When does implantation take place?
One such relatively recent study tells us that implantation does not always take place on day 7 after ovulation. In fact it very rarely does. This study by AJ Wilcox (1) accurately determined the day of implantation by very sensitive pregnancy test (HCG) measurement compared to ovulation.
HCGhormonestarts being produced when the pregnancy implants into the uterine lining. The findings in normal women trying to conceive included:
first appearance of HCG (implantation) occurred 6-12 days after ovulation
84% of the pregnancies implanted on days 8-10 after ovulation
earlypregnancylossincreased with later implantation -
implantation early pregnancy loss rate13% by day 9
26% on day 10
52% on day 11
86% on day 12 or more
Overall the total pregnancy loss up to 6 weeks was 25%. Now that seems very high to most people but keep in mind many of these pregnancy losses occurred so early that women often were not aware they were even pregnant. The normalearlypregnancyloss rate that most women know about is 15-18% of clinically recognized pregnancies so almost 40% of all pregnancy loss is unrecognized.
When is the best time to have intercourse in order to get pregnant?
Wilcox had also performed previous work in 1995 (2) which demonstrated that pregnancy only occurs if intercourse occurs within the 6 days prior to and including ovulation. Intercourse after the day of ovulation does not result in pregnancy. The probability of conception ranged from 10% when intercourse occurred five days before ovulation to 33% when it occurred on the day of ovulation itself.
This is the data that suggests the best timing of intercourse in order to conceive is day 10, 12, 14 and 16 (in case of late ovulation) of a 28 day cycle or days -4, -2, 0, +2 in relation to expected ovulation in the case of cycles different than 28 days.
When should I begin testing with home urine tests?
Mosthome pregnancyteststhat check urine beta-HCG are sensitive to 20-25 mIU/ml of HCG. The general rule-of thumb is to test at the time when you are a day late for your menses or about 15 days after ovulation. The test can be positive anywhere from about 2-3 days prior to a missed menses to 4-5 days after.
Testing really does depend upon how regular your menses are or in other words how regular ovulation occurs. If you tend to be late (longer than 28 days) with your periods or the timing of menses varies by several days each cycle, then it is better not to waste pregnancy tests by testing at day 28-29 after the last period starts.
Fertilization can be anywhere from 12-24 hours after ovulation.
You also have to look at how your newly fertilized and implanted egg produces HCG. It will double every 2-3 days.
So lets use this as an example.....
(Assume that this person has a normal 28 day cycle...Ovulates Cycle Day 14 and has a 14 day luteal phase.)
Cycle Day 1-Normal Period
Cycle Day 10-BD
Cycle Day 12-BD
Cycle Day 14-BD OVULATION
Cycle Day 15-Fertilization of Egg
Cycle Day 26-Implantation of Egg
Cycle Day 27-HCG of 5
Cycle Day 28-HCG of 8 (EXPECTED PERIOD)
Cycle Day 29--HCG of 15
Cycle Day 30-HCG of 20
Cycle Day 31-HCG of 28
She has purchased a CLEARBLUE EASY HPT which detects HCG at level 25.
So even though the expected period date was on cycle day 28, since it took longer for the fertilized egg to implant...she will not be able to detect her pregnancy until Day 31 of her cycle.
If she had implanted earlier......she would have gotten a positive with the CLEARBLUE EASY HPT on Cycle Day 28, the same as her next expected period.
(example)
Cycle Day 1- Normal Period
Cycle Day 14-BD OVULATION
Cycle Day 23-Implantation
Cycle Day 24-HCG 5
Cycle Day 25- HCG 8
Cycle Day 26-HCG 13
Cycle Day 27-HCG 20
Cycle Day 28-HCG 26 (EXPECTED PERIOD)
Are ovulation prediction tests worth doing?
Pelvic ultrasound looking at the ovaries is considered the gold standard in ovulation prediction in a research setting but obviously in a practical application of a woman trying to conceive, ultrasound is not used. Urinary LH testing has been shown to have a 100% correlation with ultrasound as far as predicting the timing of ovulation (3). In that same study, they looked at cervical mucous changes, basal body temperature (BBT) charts and salivary ferning. Cervical mucous changes only had a correlation of 48%, salivary ferning correlated 37% and BBT has a 30% correlation.
For the home tests that measure LH surge that immediately precedes ovulation, detection of LH occurs at above 30 mIU/ml. This means that women with polycystic ovarian syndrome who have slightly higher resting LH values are still not falsely detected as ovulating. The urinary LH spike occurs about 24-36 hours prior to ovulation so it is very useful for women trying to conceive because it gives them a window of warning. The test will show positive for one or two days and rarely 3 days if you catch a spike right at the beginning and it is a large release of LH.
(https://www.baby-gaga.com/outbound.php?url=https://www.wdxcyber.com/ninfer11.htm&post_id=28081296)
Weeks of pregnancy
Week 3 7DPO HCG 0 to 5
Week 4 14DPO (next period due) HCG 5 to 430
Week 5 21DPO HCG 180 to 7400
Week 6 28DPO HCG 1,100 to 56,500
Weeks 7 to 8 35DPO to 42 DPO HCG 7,600 to 230,000
Weeks 9 to 12 49DPO to 70DPO HCG 25,300 to 290,000
Early Pregnancy Tests20 mIUEarly Pregnancy TestsEarly Pregnancy Tests
AccuHome*25 mIUGermaine Laboratories
4203 Gardendale Center, Suite 230
San Antonio TX 78229
AimStep20 mIUGermaine Laboratories
4203 Gardendale Center, Suite 230
San Antonio TX 78229
Aim Midstream OTC20 mIUGermaine Laboratories
4203 Gardendale Center, Suite 230
San Antonio TX 78229
AimStick PBD20 mIUGermaine Laboratories
4203 Gardendale Center, Suite 230
San Antonio TX 78229
AimStick OTC / AccuDip20 mIUGermaine Laboratories
4203 Gardendale Center, Suite 230
San Antonio TX 78229
Answer Quick & Simple25 mIU1-800-833-9532Church & Dwight
Princeton NJ 08543
Baby Test (Dollar Store)20 mIU1-800-351-0177
Sales Enterprises
12361 Wilkings Ave.
Rockville MD 20852
Clearblue Easy (U.K.)25 mIU0870 5673514
Unipath Ltd., Priory Business Park, Stanard Way
Cardington, Bedford, Bedfordshire MK44 3UP
Clearblue Easy +/-25 mIU1-800-321-EASY
Unipath Diagnostics, Inc.
Priceton, NJ 08542
Clearview25 mIU1-800-899-SELF (7353)
1-617-647-3900
Inverness Medical, Inc.
200 Prospect St., Waltham MA 02154
Confirm 1-Step25 mIU1-770-582-2222
1-334-792-3775Dist. by Durex Consumer Products, Inc.
London International Group, Inc.
3858 Engineering Drive NW
Norcross GA 30092
Crystal Clear (Australia)25 mIU03-9844-4695
Advanced Clinical Systems
PO Box 42, Warradyte Vic 3113
CVS (cartridge)25 mIU1-800-899-SELF (7353)
1-617-647-3900
Inverness Medical, Inc.
200 Prospect St., Waltham MA 02154
CVS (stick test)25 mIU1-800-433-4634,TCPI, Inc., 3333 S.W. 15th Street
Pompano Beach FL 33069
Day Seven (CDN)25 mIU1-800-667-1197
PHMX, Pharmaceutical & Diagnostics Ltd.
Vancouver, BC
dBest One Step20 mIU206-527-5086,
AmeriTek, Inc.
Seattle WA
e.p.t. +/-25 mIU1-800-378-1783
Pfizer Consumer Healthcare
Morris Plains NJ 07950
Equate +/- (Wal*Mart)25 mIU1-877-227-3543LifeCare Medical International Corp.
Philadelphia PA 19044
Equate (Wal*Mart)25 mIU1-877-227-3543LifeCare Medical International Corp.
Philadelphia PA 19044
Fact Plus Select
(blue lines)25 mIU1-800-986-8598
Ross/Abbott Laboratories
Columbus OH 43215
Fact Plus Pro
(blue lines)25 mIU1-800-986-8598
Ross/Abbott Laboratories
Columbus OH 43215
Fastest (U.K.)25 mIUHome Health UK Ltd, Unit 11,
Peerglow Industrial Estate, Olds Approach
Watford, Hertfordshire WD18 9SR
First Response Early Result15-25 or
6.3 mIU
see1-800-367-6022
Church & Dwight
Princeton NJ 08543
First Sign One Step Midstream (U.K.)25 mIUHome Health UK Ltd, Unit 11,
Peerglow Industrial Estate, Olds Approach
Watford, Hertfordshire WD18 9SR
hCG One Step25 mIUACON Laboratories
4108 Sorrento Valley Boulevard
San Diego CA 92121
hCG One Step Ultra10 mIUACON LaboratoriesACON Laboratories
4108 Sorrento Valley Boulevard
San Diego CA 92121
Insta Test hCG25 mIU1-818-591-3194
Cortez Diagnostics, Inc.
23961 Craftsman Road, Suite D
Calabasas CA 91302
Inverness +/-
(various brands)25 mIU1-800-899-SELF (7353)
1-617-647-3900
Inverness Medical, Inc.
200 Prospect St., Waltham MA 02154
Life (CDN)25 mIU1-800-SHOPPERSShopper's Drug Mart
Canada
Lifesign One-Step25 mIU1-877-227-3543LifeCare Medical International Corp.
Philadelphia PA 19044
LifeSign 1 Midstream15 mIU1-888-357-9399
1-858-792-1100
2921 Sandy Pointe No. #3
Del Mar CA 92014
Luna25 mIU1-888-818-5862
1-858-792-1100
PO Box 18028, Vancouver
British Columbia, Canada V6M 4L3
Micro Pregnancy Tests20 mIU
New Choice (Dollar Tree)20 mIU1-800-351-0177Sales Enterprises
12361 Wilkings Ave.
Rockville MD 20852
On Call (U.K.)25 mIUACON LaboratoriesACON Laboratories
4108 Sorrento Valley Boulevard
San Diego CA 92121
One Step Be Sure25 mIU1-800-854-6226
Syntron Bioresearch, Inc.
Carlsbad CA 92008
One Step hCG
Save On Tests20 mIU1-604-684-9372SaveOnTests.com
North Vancouver, BC
V7H 2A5, Canada
Pregnosis (AU)25 mIU1-612-9736-3811
Key Pharmaceuticals
Key Pharmaceuticals Pty Ltd
9-11 Leeds Street
Rhodes, NSW 2138 Australia
Puralin One Step25 mIU1-800-879-2393
Apothecus Pharmaceutical Corp.
Oyster Bay NY 11771
Rapid Self-Test (U.K.)25 mIU01204 362236ARC Pharmacare (2006) Ltd.
PO BOX 2146
Lynstock House, Lynstock Way,
Lostock, Bolton, UK BL6 9AY
Reveal Dipstick (U.K.)25 mIUBR Pharmaceuticals Ltd.
Coal Hill Lane, Farsley,
Leeds LS28 5NA U.K.
Rite-Aid +/-25 mIU1-800-899-SELF (7353)
1-617-647-3900
Inverness Medical, Inc.
200 Prospect St., Waltham MA 02154
Signify hCG20 mIUAbbott Laboratories
200 Abbott Park Road,
Abbott Park IL 60064
Simplicity No Step20 mIUArben Bioscience, LLC
250 Mill Street, Suite 400
Rochester NY 14614
Smart Strip hCG20 mIU
Target +/-25 mIU1-800-899-SELF (7353)
1-617-647-3900
Inverness Medical, Inc.
200 Prospect St., Waltham MA 02154
Tests For Less20 mIU1-479-522-4786
Calhoun Industries, Inc.
9001 Rogers Ave., Suite E
& 10101 Meandering Way
Fort Smith AR 72903
Walgreens +/-25 mIU1-800-899-SELF (7353)
1-617-647-3900
Inverness Medical, Inc.
200 Prospect St., Waltham MA 02154
Web Womb Midstream One-Step10-15 mIU
40-50 mIU
Accu-Clear50 mIUAccu-ClearInverness Medical, Inc.
200 Prospect St., Waltham MA 02154
Boots (U.K.)50 mIU
Clearblue Easy Digital (U.S.)50 mIU1-800-883-EASY (3279)
Unipath
ClearPlan Easy*50 mIU1-800-883-EASY (3279)
Unipath
Dollar General Store50 mIU1-800-899-SELF (7353)
1-617-647-3900
Inverness Medical, Inc.
200 Prospect St., Waltham MA 02154
Drug Emporium One Step50 mIU1-800-899-SELF (7353)
1-617-647-3900
Inverness Medical, Inc.
200 Prospect St., Waltham MA 02154
Early Bird One Step (U.K.)50 mIU01223 638614
Kent Pharmaceuticals Ltd.
Wotton Road, Ashford, Kent TN23 6LL
early Pregnancy test50 mIU1-800-899-SELF (7353)
1-617-647-3900
Inverness Medical, Inc.
200 Prospect St., Waltham MA 02154
Eckerd Digital50 mIU1-800-883-EASY (3279)
Unipath
Eckerd One Step50 mIU1-800-899-SELF (7353)
1-617-647-3900
Eckerd Drug Company
Clearwater FL 33758
e.p.t. 1Step*40 mIU1-800-EPT-1STEP
1-800-378-1783
Pfizer Consumer Healthcare
Morris Plains NJ 07950
e.p.t. Certainty digital50 mIU1-800-378-1783
Pfizer Consumer Healthcare
Morris Plains NJ 07950
Fact Plus Select (pink lines)*40 mIU1-800-986-8598
Ross/Abbott Laboratories
Columbus OH 43215
Fact Plus Pro (pink lines)*40 mIU1-800-986-8598
Ross/Abbott Laboratories
Columbus OH 43215
Family Dollar50 mIU1-800-899-SELF (7353)
1-617-647-3900
Inverness Medical, Inc.
200 Prospect St., Waltham MA 02154
First Response (U.K.)40 mIU01303 221686Feminine Care Research Lab
Carter-Wallace Ltd.
Wear Bay Road, Folkestone
Kent CT19 6PG
Hannaford50 mIU1-800-899-SELF (7353)
1-617-647-3900
Inverness Medical, Inc.
200 Prospect St., Waltham MA 02154
Inverness with | | result (various brands)50 mIU1-800-899-SELF (7353)
1-617-647-3900
Inverness Medical, Inc.
200 Prospect St., Waltham MA 02154
One Step Pregnancy Test50 mIU1-800-899-SELF (7353)
1-617-647-3900
Inverness Medical, Inc.
200 Prospect St., Waltham MA 02154
Predictor (U.K.)50 mIU01480 421817Unit 327, Science Park
Milton Road, Cambridge CB4 4WG
Reveal Midstream (U.K.)50 mIUBR Pharmaceuticals Ltd.
Coal Hill Lane, Farsley,
Leeds LS28 5NA U.K.
Rite-Aid50 mIU1-800-899-SELF (7353)
1-617-647-3900
Inverness Medical, Inc.
200 Prospect St., Waltham MA 02154
Selfcare50 mIU1-800-899-SELF (7353)
1-617-647-3900
Inverness Medical, Inc.
200 Prospect St., Waltham MA 02154
Target50 mIU1-800-899-SELF (7353)
1-617-647-3900
Inverness Medical, Inc.
200 Prospect St., Waltham MA 02154
Walgreens50 mIU1-800-899-SELF (7353)
1-617-647-3900
Inverness Medical, Inc.
200 Prospect St., Waltham MA 02154
Now...for the fun part!!! Determining when you need to test....
HCG Levels during Pregnancy
Days Past Ovulation
Normal HCG Levels:
MIU/ML
7 Days
5-50 (avg. 14)
14 Days
5-50 (avg. 21)
21 Days
5-50 (avg. 42)
28 Days
10-425
35 Days
19-7,340
42 Days
1,080-56,500
7-8 weeks
7,650-229,000
9-12 weeks
25,700-288,000
13-16 weeks
13,300-254,000
17-24 weeks
4,060-165,400
25-40 weeks
3,640-117,000