TTC 1st child 35+ (Please spoiler any PG news/announcements).

Will catch up soon... but just saw Pad's post and needed to say....

Pad - I am soooo hoping and praying that Padette is going to be ok :hugs::hugs::hugs:... I am so glad you got this checked out now...:hugs: When you say you now have a goiter - does that mean they found nodules? I have thyroid nodules that I need to get checked every 4-6 months... Is yours visible? Why can't they get this medication right for you?!! :grr::grr: I hope the resident medical experts can help you...:hugs::hugs: Are you still working full-time? or have you reduced to part-time?

Wish we could all gather around you right now to give you a GIANT group-hug:hugs::hugs:
 
Pad - thinking about you and little Padette. Hope the specialist takes care of you. Huge hug :hugs::hugs::hugs:
 
Pad, it's good news that you have been referred to see the specialist. Did the doctor say it would be a quick referral? You can bug the consultants secretary once the referral is done for an early appointment! When you know who you are seeing....you can ring the hospital and ask for dr soandso s sec. Then tell her your story...definitely worth a try!
I am thinking of you and padette and sending you a ton of :hugs: seems like your LO is a tough little bean so far!
 
Sending some hugs to you and padette hon :hugs::hugs::hugs: But yes, little pad seems to be digging in and definitely badger them for all you are worth until you get right in to see someone :thumbup:
 
Big hugs to you Pad. Stay positive. Miracles do happen! :hugs:

Will keep you in our prayers [-o<
 
Double, triple and quadruple everyone's good wishes Pad xxxx

And everyone else, big wave, HI!
 
Hi Pad,
I have my fingers and toes crossed for you and have added a plait in my hair for good measure.

xxj
 
hi pad so pleased you stopped your thyroxine
it may be just that the bhcg in early preg is over stimulating you. it may go down to normal. here is some medical stuff.

Transient hCG-mediated thyrotropin suppression in early pregnancy should not be treated with antithyroid drug therapy. 1/+00
Once the diagnosis of hyperthyroidism is made in a pregnant woman, attention should be focused on determining the etiology of the disorder and whether it warrants treatment. Clinical features that may indicate the presence of significant hyperthyroidism include failure to gain weight, heat intolerance, excessive sweating, and tachycardia, beyond that normally associated with pregnancy.

The two most common types of biochemical hyperthyroidism that occur during pregnancy are gestational hyperthyroidism (e.g., hCG-mediated transient TSH suppression) and GD. Gestational hyperthyroidism is a generally asymptomatic, mild biochemical hyperthyroidism that may be observed in the first trimester of normal pregnancy. It is presumably caused by the high serum hCG of early pregnancy (281) and is not associated with adverse pregnancy outcomes (289). Pregnant women having gestational hyperthyroidism with emesis, and particularly hyperemesis, may develop more profound abnormalities in thyroid function, with biochemically overt hyperthyroidism and clinical symptoms and signs of hyperthyroidism. Complicated cases of gestational hyperthyroidism should be referred to medical centers with specific expertise in treating these patients.

Technical remarks: There is no evidence that treatment of gestational hyperthyroidism with ATDs is beneficial. In these patients, physical examination and repeat thyroid function tests at intervals of 3–4 weeks is recommended. If the differential diagnosis of the type of hyperthyroidism is unclear (i.e., if there is suspicion of GD) or in the case of very symptomatic disease, a trial of ATD therapy may be considered if significant clinical hyperthyroidism is evident.

RECOMMENDATION 70
Antithyroid drug therapy should be used for hyperthyroidism due to GD that requires treatment during pregnancy. Propylthiouracil should be used when antithyroid drug therapy is started during the first trimester. Methimazole should be used when antithyroid drug therapy is started after the first trimester. 1/+00
Untreated or insufficiently treated hyperthyroidism may seriously complicate pregnancy (290–292), and patients with this disorder should be treated at centers with specific expertise in this area. GD as the cause of hyperthyroidism in pregnancy may be diagnosed from typical clinical findings, including the presence of GO and/or serum TRAb in a hyperthyroid patient. Approximately 5% of patients with newly diagnosed Graves' hyperthyroidism are TRAb negative (43,293), especially those with milder disease.

A woman found to have GD before pregnancy and treated with ATD who goes into remission and is euthyroid off medication has a low risk of recurrent hyperthyroidism during pregnancy. However, her risk of relapse (as well as the risk of postpartum thyroiditis) during the postpartum period is relatively high (294). Antithyroid drugs have much the same effect on thyroid function in pregnant as in nonpregnant women. Both ATDs and TRAb pass the placenta and can affect fetal thyroid. On the other hand, T4 and T3 cross the placenta only in limited amounts.

PTU generally has been preferred in pregnancy because of concerns about rare but well-documented teratogenicity associated with MMI, namely, aplasia cutis and choanal or esophageal atresia (81). However, recent concerns about rare but potentially fatal PTU hepatotoxicity have led to a re-examination of the role of PTU in the management of hyperthyroidism in pregnancy (92). The U.S. Food and Drug Administration recently recommended that PTU be reserved for patients who are in their first trimester of pregnancy, or who are allergic to or intolerant of MMI (92,93).

MMI and PTU both appear in breast milk in small concentrations and studies of breast-fed infants of mothers taking ATDs have demonstrated normal thyroid function and subsequent intellectual development (81). However, because of the potential for hepatic necrosis in either mother or child from maternal PTU use, MMI is the preferred ATD in nursing mothers.

RECOMMENDATION 71
We suggest that patients taking methimazole who decide to become pregnant obtain pregnancy testing at the earliest suggestion of pregnancy and be switched to propylthiouracil as soon as possible in the first trimester and changed back to methimazole at the beginning of the second trimester. Similarly, we suggest that patients started on propylthiouracil during the first trimester be switched to methimazole at the beginning of the second trimester. 2/+00
Concern is that changing back and forth between MMI and PTU might lead to poorly controlled thyroid function because of differences in pharmacokinetics and uncertainty about dose equivalency between the two drugs. This situation is complicated by the changing levels of TRAb in pregnancy. In general, a potency ratio of MMI to PTU of at least 20–30:1 is recommended when changing from one drug to another, although there are no studies that have examined this potency ratio directly. For example, 300 mg of PTU would be roughly equivalent to 10 to15mg of MMI (81). Alternatively, rather than switching to MMI at the end of the first trimester, the patient could remain on PTU during the second and third trimesters, and have hepatic enzymes measured every 4 weeks, at the same time that thyroid function is assessed. However, there are no prospective data that show that this type of monitoring is effective in preventing fulminant PTU related hepatotoxicity.

RECOMMENDATION 72
GD during pregnancy should be treated with the lowest possible dose of antithyroid drugs needed to keep the mother's thyroid hormone levels slightly above the normal range for total T4 and T3 values in pregnancy and the TSH suppressed. Free T4 estimates should be kept at or slightly above the upper limit of the nonpregnant reference range. Thyroid function should be assessed monthly, and the antithyroid drug dose adjusted as required. 1/+00
Even if the mother is euthyroid during ATD therapy, there is a risk of inducing fetal hypothyroidism during the second and third trimesters when the fetal thyroid has begun to function (295,296). Thus, the dose of ATD should be kept as low as possible. Block-replacement therapy consisting of ATD plus levothyroxine should not be used in pregnancy. If a woman receiving such therapy becomes pregnant, therapy should be changed to an ATD alone (278).

Technical remarks: Free T4 is the parameter that has been most closely correlated with good fetal outcome. Serum TSH may still be suppressed in these patients and should not be used as the sole guide in treatment, although normalization of maternal TSH during ATD therapy may indicate a need to reduce the dose of ATD (278).
 
How is everyone today??

Pad Hun, I am sending all my pink and positive thoughts your way chickXxxxx

Huge loves to everyone xx
 
Hello ladies,

Pad - Sending well wishes your way!!

Dash - Fingers crossed for you!

Lils - Bet you had a fun weekend!

Owl - This IUI could be the one!

Kismet - :hi:

AngelsMommie - :hi: & big :hugs:

Pebble - :hi:

GrkPrn - big :hugs:

Hello to all the other ladies - Purple, DrH, Nessaw, Moondust, LadyH, Dwrgi, Butterfly, Chicken, Firebaby, La bergere, Maddy, Tiger and anyone that I missed - :hi:

AFM - I have been feeling a little bit under the weather. AF just finished (the 2nd one after surgery. The 1st was fine.) and it lasted for approx. a day and a half!! My ovulation & 2 weeks after that was quite painful so could have been annovulatory & I wondered if that's why. However, I was also freaking out and wondering if scarring removed during surgery had returned. I have been working out alot and lost 6 lbs during the past month. I am seriously considering going to see a psychologist because my mind has been all over the place. Sometimes, I feel just fine and sometimes I freak out and wonder how I will cope and what my life will be like if this does not work out. Mind you - when I was younger, I used to think that I don't have to have kids hence waiting so late. I need perspective. What can the psychologist tell me that you ladies can't though... :). Anyway, have a great day ladies!
 
Sending positive vibes your way Pad. That little one is a tough little lime and will hang tough just like it's mommie. Huge :hug: of comfort. xxxx
 
Oh Pad - I am sending every positive vibe & prayer your way!!!! Can I ask - is that T4 or Free T4? Apparently Free T4 is a better indicator - ? Lil Padette is apparently doing so well via last scan, so maybe its not affecting her as much as its affecting you? But I would get a copy of your tests now & demand immediate treatment or even go to to the Emergency Room at the hospital if you have to. They treat pregnant women very seriously there & perhaps with all of the expertise you can at least get to the right protocol!!! Plus they can test you on the spot with all of that Free T4, Free T3, etc & interpret the results within like an hour or less (vs waiting 3 weeks!). I would do it in a heartbeat. Given what you've been through & how far you've come, I'm not saying you are in immediate danger or anything bc I really have no idea, but I would get this all sorted pronto as it "could" mean saving baby Pad!!! :thumbup:

Sending huge massive :hugs::kiss: & ++~~~~!!! Please keep us updated, hun!
 
Hey Beautiful BNB Babes! Sorry I’ve been MIA – No, I wasn’t eaten by a zombie (I know that’s what you all were thinking) :haha:. Have had Dr appts galore, work has been nuts & have had a few sh**s hit the proverbial fan… lately so only had time for a few journals, but been trying to catch up here & there –

Greenleaf -Welcome to you! I hope your stay is short & sweet :flower:

La Bergere – Welcome to you too! I’m sorry you found yourself here & that :witch: came & got you. Yes, many of us take comfort in the bottom of a glass when she comes – it’s like kryptonite for her, so enjoy those G&T’s. :flower:

Dizzi - :hi: Hope you are successful soon! :flow:

Purps – I only recently caught up on season 2 myself (a week ago) & wowsers! :happydance: It started here on Sunday night, but since I get frustrated watching only 1 episode at a time, I let a few build up & then go serial-watch them on a Sunday :cloud9:. It’s so awesome! Thanks for tips on Looper, my fellow Sci-fi girl! :winkwink:. Guess you’re not popping today… :nope: :hugs:

Dash – I hope you are feeling better? :flower: You are just a regular closet-rocker, aren’t you with all of these concerts! :haha: Hope you can enjoy it & that mucus leaves the building at least for 1 night! Any sign of :witch: (I can’t stalk your chart anymore so…:shrug:). Hope yoru poor foot feels better soon hun! :nope: :flower:

DrH – Yes, the day before O is quite good! As long as EWCM is cooperating, those swimmers can stay around for 2-3 days (up to 5, but that’s sort-of rare circumstances). And Holy Batman 213m :spermy:???!!! :shock::shock::shock: I didn’t even know it could go up that high?! :bodyb: :thumbup:


Angels – you are going to have days like that & you need to honor those feelings bc they are part of you & need to be acknowledged. You are doing way better than a lot of people I know who have lost babies, so I give you so much credit in looking forward & having faith & hope for the future :flower:. You will get your LO, I just know it :flow: :hugs:

Kismet – yes, the great thing about Reiki Circles is that they usually just go off donations, so for like $5 you get an hour of group meditation, lots of energy & some reiki. Found this – seems to be a lot going on in Etobicoke (?) but defo stuff in Toronto & other surrounding areas, too. https://reiki.meetup.com/cities/ca/on/toronto/. You can subscribe ot certain meetups & get email updates. And since you are a Reiki Prac., you can also do terh Reiki shares (which are traditionally Reiki Prac/Masters taking turns on each other – the circles are for all to attend; the public & Prac’s)

Ness – hope you feel better soon, hun :flower:

Owl – Was wondering what happened to you? So sorry for BFN last IUI :nope: yes, I also find :wine: helps – relaxation, spirits go up, etc. Roll-on #4, then!!! :flower:

Pebble – well, I guess I’m glad the process has finally started (that’s kind-of weird to say, though…). But just so you can get some closure, your ectopic fears can be put to rest & move on into a hope-filled future :flower:. Btw, who you calling crazy? I resemble that comment! :haha: (takes one to know one! :winkwink:) Hope your levels are -0- today!

Mirium – Oh honey, this is so very hard. :hugs: Maybe talking to a psychologist will help? If you get a good one, they can do exactly as you said – put things into perspective :thumbup:. Congrats on losing 6lbs, though! :happydance: Can you start TTC this cycle? Also, if it was annov cycle, remember that 1/year is actually normal & then add to that your recent surgery…. I wouldn’t place too much emphasis on that.

Maddy – long time no see! How are you doing? :flower:

Dwrgi - :hugs: & :beer: (cider) for you hun!

:hi: to all of the other lovely ladies here!


AFM – Had an absolute blast at HHN & at Universal. Did lots of screaming between the roller coasters & being chased by escaped convict chicks w/chainsaws, dead people, gargoyles, zombies, vamps, demons, grim reapers & not quite sure what the other ones were exactly? Did some blood shots & walked thru 7 haunted houses. lol Just your avg night at HHN! Got to let off a bunch of steam – I highly recommend it – the best stress reliever out there! Got bitten by fire ants on the last day & swelling in my foot is just now going down (little b******s!). Anyway, just so very busy at work this week (very big case) & with other personal stuff :wacko:. 2nd round of Colonics yesterday – lost another 2 lbs & felt absolutely wonderful after that one :cloud9: – we got all the rest! :happydance:

Anyway – back to work so big luvs to all & especially Pad I am thinking of you hun!!! :hugs:
 
:hi: lovely ladies! :hugs:

Mirium - big hugs for you. I'm sorry to hear that you feel down :hugs: We all understand what you are going through. I feel like I'm in the same boat. I also waited long for TTC because I was never sure if I really wanted kids. And now that it's not working I freak out because I don't know what our life will be like... I apologize for not knowing your story better, but were you seeing an RE and doing fertility treatments? I am asking because it made me feel a lot better after we put a (time) plan in place with my RE all the way up to IVF. At least I know what's going to happen in the upcoming months and I don't fall in a hole every time I get a bfn and think "and now what" :shrug: Seeing a psychologist could be a good idea. They definitely can help you putting things in perspective. Hang in there honey :hugs2: It will all work out :flower:

:hugs: to all!
 
Pad I'm sending you big positive vibes right now and I promise my next shooting star is all yours XXX
 
Miriam, big :hugs:
Sorry you are feeling so down!
It wouldn't hurt at all to find an outlet and talking to someone can only be good for you!

Big loves xxx
 
Hi lovely 35+ers!!!

LaBergere - Hi and enjoy those gin n tonics!!! :thumbup:

Owl - Good luck with the IUI!!! May this one be the charm and lots and lots of :dust: !

Pebble - hope the cramping and bleeding have subsided and you are feeling better. Best wishes and good luck with the HCG test today!! :flower:

Kismet - woo hoooo for the all clear from your Dr to TTC again!! :happydance:

Pad - thinking the pinkest thoughts for you :hugs::hugs:And sending prayers that your appt with the specialist gives you everything you need. Badger them until you get all the answers and help you want!!! So far little padette has been holding on strong so I will keep sending positive pink thoughts your way!! :hugs::kiss:

Dizzi - Hi and welcome!!! :)

Dwrgi - just found your journal!! Hope it's ok if I start stalking. :flower:

Purps - how's your day going? Hope it's wonderful with lots of furbaby cuddling and more yummy food!! :munch:

Mirium - It is so hard to have a racing mind and worrying about everything. A psychologist would be wonderful to let some steam out and find some comfort if you go to one. On a happy note, WOO HOOOO for losing 6 lbs!!! That's AWESOME!!! Way to go and you should be so proud of yourself!! That's a lot of hard work to do that! Huge hugs. :hugs:

Dash - how are you feeling? Hope the snotmonster is gone and that you're feeling better, and that your foot is better!! Lotsof hugs!!! :flower:

Lils - your weekend sounds FAB!!!!! Screaming and drinking and haunted houses sound like an absolute BLAST and huge stress reliever!!! So glad you had so much fun!! And woot for your colonics!!! Will you be doing another session or is that the last one? So sorry about fireants - those bites itch like crazy!!! Just combine bites + itch into a new word and that's what they are!!!! Hope the rest of your work week goes by quickly and that you can have another amazing Florida weekend! :flower:

Hi Nessaw, Angelsmommie, DrHouse, Greeleaf, HappyAuntie, Tigerlily, Butterfly, Maddy, Chicken and all the other wonderful ladies here.:wave:

AFM - I started a journal - it feels good to write stuff down and generally lifts my mood. I did some yoga last night - got a new video. It was HARD but I really like it. It's amazing how yoga helps me find muscles I didn't know I had (or, well, don't have, b/c it's so hard... :haha:) Lots of love and hugs.
 
Hey guys... thanks for all of your thoughts!

I spoke to my Sis's friend who is an endocrinologist nurse and she said that although my levels are high it is more likely affecting me more than baby... I have to say she is prob right cos these heart palps, shakes, sweats and breathlessness is killing me!

I now have an appt on Monday morning with a specialist thank heavens!

Thank you Drh for the info... I think I am in the GD camp...

Someone must of heard you all xxxx

Promise my next post will be less self absorbed!
 

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