Loosing your little girl at a week old must have been absolutely heartbreaking for you both.
I am so glad to hear that you have both come through the other side and have a wonderful son. Such a blessing 🌈

 

[Wobbles]

I'm so sorry to read this and to how determined you are to fight.

I went through struggles, it was the most mentally testing time of my life and we came through.

Do you have a consultant you can talk with about the next step? x

 

[xxmyheartxx]

I'm so sorry trying, sending you many hugs xx

 

[lesondemavie]

Oh trying! Life is just so unfair sometimes. I know someone who went through 10 losses and then finally saw her dreams come true. I think she still doesn't exactly know why. There's so much we don't know. I really hope it doesn't take that much more for you. I think we can learn from her though that no matter your "number" it doesn't mean never. So much love and support your way

 

[Curlymikes]

Hi. I just finished bleeding from my 7th loss. I had 3 m/c then had healthy twins and now just had 4 more m/c since them. Its so hard. They just tested me for clotting disorder and said everything is fine keep trying. I guess i just have to keep hoping.... Maybe the next time will work.

 

[dairymomma]

I'm so sorry you are going thru this again.

I know some women who have had high NK cells have had luck if they've increased their steroid dosage so I don't know if that's an option for you but it could also have been bad luck, unfortunately. I know women who have miscarried with the treatment and yet had successful pgs with the same meds/doses.

And have you tried high dose folate? I have a clotting issue but it's related to an inability to process folic acid so my dr put me on high dose methylfolate and that seems to be the ticket for me.

 

[Trying4first1]

I'm so sorry to read this and to how determined you are to fight.

I went through struggles, it was the most mentally testing time of my life and we came through.

Do you have a consultant you can talk with about the next step? x

Thank you Wobbles x

I emailed my consultant at Coventry and he wants us to try again and said to not let this set back put us off.
I am due for surgery at St. Mary's in September to check for Ashermans. So I will be seeing my consultant there after, I am guessing in October some time. They probably will just say to try again as thats all we can do. Our problems were treated but sadly the meds didn't work. So I am guessing that we are now playing the numbers game?

 

[Trying4first1]

Oh trying! Life is just so unfair sometimes. I know someone who went through 10 losses and then finally saw her dreams come true. I think she still doesn't exactly know why. There's so much we don't know. I really hope it doesn't take that much more for you. I think we can learn from her though that no matter your "number" it doesn't mean never. So much love and support your way

Thanks Les. Hope all is well with you xx
Sucks to be here yet again. Despite all of this I am even more determined to keep on going. The pain is just making me want this even more. I am not giving up. Even if I have to endure this 20 more times I will. I refuse to give up. i will keep going through the heartache until my eggs dry up if thats what it takes. Then I can't say i never tried. I would regret giving up if I did xx

 

[Sweetkat]

I was diagnosed with elevated NK cells myself, but as I had DD without any issues and without medication and as at least two of my losses appear to have been because of chromosomal issues, I was too scared to take steroids. I just googled NK cells again and this came up


https://www.ivf1.com/natural-killer-cells-miscarriage-infertility/

Now I don't know what to believe about NK cells but all I can say is that they are not fully understood and I am proof that even with elevated NK cells normal pregnancy is possible (my DD). I hope they find the treatment that works for you.

 

[Trying4first1]

Hi. I just finished bleeding from my 7th loss. I had 3 m/c then had healthy twins and now just had 4 more m/c since them. Its so hard. They just tested me for clotting disorder and said everything is fine keep trying. I guess i just have to keep hoping.... Maybe the next time will work.

Hi Curlymikes
So sorry that you are also going through recurrent losses.
The fact that you have had healthy twins in between is really positive 😊
I am thinking that this is a nunbers game. Maybe do need to keep trying and hope one day it will work

 

[Alexas Mommy]

Just wanted to express sadness for your losses

 

[Trying4first1]

I'm so sorry you are going thru this again.

I know some women who have had high NK cells have had luck if they've increased their steroid dosage so I don't know if that's an option for you but it could also have been bad luck, unfortunately. I know women who have miscarried with the treatment and yet had successful pgs with the same meds/doses.

And have you tried high dose folate? I have a clotting issue but it's related to an inability to process folic acid so my dr put me on high dose methylfolate and that seems to be the ticket for me.

Hi Dairymomma. Thank you. It's all just so frustrating. Been trying so hard to become a mum with no results yet. But will keep on going x
I emailed my doctor and he just said to try again and didn't say anything about uping the dose at all. I was on 20mg prednisolone this time.
I have a mild clotting disorder treated with clexane. No one has said anything about didferent forms about folic acid. Not even sure it's a thing they suggest here in the UK!?
Was thinking of getting some additional testing done before we try again. Was going to have DH do the spermcomet test for DNA fragmanentaion and I want my egg quality looked at too.
I have surgery in 6 weeks time to check for uterine scars. I am not convinced there will be any but it something to rule out.

 

[Sweetkat]

The NHS just treats everything where there is no obvious cause as unexplained, when clearly after multiple losses things can't just be unexplained. I am based in London and so we had tests and two fertility clinics here (Lister and CRGH) both of which test for everything the NHS doesn't even acknowledge.

I am keeping everything crossed that you have an answer and a treatment that works soon.

 

[dairymomma]

I would ask about the methylfolate as you can have the clotting issue I have (MTHFR) and not have any other signs of it aside from pregnancy loss. For me, I tend to lose my babies between 7-9 weeks and I have bleeds in my first tri even with my successful pregnancies. My hemotologist said the low folate levels I have cause bleeds (which have caused at least one of my losses) and can cause RMC because folate is essential for fetal development. So if I'm chronically low in folate as it is and I don't have enough for the baby to grow properly, it makes sense that I'd lose the pregnancy as my body is sensing something isn't right.

My only successful pregnancies have been when I've taken a high dose methylfolate supplement, progesterone, and daily baby aspirin in the first tri. I continue the methylfolate til delivery and I will take a baby aspirin in the morning if I remember to. (PG brain...)

Also, I know most women on steroids have tried upping their dosage by 5mg the next pg so maybe you could ask about that too?