Recurrent Miscarriage Thread

[Hope39]

Hope- Did Dr Shehata diagnose you with elavated blood nk cells?

Yes hun he did which Is why I got the steroids

I'm not so sure you get steroids out of Quenby unless you have Nk cell biopsy and it's positive . I might be wrong though .

Shehata and Quenby think quite differently sometimes imo and they prescribe different doses at different times in your Cycle too

Shehata was the one that worked for me but Quenby is very good too

Xx

 

[IsaacRalph]

Hope- Did Dr Shehata diagnose you with elavated blood nk cells?

Yes hun he did which Is why I got the steroids

I'm not so sure you get steroids out of Quenby unless you have Nk cell biopsy and it's positive . I might be wrong though .

Shehata and Quenby think quite differently sometimes imo and they prescribe different doses at different times in your Cycle too

Shehata was the one that worked for me but Quenby is very good too

Xx

Was you diagnosed with positive ANA also?

 

[sunny74]

Coooeey, I'm baaaack
Ive been hanging around here far too long, do i win a prize?

Greetings to all you ladies who unfortunately find yourselves here

So the latest mc was Donor eggs from ivf in greece, twins again (hb's at 6w, 7w gone at 8w), hit us harder than any other as we were convinced it was my old crappy eggs..

Back to the drawing board...
Same old problem, ok we need ivf to get pg, but still mc'ing on 20mg steroids, intralipids, prog injections, clexane and aspirin

 

[pinkpassion]

Sunny, I'm sorry!!! I can't even imagine !!!
I'm sorry I'm just jumping in , so forgive me for asking, but have you all had the rpl testing done? What tests did they do? Is that why so many of you are on all those meds?
My dr suspects I have a blood clotting issue, so I will likely be on aspirin and heparin or something similar... depending on what my results are...
Why are some on levonox and some on clexan? What's the difference? Thanks in advance and sorry I'm such a newb!!!

 

[ginny83]

Hi Sunny - so sad to hear about your recent loss

Only 2 things pops into my head... the malaria tablets that Tash had and testing for DQ Alpha match to have lit therapy. Not sure if the idea behind the malaria tablets is the same as intralipids, or if it makes a difference with how our bodies respond to the different treatments - hope that makes sense. I had intralipids and they worked, but don't know if I could have had the malaria tablets instead or if it was because intralipids in particular worked with my body. Also, I don't know much about the DQ alpha stuff, and I do have a feeling that using a donor egg would negate it as I think it's the dna of the embryo and your body's reaction to that.

My FS is also big on taking melatonin to get your body all insync

 

[ginny83]

Hello to everyone else, sorry that you find yourself in here

I don't post as often in here anymore but do try and still keep up. Here's my story for anyone who's interested... My first pregnancy was my DS1 and then I had 4 miscarriages. 3 MMC at 12, 14 and 16 weeks and a chemical. During that journey I thought I had found a FS that could help me as she tested for NK cells , and when I had my last miscarriage (the 14 week one) I was on high dose folate, progesterone, aspirin and clexane (plus all the usual stuff). That FS had tested my NK cells via a blood test and told me I was negative so didn't need steroids. I changed FS after that last miscarriage and the new FS tested for NK cells via biopsy and said I was positive so he put me on a treatment plan of aspirin, steroids, intralipid transfusions, estrogen, progestrone - plus all the supplements that he particularly likes ttc/pregnant women to be taking. This combination worked for me and I was able to bring home my rainbow in Jan

Also I guess it's worth noting that the high NK cells and high ANA levels were the only things I tested positive for... however I also have psoriasis which has been in remission for the past couple of years and essential hypertension which I take meds for. I've been told by everyone that the hypertension shouldn't be the cause of my miscarriages as it's always been controlled (however it did give me probably during late pregnancy when it became out of ontrol). I think there are also links between autoimmune conditions (which psoriasis is) and RM.

 

[sunny74]

Sunny, I'm sorry!!! I can't even imagine !!!
I'm sorry I'm just jumping in , so forgive me for asking, but have you all had the rpl testing done? What tests did they do? Is that why so many of you are on all those meds?
My dr suspects I have a blood clotting issue, so I will likely be on aspirin and heparin or something similar... depending on what my results are...
Why are some on levonox and some on clexan? What's the difference? Thanks in advance and sorry I'm such a newb!!!

Hi pink
Ive had all the tests possible (i think!) ..spent a fortune privately with Dr Gorgy on level 2 immunes.
I think lovenox is the US equivalent to clexane, but i could be wrong, i hope it is as simple as a blood thinner for you pink

Hi Sunny - so sad to hear about your recent loss

Only 2 things pops into my head... the malaria tablets that Tash had and testing for DQ Alpha match to have lit therapy. Not sure if the idea behind the malaria tablets is the same as intralipids, or if it makes a difference with how our bodies respond to the different treatments - hope that makes sense. I had intralipids and they worked, but don't know if I could have had the malaria tablets instead or if it was because intralipids in particular worked with my body. Also, I don't know much about the DQ alpha stuff, and I do have a feeling that using a donor egg would negate it as I think it's the dna of the embryo and your body's reaction to that.

My FS is also big on taking melatonin to get your body all insync

Hi Ginny, bit crap being back here, wonder if i'm the longest serving poster in here that still hasnt got their rainbow...
DrG did suggest LIT and neupogen but ivf consultant didnt think i needed them...she still doesnt think its immunes, she thinks it endometriosis or a sperm problem.
Have a referal in to see shehata again so hopefully he will prescribe hydroxy (malaria tablet) which i see is actually the treatment for lupus...and neupogen hopefully, its expensive privately
I was on melatonin with both ivf's, she said for egg quality, dunno if it works, first time i had 3 blasts 2nd time only one.. who knows

 

[pinkpassion]

Would I know if I had Thyroid issues? I'm thin and healthy, and always had normal Thyroid function, I don't know if that even matters ..

 

[dairymomma]

Pink-I've had all the tests my dr will run for me. Basic clotting disorder panel, lupus, glucose tolerance (or something like that can't remember what it was exactly), STDs, TSH & FSH checked, and progesterone levels monitored. Also tested for rH factor but since DH and I are both + blood types, that not my issue. My story is 10 m/c, 11 angels, and the only partial answer we have/had is my progesterone levels used to be low but normal during my first trimester. With DS and DD, I took progesterone supplements from bfp to 13 weeks (100mg twice a day) and a daily baby aspirin til 36 weeks. With LO, we had upped my progesterone dosage to 200mg twice a day til 14 weeks for my peace of mind as I'd just had a 14 week m/c. Still on the baby aspirin. I see the dr in a few months to have my annual exam and go over my care plan from here on out because I'm getting pg faster and easier, I'm bleeding in the first tri sooner, and we just found out my uncle has 2 genetic clotting disorders that I likely haven't been tested for yet as they are fairly rare. I'm going to ask about heparin or lovenox (they are pretty much the same and as a pp said, heparin and clexane are just different names for the same thing) and steroids being added to my treatment plan. As for thyroid function, yes you can actually have phenomenal numbers and still have a thyroid issue. It depends on what the problem is and what ALL of your numbers are. Most doctors only look at the TSH and if it's in the 'normal' range they don't look any further but the T3 and T4 numbers can actually show things aren't right even if TSH is fine.

 

[IsaacRalph]

Coooeey, I'm baaaack
Ive been hanging around here far too long, do i win a prize?

Greetings to all you ladies who unfortunately find yourselves here

So the latest mc was Donor eggs from ivf in greece, twins again (hb's at 6w, 7w gone at 8w), hit us harder than any other as we were convinced it was my old crappy eggs..

Back to the drawing board...
Same old problem, ok we need ivf to get pg, but still mc'ing on 20mg steroids, intralipids, prog injections, clexane and aspirin

Sorry to hear that you have had to come back here sunny! Fx'd that rainbow is just around he corner. X

 

[ItsAWonder]

Hi ladies. May I join in? I had two losses in 2013, one at 5 weeks and one at 8 weeks. The 8 week loss became very complicated and lasted over 1 month before a d&c and hysteroscopy were done to clear my uterus. My doctor ran a number of tests but everything came back normal.

I was then lucky enough to have a successful full-term pregnancy and I have an amazing 14 month old little girl.

I began ttc again a few months ago and got pregnant on my second try. (It took almost a year the first time around so we were very surprised.) However, again, this pregnancy is not viable and it's twins. We will do one more u/s next Thursday b/c my HCG keeps rising but the yolks are very large at this point so none of us have any hope. I already scheduled my d&c for the 17th which is far enough out to know for sure and it will give my body some time to MC naturally.

Honestly, I can't believe I am here again. I felt, without a doubt, that this pregnancy was healthy. Never before have I felt so sure.

The only test I haven't done is karyotyping but I don't want to. If we find there is a chromosome issue the only path will be IVF and that is not something I can afford.

I'm just feeling down and angry and wish there was a way to prevent this from happening.

 

[IsaacRalph]

Hi ladies. May I join in? I had two losses in 2013, one at 5 weeks and one at 8 weeks. The 8 week loss became very complicated and lasted over 1 month before a d&c and hysteroscopy were done to clear my uterus. My doctor ran a number of tests but everything came back normal.

I was then lucky enough to have a successful full-term pregnancy and I have an amazing 14 month old little girl.

I began ttc again a few months ago and got pregnant on my second try. (It took almost a year the first time around so we were very surprised.) However, again, this pregnancy is not viable and it's twins. We will do one more u/s next Thursday b/c my HCG keeps rising but the yolks are very large at this point so none of us have any hope. I already scheduled my d&c for the 17th which is far enough out to know for sure and it will give my body some time to MC naturally.

Honestly, I can't believe I am here again. I felt, without a doubt, that this pregnancy was healthy. Never before have I felt so sure.

The only test I haven't done is karyotyping but I don't want to. If we find there is a chromosome issue the only path will be IVF and that is not something I can afford.

I'm just feeling down and angry and wish there was a way to prevent this from happening.

So sorry your in limbo land waiting for the final date of your pregancy! I had that too with my loss before last one. Waited for few weeks before they all agreed it was a no go! I just wanted you to know that things can change over time and you may have been tested few years back but now it might have changed! I read the other day that with miscarriage you have a 10% chance of developing antiphospholipid syndrome which is a clotting disorder! Pregnancy can do weird and wacky things to the immune system. Anyway just a thought. Xx

 

[ItsAWonder]

Interesting. Every study I read states that if you have APS it can cause miscarriages but miscarriages do not lead to APS. Can you send a link to the article you are referencing?

So far the blood flow to my lost pregnancies has been normal and the enlarged yolks confirm that it's most likely chromosomal, especially since my husband and I are both 38.

 

[IsaacRalph]

Sorry it's a wonder not sure where I read it but I defo did as it really stood out for me! I guess like any autoimmune disease can develop over time so can APS. Pregnancy/miscarriage or the period after it is often when these autoimmune conditions crop up!

 

[ginny83]

Sunny - big hugs, it's so so hard and I think it stings even more when you get that 'left behind' feeling. You will get there! You're still here because you're still fighting for you dream! And we'll be here cheering you along xx

Pink - I dont know much about thyroid issues, but you not only need your TSH checked but also your thyroid antibodies. I think this is what dairy is referring to

Itsawonder - I would always recommend getting your angles chromosomes tested. It helps so much with working out patterns and giving possible answers to why things are happening. I had 3 out of 4 of my losses tested (didnt get the chemical tested) and they showed all normal chromosomes which is such a huge point that there is something wrong with my body rather than the babies. A one off loss with normal chromosomes might not much that much - could be that they only counted the number of chromosomes rather than the order, or it's another genetic issue. Same with a one off abnormal chromosome loss - could be just really a case of bad luck. But I think once you get a pattern going it shows it can reveal lots.

I also got DH and I tested and we were both normal. I'd always rather be in the know to know what the odds are and what it might mean when passing things on etc. Good luck - never easy decisions all this stuff x

 

[Tasha]

Sunny you know I'm gutted for you. As for being the longest without a rainbow, for the longest time that was me and it sucked! No advice about that because there is no comfort.

I don't think there are any more tests you can have, unless you've not had the hidden stuff where you send off blood from your AF? There was also a lady on here whose Dh was being tested for a cloting disorder I think. Failing both of them I would try donor sperm with donor and throw in the anti malaria too

 

[sunny74]

Sunny you know I'm gutted for you. As for being the longest without a rainbow, for the longest time that was me and it sucked! No advice about that because there is no comfort.

I don't think there are any more tests you can have, unless you've not had the hidden stuff where you send off blood from your AF? There was also a lady on here whose Dh was being tested for a cloting disorder I think. Failing both of them I would try donor sperm with donor and throw in the anti malaria too

yep, had that one, we both had ab's, one of the first tests penny insists on before ivf...
Chris doesnt want to do donor sperm. maybe he'll change his mind, tis a huge decision though.

 

[ginny83]

It is a huge decision. Maybe for him he has to make sure that all other possibilities have been tried first before being able to seriously think about that route?

I shared a link on FB about friends of mine who had a baby using a donor embryo. Even DH had a tear in his eye after it.

 

[ParadiseX3]

Hello ladies, I'm Jessie and I had 3 early miscarriages last year. Jan at 6weeks, May at 5 week, and November at 8 weeks. I went to the hospital and they didn't tell me a reason for any of them. So I am so scared to try again! I want to so bad, like now!! What are some reasons for miscarriage? I heard low progesterone? What are some things I can do to make my body healthier? I would love to have someone to talk with.

 

[blueblue]

Hi Jessie, I'm so sorry for your losses, have you been referred to a Recurrent Miscarriage Clinic for testing? You should be referred after 3 losses. They will test for blood clotting issues, thyroid issues etc. I wasn't sure whether you have been tested and it has come back as unexplained?

Sunny - I'm so sorry it has been going on for so long, I hope you get your rainbow soon