Hi Louise,
Yes, Tamoxifen was the first thing the urologist wanted to try with DH, because he said it is non-obstructive, but cannot find any reason for it ... All other spermiogrammes showed either 0 or at most 250k sperm, with little to no motility and very poor morphology (all weird). Instead of doing TESE right away, two years ago he took Tamoxifen for 6 weeks. At the spermiogramme after that, they found 13 MIO sperm, with 8% motility... that was the sample they froze 6 straws of. For all our ICSI tries, they used fresh (found enough to fertilise) and our fertilisation rates were always very good - but no pregnancy! I am just going to list the egg retrievals and those fertilisation rates (since we did have a bunch of cryo-tries as well):
1st : 14 eggs retrieved, 12 mature, 11 fertilised
2nd: 11 eggs retrieved, 10 mature, 7 fertilised
Before this next try, Doctor suggested that DH take Tamoxifen again, so that if we have good results, we could try IMSI. Unfortunately, the drugs seemed to have no impact and his samples was as poor as always...
3rd: 23 eggs retrieved, 18 mature, 15 fertilised (did get 2 6th day blastocysts - everything else barely developed to at most Morula / many cells on 5th day).
4th: 12 eggs retrieved, 10 mature, 5 fertilised - 2 5th day blasts
5th: 13 eggs retrieved, 11 mature, 9 fertilised - 2 5th day blasts
All these always with fresh tries ... only the 3rd, 4th and 5th ICSIs had blasts - the ones before didn't. That was also the stage where we started having the fertilised eggs monitored in an embryoscope (where the environment is apparently even better for them).
Finally - we tried TESE ... and they found nothing that could be used. Since it was on the day of my egg retrieval, they used three straws of the frozen sperm, taken 2 years ago, where we had such great results :
6th: 15 eggs retrieved, 14 mature, 9 fertilised - 1 5th day hatching blastocyst + 1 morula ... and we got our
!
I cannot say much about the Tamoxifen - one time, it worked wonders and I think that is why we are now expecting our miracle. The other time, it had no impact whatsoever.
We have no explanation for the lack of sperm and its quality, I don't know if it was just some freak try two years ago, that has given us our little miracle... but I think it is worth trying it out!