Well i got my bloods back a week after methotrexate shot and they were 246. they were 111they before my shot im worried although dr said he wasnt because i thought after the shot they would be dropping . im so afraid my tube will rupture. anyone else experience this. i go back in a week to see what they are.vi am praying they are down.....i dont want another shot i just want this to go away. and my breast have the brightest blue veins it looks like they are bruised. it seems like everyday it increases.