No PCOS, but I do have thyroid issues. I've been on it for about 48 hours now and I am terribly sick, vomiting and super nauseous. She warned of this and intestinal issues. As for trigger and femara, I'm not sure why she chose this route. She has her hands full with me because I had a severe pulmonary embolism from orthotricyclin when I was 19 and we have to be careful with certain meds and hormones because of blood clot risk. I'm calling her on Monday though, I can't take this sick I'm feeling. I wish I could take you gals with me to my appointments so I knew what questions to ask. lol - I feel so in the dark most of the time.