My nana had 2 grand-daughters, and then 2 great grand-daughters too, but it didn't seem to fill the void she had. My mother looked after her in her ill health and was probably the closest person she had to a daughter and even that didn't seem enough.

I'd have probably put it down to old age and her health and medication, but looking back I can see her lecturing me about 'daughter is a daughter for life, son is a son until he meets his wife' or something like that!
Neither my dad nor my uncle had a super close relationship to her, but I'm thinking that has more to do with the way she treat them and her inability to appreciate what she did have instead of what she didn't

my grandfather passed away when my dad was in his teens and until then was in the navy and away at sea a lot so I can't comment on if she'd have tried again
Motherofboys, hand on heart I feel I've reached the point of acceptance about not having a daughter. Day to day I'm so busy I don't really dwell on it. I love my sons enormously and couldn't imagine life without them. My third pregnancy was where I really struggled with my emotions but he's perfect and I'm glad he's who he is. We're stretched financially right now with the 3... I'd have to move house and obviously get a bigger car if I had number 4 and I don't know how many years I'd be away from considering all that.
My OH and I have talked about a 4th child before (eldest two aren't biologically his but he's raised them from being very small) but if I'm being painfully honest if I had a 4th child both of us would want it to be a girl. He feels exactly the same as I do.