Kuawen, I just noticed in your signature that you were diagnosed with MTHFR A1298C. I have that as well. What did your dr. say about this? I can't seem to find much info on that particular mutation?
I'm glad to know I'm not the only one
you're actually the third person I've run into on these boards with MTHFR, though the first with the same mutation as me. There's a bit of a story behind my diagnosis, which goes into how I'm treating it:
I was crying to one of my best girl friends one day about all the losses I've had (this is before I was sent to the RE), and she went to her community mommy group for any advice or input on what might be going on with me. Another woman who had had multiple early pregnancy losses (she's been pregnant 21 times and has 6 healthy children, all losses before 6 weeks) came forward and let my friend know that the cause for her losses had been MTHFR. So my friend encouraged me to ask to be tested for it and I had to really strong arm my OBGYN to do it, and tested positive.
Unfortunately the moment the positive results came back my OBGYN informed me that he could not treat it and referred me over to the RE. The RE then told me he wouldn't treat me for it and doesn't believe it is the cause for my losses because they happened so early, and as far as he knows MTHFR only causes losses later in pregnancy
this is of course ridiculous and outdated information.
But you are right; there's not a whole lot out there about MTHFR A1298C. All the attention seems to be on the other gene involved in the mutation. Some studies I've read seem to show that the mutation still causes the inability to absorb folic acid or folate while not causing a rise in homocystine, but others contradict that and say that it does cause a rise in homocystine just as often as the other mutation.
Generally I'm taking the safe approach: I'm taking a supplement of methylfolate (https://www.amazon.com/L-Methylfola...F8&qid=1399411697&sr=8-3&keywords=methyl+life) as well as a subligual B-12 supplement to aid in absorption. As my family DOES have a history of blood clots I'm also taking 81mg of aspirin (baby aspirin) a day, but not everyone with MTHFR A1298C needs baby aspirin. This is the same regiment that doctors should treat their patients regardless of what form of the mutation they have. My hopes is that this will improve my health and energy levels as well as help us keep our next baby. But I am also still undergoing a lot of tests to rule out any other possible causes for the RPL.