Recurrent Miscarriage Thread

[Hope39]

Hope. I just wanted to add Quenby prescribes steroids from BFP, (that was the case when I seen her) where as Shehata prescribes from Ov.
I had a very early miscarriage (cpg) when I took steroids from BFP, so will be taking from Ov after my appt.
I think a few of us are following this protocol but best done under supervision of a sympathetic consultant.
Good luck xxx.

Lee have you moved from Prof Quenby to Shehata?

 

[Hope39]

Hope, from what I've read on here Prof Quenby is good at replying to emails and phone calls so why don't you ask about the costs? Do you have an NHS referral? If yes, I would expect all the costs of tests to be covered but definitely check.

I'm all on the case today. Apparently, my straining to urinate recently is not normal and I should avoid straining if at all possible! I've strained until my stomach ached! Oh-oh...
They also advised me to go see my GP so that's what I'll be organising tomorrow...

Petitpas i decided to email Prof Quenby.

I asked her whether i had to wait at least 6 weeks for the NK cells tests or if i was to ovulate in the next 4 weeks (for example) could she still do the NK test. I also asked whether there was a cost involved for doing the tests for blood clotting, progesterone and genetics tests and could they be done at the same time as the NK cells test or do i have to wait for 6 weeks at least

She emailed back to say "no additional fee for other tests, i can do as soon as you ovulate"

Woohoo

Does anyone know why its recommended to wait 6 weeks but Prof Quenby is saying i don't have to. it may be that i won't ovulate till 6 weeks has passed anyway but it could be less

 

[LeeC]

Yes hope. Quenby would only prescribe steroids from BFP and that hasnt worked for me, however, she is wonderful and I can only speak highly of her, please bear in mind also I have had at least 10 pg losses. 8 when I seen Quenby so not sure if this had any bearing on her decision, also possibly because mental health was very shaky at this time she didn't want me to take steroids each month as it can heighten these feelings.

I'm going to see Shehata on 8 Nov, tbh I could start following his protocol of everything from Ov but want to make sure I get the correct dose of steroid next time. He will prescribe upto 40mg for very high NK results plus he has been known to use intralipids.
I'm coming to the end of the line now as have tried everything else over the years so its
Worth it.

Mrs Mc. Welcome. Sorry you are joining us here. From experience I would say progesterone from OV. I was on 400 mg of cyclogest and 100mg aspirin. I took unto 800 mg of progesterone in my pg back in January, unfortunately it ended in ectopic, I must add this had nothing to do with taking the progesterone. I was taking this for PRe menstrual syndrome too and it def helped.
Like most of us with unexplained mc, it seems to be aspirin and progesterone, then steroids.
My tests also said no problems!!! Are you kidding me NHS.

Good luck x

 

[petitpas]

Hope, that's great news! I think the 6 weeks is a rule of thumb. If your body recovers enough to ovulate maybe that is recovery enough. Prof Quenby knows what she is doing - she is one of the leading specialists in recurrent miscarriage!

Lee, have you had a hysteroscopy by any chance?

35, the steroids are not given for clotting. They are given for natural killer cell problems and there is even some research (only small scale, though) showing that giving steroids to ladies with antiphospholipid syndrome can give a worse outcome. That is not to say that ladies with antiphospholipid syndrome can't be unlucky and also have nk cell problems, too. Just that steroids as a precaution to everyone with APS isn't the most sensible course of action.

I can't remember who asked about the progesterone (on phone, too lazy to scroll), but I was under the impression that progesterone is needed when there is a problem with the luteal cyst. The deficiency is most apparent early on as embryos either fail to implant (lining not thickened enough by progesterone) or they don't survive long, there is spotting, warnings of imminent af. That's why, for the progesterone to be most effective, it is usually given from just after ovulation.

I could be totally wrong here but I would think that someone who carries to 11 weeks, perhaps even suffers from mmcs (baby dies but body doesn't notice and keeps looking after the baby) does not have a progesterone problem. Possible causes that would come to mind are clotting/APS, nk cells or genetic issues.

This is just from reading stuff on the net - I am by no means a medical expert so could be totally wrong. Maybe someone else can give their opinion on progesterone? Is someone on the PROMISE trial perhaps?

Funnily enough (such a hypocrite that I am) I am on progesterone. I don't think I need it as I am also in a position where my body kills the baby but then keeps looking after it mental psycho style
My consultants don't think the progesterone will harm me or a baby in any way so they are giving it to me in a belt and braces approach.

Ah, just read Lee's bit about progesterone helping with pre menstrual issues... that's a neat aspect I hadn't heard of!

One other thing that is mentioned on here from time to time is vitamin d deficiency.

Apparently a lot of recurrent miscarriers are low in vitamin d. They don't know if it is a contributing factor but I've had consultants in the US and UK advising me to take supplements. You'd need to check the dosage with your doctor, though!

 

[bellamamma]

Mrsmc, I believe that progesterone needs to be from ovulation on, that seems to be what most gals on here are doing now, isn't it everyone? If you've got luteal phase issues, you gotta start the prog in that phase to help. 7 weeks seems strange, why in the world would he wait til then?? I hope the specialist can give you help and hope!

Filipenko - hang in there hun, I know how you feel, we'll get there..

Hugs to all..

 

[bellamamma]

Petitpas, just read smthg yest abt vit d! It said it's needed for the body to produce progesterone, and in places where there is less sunlight, it's good to supplement. I found it on a natural prog cream site (which I use for pms like lee), so it isn't scientifically based data, but interesting nonetheless!

 

[35_Smiling]

Today I'm CD 12 and went in at 9:45am this morning for my scan. there was one 15mm folli. my fs wants me to come back on Saturday for the IUI it will be cd14. I ov 15-16 is this too early?? should I just get it done on Monday (cd16)?

will it mature by then...this is kind of small...isn't it? Arggg so confused...he said my lining is looks great and all...but i wish i should have recorded him so i can go back over the converation...i am still confused... What you ladies think?? Should I change the date and move it to Mnday CD16...

 

[GillAwaiting]

Today I'm CD 12 and went in at 9:45am this morning for my scan. there was one 15mm folli. my fs wants me to come back on Saturday for the IUI it will be cd14. I ov 15-16 is this too early?? should I just get it done on Monday (cd16)?

will it mature by then...this is kind of small...isn't it? Arggg so confused...he said my lining is looks great and all...but i wish i should have recorded him so i can go back over the converation...i am still confused... What you ladies think?? Should I change the date and move it to Mnday CD16...

I just had IUI done last Friday. When I scanned on Thurs morning largest follies were at 16/17 and when they rescanned me the next day they had gone to 24. One day can make huge difference.

Also you are lucky you dont have too many. They had to puncture all the follies on one side for me and drain them. Excruciating pain but it was either that or cancel altogether...

Good luck

 

[35_Smiling]

Today I'm CD 12 and went in at 9:45am this morning for my scan. there was one 15mm folli. my fs wants me to come back on Saturday for the IUI it will be cd14. I ov 15-16 is this too early?? should I just get it done on Monday (cd16)?

will it mature by then...this is kind of small...isn't it? Arggg so confused...he said my lining is looks great and all...but i wish i should have recorded him so i can go back over the converation...i am still confused... What you ladies think?? Should I change the date and move it to Mnday CD16...

I just had IUI done last Friday. When I scanned on Thurs morning largest follies were at 16/17 and when they rescanned me the next day they had gone to 24. One day can make huge difference.

Also you are lucky you dont have too many. They had to puncture all the follies on one side for me and drain them. Excruciating pain but it was either that or cancel altogether...

Good luck

wow so you mean I have hope? Thank God! i was really worried. On the good note its on the right side too so i am happy about that. I am only getting one scan done tho but i hope its all worth it...it would be nice to get bfp on my first round of IUI.

secondly...do we still have ?? i meant to ask the fs

 

[hopeful23456]

Hi Everyone
I have read these forums so many times but have never actually commented, but i thought about time i did join in and maybe get some comfort from others as you all appear to do.
MY husband and i have been trying for our second child now for 5 years and in that 5 yrs have suffered 9 miscarriages, the most recent one only happening 4 weeks ago. The have all ended before 11 weeks, my local hospital have done numerous tests on me and the hubby, and have come up with negative results! I have however been diagnosed with PCO. I have done alot of research over the years as we do when we are looking for answers, and have been asking my consultant for 2 yrs now to try me on progesterone in early pregnancy (I am convincec that this could be my problem) He has eventually agreed to start me on this when pregnant although we now disagree when it should be started i think it needs to be from first positive line, he thinks at 7 weeks, hmmm what do you all think?

Also my Husband and I have now decide to go private down to Prof Lesley Regan in London and see what she can offer us. This is only because we are at the point of, how many more can we take? Will this ever happen for us? I live in Hope.
PHEW!! That was long ladies sorry just wanted to introduce me and my story
CLaire x

welcome to the board! i think everyone who reads these should start posting - it helps alot

after m/c #3, my RE has me take progesterone suppositories (50 mg each) twice/day from 48 hour after IUI until either pos or neg HPT. If neg, stop taking them and AF comes within 2-3 days, if pos, then just keep taking them. hasn't worked yet to keep bfp but hopefully it will soon.

me: 36 mthfr (A1298C hetero)
uterine septum removed Nov, 2010
DH: 34 fine

4 m/c, first in march, 2000, 3 in past 15 months, all unexplained and in weeks 5-6, 1 bfp was with clomid/ovidrel/iui
3 rounds clomid w/ovidrel total

 

[bellamamma]

How are you doing hopeful?? What step of the process are you at now?

 

[GillAwaiting]

Today I'm CD 12 and went in at 9:45am this morning for my scan. there was one 15mm folli. my fs wants me to come back on Saturday for the IUI it will be cd14. I ov 15-16 is this too early?? should I just get it done on Monday (cd16)?

will it mature by then...this is kind of small...isn't it? Arggg so confused...he said my lining is looks great and all...but i wish i should have recorded him so i can go back over the converation...i am still confused... What you ladies think?? Should I change the date and move it to Mnday CD16...

I just had IUI done last Friday. When I scanned on Thurs morning largest follies were at 16/17 and when they rescanned me the next day they had gone to 24. One day can make huge difference.

Also you are lucky you dont have too many. They had to puncture all the follies on one side for me and drain them. Excruciating pain but it was either that or cancel altogether...

Good luck

wow so you mean I have hope? Thank God! i was really worried. On the good note its on the right side too so i am happy about that. I am only getting one scan done tho but i hope its all worth it...it would be nice to get bfp on my first round of IUI.

secondly...do we still have ?? i meant to ask the fs

Yes lots of BDing. They told me verbally and also it was on the advice page thing that they gave me when leaving. I was starting crinone and checked and went back to cyclogest in back passage for 2 day after IUI so that we could BD and give it the best shot. We've got other probs so I dont think it worked but best of luck to you. I didnt think the follies would be big enough either and was quite shocked. Not alone did the lead ones grow but a lot of the others had caught up from being even smaller.

Fingers crossed for you.

 

[Hope39]

Well i have just got back from the doctors as they wanted to discuss my blood tests that they did last week

I have an underactive thyroid and have been prescribed Levothyroxine (25mcg),

My TSH level is 9.27miu/L

Some lovely lady on these forums suggested i had a thryoid test, i would never have thought to ask for one myself

 

[Hollybush75]

Wow Hope that is high! I *think* it might have been me who suggested you get tested but I am not sure! Your name rings a bell. I hope it doesn't take you too long to get stable levels (took me 9 months to get stable) and hope for us both that the next pg works out

 

[35_Smiling]

Today I'm CD 12 and went in at 9:45am this morning for my scan. there was one 15mm folli. my fs wants me to come back on Saturday for the IUI it will be cd14. I ov 15-16 is this too early?? should I just get it done on Monday (cd16)?

will it mature by then...this is kind of small...isn't it? Arggg so confused...he said my lining is looks great and all...but i wish i should have recorded him so i can go back over the converation...i am still confused... What you ladies think?? Should I change the date and move it to Mnday CD16...

I just had IUI done last Friday. When I scanned on Thurs morning largest follies were at 16/17 and when they rescanned me the next day they had gone to 24. One day can make huge difference.

Also you are lucky you dont have too many. They had to puncture all the follies on one side for me and drain them. Excruciating pain but it was either that or cancel altogether...

Good luck

wow so you mean I have hope? Thank God! i was really worried. On the good note its on the right side too so i am happy about that. I am only getting one scan done tho but i hope its all worth it...it would be nice to get bfp on my first round of IUI.

secondly...do we still have ?? i meant to ask the fs

Yes lots of BDing. They told me verbally and also it was on the advice page thing that they gave me when leaving. I was starting crinone and checked and went back to cyclogest in back passage for 2 day after IUI so that we could BD and give it the best shot. We've got other probs so I dont think it worked but best of luck to you. I didnt think the follies would be big enough either and was quite shocked. Not alone did the lead ones grow but a lot of the others had caught up from being even smaller.

Fingers crossed for you.

We going to get in on then and if hubbies not up to it then I am just going to take it...what's it called...marriage rape?? Thanks for the advise. Good luck to you too

 

[filipenko32]

Today I'm CD 12 and went in at 9:45am this morning for my scan. there was one 15mm folli. my fs wants me to come back on Saturday for the IUI it will be cd14. I ov 15-16 is this too early?? should I just get it done on Monday (cd16)?

will it mature by then...this is kind of small...isn't it? Arggg so confused...he said my lining is looks great and all...but i wish i should have recorded him so i can go back over the converation...i am still confused... What you ladies think?? Should I change the date and move it to Mnday CD16...

I just had IUI done last Friday. When I scanned on Thurs morning largest follies were at 16/17 and when they rescanned me the next day they had gone to 24. One day can make huge difference.

Also you are lucky you dont have too many. They had to puncture all the follies on one side for me and drain them. Excruciating pain but it was either that or cancel altogether...

Good luck

wow so you mean I have hope? Thank God! i was really worried. On the good note its on the right side too so i am happy about that. I am only getting one scan done tho but i hope its all worth it...it would be nice to get bfp on my first round of IUI.

secondly...do we still have ?? i meant to ask the fs

Yes lots of BDing. They told me verbally and also it was on the advice page thing that they gave me when leaving. I was starting crinone and checked and went back to cyclogest in back passage for 2 day after IUI so that we could BD and give it the best shot. We've got other probs so I dont think it worked but best of luck to you. I didnt think the follies would be big enough either and was quite shocked. Not alone did the lead ones grow but a lot of the others had caught up from being even smaller.

Fingers crossed for you.

We going to get in on then and if hubbies not up to it then I am just going to take it...what's it called...marriage rape?? Thanks for the advise. Good luck to you too

Oh yeah, I hate it when men say they have headaches!!:ROFL: We would never to that to them...

 

[hopeful23456]

How are you doing hopeful?? What step of the process are you at now?

hi bella! I'm 10 dpiui and poas every day. i will give a better update when i know more, just guesses for now. need to get some more sticks. I started acupuncture last week and LOVE it. hoping it makes my blood circulate more if there is an unknown issue (i just have slightly elevated IgM and my protein S was 63% (the lowest normal range is 60%). So i think i do have sticky blood. I'm also rolling on a hard foam roller every night to get my blood circulating in trigger points as i have fibromyalgia. it's like giving yourself a massage. don't know if they have them over there? not alot is known about fibromyalgia but they think blood just stays in your trigger points and doesn't flow enough so your mucles are sore all the time so i'm glad i'm going to try lovenox next time. here's what the foam roller looks like and there are different ways you can roll on it.

https://www.promedxpress.com/produc...ecode=PGOOPF&gclid=CMWS196D-KsCFcYa6wodAnMCsg


how are you? do you have test results that will be coming back?

35 smiling - RE has me do BD night of trigger (are you doing a trigger shot)? then IUI 36 hours later, then BD day after IUI - i've had 2 iuis now and didn't get to do the BD after iui both times (dh was sick this last time) but we did do it night of trigger.

petipas - i have low vit D3, take 2000 iu/day.

 

[Hope39]

Wow Hope that is high! I *think* it might have been me who suggested you get tested but I am not sure! Your name rings a bell. I hope it doesn't take you too long to get stable levels (took me 9 months to get stable) and hope for us both that the next pg works out

It seems highish now that i have done a bit or reading up on it, apparently it should ideally be 1-2 whilst trying to conceive

This might explain why it took 7 months to get pregnant and i am hoping it is the reason for the miscarriages

I at recurrent miscarriage clinic on 15/12/11 so i'll see what they say about it and i have got to be retested in 6-8 weeks

 

[daviess3]

Hi ladies 35 why are they doing iui when u get pg on clomid? I feel confused I wonder whether I should be asking for that? Hope you other ladies are ok?

I called my local hospital an my appointment won't b until mid jan so I have decided to get nk cell test done an take clomid dec then hysterocopy jan if not pg? The con told me it could just b bad luck 1 mmc bad luck 2 chem pg one of those things! 1 blighted ovum is a freak of nature!! Don't no what to think! Also nk cells is it better to have blood test or endo test? Soz for 20 questions? X

 

[LeeC]

Hi Davies.

Biopsy is best for NK cells but they can do bloodwork too, it's not as reliable but tbh I was given the steroids by Quenby without either purely based on my history of miscarriage and the only viable pg being in my tube.
Are you going to see Shehata too?