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Spreading out the shots and decreasing the number of injections. As you can see, there are a lot of shots during the first two years of life, often three or four injections at one visit. This can be overwhelming for parents and quite an ordeal for babies. Here are some tips on how you can spread out the shots and decrease the overall number of injections. Ask your doctor about these options:
1. Use a combination Hib/HepB in one injection. There is only one brand that makes this combination. Ask your doctor.
2. There is a Hib vaccine that only requires 3 total shots, instead of 4. The six-month dose is skipped. This is the brand also used in the combination Hib/HepB above.
3. There is one brand of DtaP/Hib that can be combined for the 4th dose at 18 months, but not the earlier doses.
4. During the first two years, most of these shots don't have to be given at the exact above ages. They can be given over a wide range of months. Here are the options for altering the schedule during the first two years:
Spread it out. Each shot should be given at least 6 to 8 weeks apart, except for HepB. (The first two doses can be one month apart  or longer).
HepB. These three shots can be spread out at any time during the first two years. You don't have to start at one month. It can be safely delayed if you wish. The second and third doses must be 4 to 6 months apart.
IPV (polio). These three shots can be given at any time, starting as young as 2 months of age, with the 3rd shot usually between 15 and 24 months.
DtaP. These 4 shots can be given at any time, with the 4th shot usually between 18 and 24 months.
Prevnar. These 4 shots can be given at a variety of times. Additionally, if you wait until your baby is over age one, he will only need one or two shots, instead of four (however, he goes without protection during the first year).
Hib. Can be given at a variety of ages.
MMR and Chickenpox. These can be given any time after the first birthday, and don't have to be given together.
HepA. This does not have to be given at age two. You can delay this one for years.
5. To avoid getting more than two shots at a time, ask your doctor if you can come in for some "shot only" visits in between your regular check ups. This can avoid giving your child as many as four injections at once. One drawback is that you are coming in for a greater number of painful episodes.
6. If the number of shots during these first two years is simply overwhelming to you, the talk with your doctor about spreading them out over several years. The shots that you can safely delay (illnesses that your child has little or no risk of catching as an infant, or are not serious for infants) include Polio, Hep B, and Hep A. A note on Polio: it is not safe to delay this shot if you plan to live in or travel frequently to Africa and some other third world continents. You may also consider delaying the Chickenpox vaccine until your child is done with the rest of the infant immunizations (although delaying this does put your infant at risk of catching the illness). If you give the M-M-R components separately, start with the measles first after age one, then mumps at least one year later, then eventually rubella.
from https://www.askdrsears.com/html/8/T085200.asp